Results 41 to 50 of about 31,790 (211)
Friend and foe: β-cell Ca2+ signaling and the development of diabetes
Molecular Metabolism, 2019 Background: The divalent cation Calcium (Ca2+) regulates a wide range of processes in disparate cell types. Within insulin-producing β-cells, increases in cytosolic Ca2+ directly stimulate insulin vesicle exocytosis, but also initiate multiple signaling ...
Paul V. Sabatini +2 more
doaj +1 more source
Alteration of expression of Ca2+ signaling proteins and adaptation of Ca2+ signaling in SERCA2+/- mouse parotid acini. [PDF]
, 2008 PURPOSE: The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), encoded by ATP2A2, is an essential component for G-protein coupled receptor (GPCR)-dependent Ca2+ signaling.
신동민 +4 more
core +1 more source
eLife, 2015 A central question is how specificity in cellular responses to the eukaryotic second messenger Ca2+ is achieved. Plant guard cells, that form stomatal pores for gas exchange, provide a powerful system for in depth investigation of Ca2+-signaling ...
Benjamin Brandt +10 more
doaj +1 more source
Frontiers in Physiology, 2022 Dysferlin-null A/J myofibers generate abnormal Ca2+ transients that are slightly reduced in amplitude compared to controls. These are further reduced in amplitude by hypoosmotic shock and often appear as Ca2+ waves (Lukyanenko et al., J. Physiol., 2017).
Valeriy Lukyanenko +5 more
doaj +1 more source
Reduced endogenous Ca2+ buffering speeds active zone Ca2+ signaling [PDF]
, 2015 Fast synchronous neurotransmitter release at the presynaptic active zone is triggered by local Ca2+ signals, which are confined in their spatiotemporal extent by endogenous Ca2+ buffers.
Matveev, Victor +11 more
core +1 more source
, 2020 Ca2+ is a ubiquitous second messenger that plays an essential role in physiological processes such as muscle contraction, neuronal secretion, and cell proliferation or differentiation.
Pilar Alvarez-Illera +4 more
core +1 more source
陆军军医大学学报Objective Acute graft-versus-host disease (aGVHD) is a common immunological complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study aims to investigate the intervention effects of 6-gingerol on aGVHD and explore
HE Yuxuan, WANG Rui
doaj +1 more source
Cell Reports, 2018 Summary: Calcium is a key regulator of mitochondrial function under both normal and pathological conditions. The mechanisms linking metabolic activity to mitochondrial Ca2+ signaling remain elusive, however.
Marko Kostic +2 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Regenerative Calcium Currents in Renal Primary Cilia
Frontiers in Physiology, 2022 Polycystic kidney disease (PKD) is a leading cause of end-stage renal disease. PKD arises from mutations in proteins, one a Ca2+-conducting channel, expressed in the primary cilia of renal epithelial cells.
Steven J. Kleene
doaj +1 more source