Results 21 to 30 of about 245,889 (266)
Regenerative Calcium Currents in Renal Primary Cilia
Frontiers in Physiology, 2022 Polycystic kidney disease (PKD) is a leading cause of end-stage renal disease. PKD arises from mutations in proteins, one a Ca2+-conducting channel, expressed in the primary cilia of renal epithelial cells.
Steven J. Kleene
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Altered Ca2+ signaling in enamelopathies
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2018 Biomineralization requires the controlled movement of ions across cell barriers to reach the sites of crystal growth. Mineral precipitation occurs in aqueous phases as fluids become supersaturated with specific ionic compositions. In the biological world, biomineralization is dominated by the presence of calcium (Ca2+) in crystal lattices.
Miriam, Eckstein +3 more
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Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6
eLife, 2019 Epithelial homeostasis and regeneration require a pool of quiescent cells. How the quiescent cells are established and maintained is poorly understood. Here, we report that Trpv6, a cation channel responsible for epithelial Ca2+ absorption, functions as ...
Yi Xin +6 more
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Calcium Ions Signaling: Targets for Attack and Utilization by Viruses
Frontiers in Microbiology, 2022 Calcium, as a second intracellular messenger, participate in various physiological and biochemical processes, including cell growth and proliferation, energy metabolism, information transfer, cell death, and immune response.
Yang Qu +5 more
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ASIC1a senses lactate uptake to regulate metabolism in neurons
Redox Biology, 2022 Lactate is a major metabolite largely produced by astrocytes that nourishes neurons. ASIC1a, a Na+ and Ca2+-permeable channel with an extracellular proton sensing domain, is thought to be activated by lactate through chelation of divalent cations ...
Ivana Savic Azoulay +9 more
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Cardiac Ca2+ Signaling and Ca2+ Sensitizers
Circulation Journal, 2008 The role of Ca2+ in cardiac excitation-contraction (E-C) coupling has been established by simultaneous measurements of contractility and Ca2+ transients by means of aequorin in intact myocardium and Ca2+ sensitive fluorescent dyes in single myocytes. The E-C coupling process can be classified into 3 processes: upstream (Ca2+ mobilization), central (Ca2+
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TRP channels and Ca2+ signaling [PDF]
Cell Calcium, 2006 There is a rapidly growing interest in the family of transient receptor potential (TRP) channels because TRP channels are not only important for many sensory systems, but they are crucial components of the function of neurons, epithelial, blood and smooth muscle cells.
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Coordination of Ca2+ signalling by NAADP
Trends in Biochemical Sciences, 2001 Nicotinic acid adenine dinucleotide phosphate (NAADP) mobilizes intracellular Ca2+ stores in several cell types. Ample evidence suggests that NAADP activates intracellular Ca2+ channels distinct from those that are sensitive to inositol trisphosphate and ryanodine/cyclic ADP-ribose. Recent studies in intact cells have demonstrated functional coupling ('
Patel, S, Churchill, G, Galione, A
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Experimental and Molecular Medicine, 2023 Intracellular calcium (Ca2+) and phosphoinositides (PIPs) are crucial for regulating cellular activities such as metabolism and cell survival. Cells maintain precise intracellular Ca2+ and PIP levels via the actions of a complex system of Ca2+ channels ...
Byung-Chul Oh
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陆军军医大学学报Objective Acute graft-versus-host disease (aGVHD) is a common immunological complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study aims to investigate the intervention effects of 6-gingerol on aGVHD and explore
HE Yuxuan, WANG Rui
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