Results 21 to 30 of about 31,790 (211)

Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis

Cell Reports, 2020
Summary: The resolution phase of acute inflammation is essential for tissue homeostasis, yet the underlying mechanisms remain unclear. We demonstrate that resolution of inflammation involves interactions between CD38 and tristetraprolin (TTP). During the
Yeonsoo Joe, Yingqing Chen, Jeongmin Park, Hyo Jeong Kim, So-Young Rah, Jinhyun Ryu, Gyeong Jae Cho, Hye-Seon Choi, Stefan W. Ryter, Jeong Woo Park, Uh-Hyun Kim, Hun Taeg Chung   +11 more
doaj   +1 more source

Calcium/Calmodulin-Mediated Defense Signaling: What Is Looming on the Horizon for AtSR1/CAMTA3-Mediated Signaling in Plant Immunity

Frontiers in Plant Science, 2022
Calcium (Ca2+) signaling in plant cells is an essential and early event during plant-microbe interactions. The recognition of microbe-derived molecules activates Ca2+ channels or Ca2+ pumps that trigger a transient increase in Ca2+ in the cytoplasm.
Peiguo Yuan, Kiwamu Tanaka, B. W. Poovaiah   +2 more
doaj   +1 more source

Essential requirement for JPT2 in NAADP-evoked Ca2+ signaling [PDF]

, 2021
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca2+ from acidic organelles through the activation of two-pore channels (TPCs) to regulate endolysosomal trafficking events.
Slama|, Brailoiu, Eugen, UNTERWALD, ELLEN, Slama, James T, Unterwald|, Gunaratne, Gihan S., Patel, Sandip, Marchant, Jonathan S., He, Shijun, Walseth, Timothy F.   +9 more
core   +1 more source

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3 [PDF]

, 2008
Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine expansion in ataxin-3 (SCA3, MJD1) protein.
X. Chen, Bezprozvanny, I, Nelson, O, Hammer, R, Tu, H, Nukina, N, O. Nelson, N. Nukina, Chen, X, Tang, TS, T.-S. Tang, Pook, M, H. Tu, R. Hammer, I. Bezprozvanny, M. Pook   +15 more
core   +1 more source

p53 alters intracellular Ca2+ signaling through regulation of TRPM4. [PDF]

, 2022
Altered expression of transient receptor potential channel melastatin 4 (TRPM4) contributes to several diseases, including cardiac conduction disorders, immune diseases, and cancer. Yet the underlying mechanisms of TRPM4 expression changes remain elusive.
Kappel, Sven, Rother, Karen, Hauert, Barbara, Peinelt, Christine, Ross, Daniela, Daniela Ross-Kaschitza, Christine Peinelt, Barbara Hauert, Karen Rother, Sven Kappel   +9 more
core   +2 more sources

Astrocytic Ca2+ signaling mediated by the endoplasmic reticulum in health and disease

Journal of Pharmacological Sciences, 2020
Astrocytes generate robust intracellular Ca2+ signals that are assumed to be key regulators of astrocytic function. Among various Ca2+ mobilization mechanisms, Ca2+ release from the endoplasmic reticulum (ER) via the inositol 1,4,5-trisphosphate receptor
Yohei Okubo
doaj   +1 more source

Double-Stranded RNA Attenuates the Barrier Function of Human Pulmonary Artery Endothelial Cells [PDF]

, 2013
Circulating RNA may result from excessive cell damage or acute viral infection and can interact with vascular endothelial cells. Despite the obvious clinical implications associated with the presence of circulating RNA, its pathological effects on ...
Heinemann, Akos, Zoltán Bálint, Akos Heinemann, György Váró (417636), Végh Attila G., Fazakas Csilla, Olschewski Horst, Csilla Fazakas, Krizbai István A., Horst Olschewski, Heinemann Akos, Konya, Viktoria, Diana Zabini, Chandran Nagaraj, Nagaraj Chandran, Váró, György, Bálint Zoltán, Zoltán Bálint (142590), Zabini, Diana, György Váró, Andrea Olschewski, Csilla Fazakas (218764), Akos Heinemann (142582), Olschewski Andrea, Attila G Végh, Olschewski, Horst, Chandran Nagaraj (142558), Bálint, Zoltán, István A Krizbai, István A. Krizbai (218814), Imola Wilhelm (218768), Andrea Olschewski (142595), Fazakas, Csilla, Viktoria Konya, Diana Zabini (142555), Attila G. Végh (417635), Viktoria Konya (176778), Váró György, Krizbai, István Adorján, Wilhelm Imola, Horst Olschewski (142585), Zabini Diana, Konya Viktoria, Olschewski, Andrea, Végh, Attila Gergely, Imola Wilhelm, Wilhelm, Imola   +46 more
core   +1 more source

Studies on the role of Coronin 1 and the actin cytoskeleton in T cell signaling and survival [PDF]

, 2009
Calcium ions (Ca2+) function as universal second messengers in most if not all eukaryotic cells, including the cells of the immunesystem. Ca2+ signals are required for the proper activation of lymphocytes, such as T-lymphocytes, their proliferation ...
Müller, Philipp
core   +1 more source

Mitochondrial Ca2+ Signaling in Health, Disease and Therapy

, 2021
The divalent cation calcium (Ca2+) is considered one of the main second messengers inside cells and acts as the most prominent signal in a plethora of biological processes.
Alberto Danese, Gianluca Aguiari, Roberta Gafà, Giovanni Lanza, Paolo Pinton, Daniela Ramaccini, Lorenzo Modesti, Carlotta Giorgi, Veronica Angela Maria Vitto   +8 more
core   +1 more source

Phosphoinositides and intracellular calcium signaling: novel insights into phosphoinositides and calcium coupling as negative regulators of cellular signaling

Experimental and Molecular Medicine, 2023
Intracellular calcium (Ca2+) and phosphoinositides (PIPs) are crucial for regulating cellular activities such as metabolism and cell survival. Cells maintain precise intracellular Ca2+ and PIP levels via the actions of a complex system of Ca2+ channels ...
Byung-Chul Oh
doaj   +1 more source