Results 51 to 60 of about 31,790 (211)

On adaptor proteins shaping Ca2+ signals in activated B lymphocytes [PDF]

, 2008
Neumann K. On adaptor proteins shaping Ca2+ signals in activated B lymphocytes. Bielefeld (Germany): Bielefeld University; 2008.Signale des B-Zell-Antigenrezeptors (BZR) regeln sowohl die Aktivierung pathogenspezifischer B-Lymphozyten als auch die ...
Neumann, Konstantin
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Astrocyte arborization enhances Ca2+ but not cAMP signaling plasticity

, 2021
The plasticity of astrocytes is fundamental for their principal function, maintaining homeostasis of the central nervous system throughout life, and is associated with diverse exposomal challenges.
Zorec, Robert, Anemari Horvat, Nina Vardjan, Božić, Mićo, Horvat, Anemari, Verkhratsky, Alexei; id_orcid, Alexei Verkhratsky, Vardjan, Nina, Verkhratsky, Alexei, Robert Zorec, Mićo Božić, Dolanc, Dorian, Petra Tavčar, Tavčar, Petra, Stenovec, Matjaž, Matjaž Stenovec, Dorian Dolanc, Pirnat, Samo, Samo Pirnat, Tavčar Verdev, Petra   +19 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Hypertrophic cardiomyopathy mutations increase myofilament Ca2+ buffering, alter intracellular Ca2+ handling, and stimulate Ca2+-dependent signaling [PDF]

, 2018
Mutations in thin filament regulatory proteins that cause hypertrophic cardiomyopathy (HCM) increase myofilament Ca2+ sensitivity. Mouse models exhibit increased Ca2+ buffering and arrhythmias, and we hypothesized that these changes are primary effects ...
Suketu Patel, Xing Liu, Yin-Hua Zhang, Hugh Watkins, Barbara Casadei, Charles Redwood, Alexander Sparrow, Paul Robinson   +7 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes. [PDF]

, 2010
Phosphoinositol (PhoIns)-specific phospholipase C enzymes (PLCs) are central to the inositol lipid signaling pathways and contribute to intracellular Ca2+ release and protein kinase C activation. Five distinct classes of PhoIns-specific PLCs are known to
Farquharson, C, Lester, D, Roberts, SJ, Stewart, AJ, Mukherjee, J   +4 more
core   +2 more sources

Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6

eLife, 2019
Epithelial homeostasis and regeneration require a pool of quiescent cells. How the quiescent cells are established and maintained is poorly understood. Here, we report that Trpv6, a cation channel responsible for epithelial Ca2+ absorption, functions as ...
Yi Xin, Allison Malick, Meiqin Hu, Chengdong Liu, Heya Batah, Haoxing Xu, Cunming Duan   +6 more
doaj   +1 more source

Reciprocal Relationship Between Calcium Signaling and Circadian Clocks: Implications for Calcium Homeostasis, Clock Function, and Therapeutics

Frontiers in Molecular Neuroscience, 2021
In animals, circadian clocks impose a daily rhythmicity to many behaviors and physiological processes. At the molecular level, circadian rhythms are driven by intracellular transcriptional/translational feedback loops (TTFL).
Javier Cavieres-Lepe, Javier Cavieres-Lepe, John Ewer   +2 more
doaj   +1 more source

Cell cycle-dependent regulation of structure of endoplasmic reticulum and inositol 1,4,5-trisphosphate-induced Ca2+ release in mouse oocytes and embryos [PDF]

, 2003
The organization of endoplasmic reticulum (ER) was examined in mouse eggs undergoing fertilization and in embryos during the first cell cycle. The ER in meiosis 11 (MII)-arrested mouse eggs is characterized by accumulations (clusters) that are restricted
Carroll, J, Marangos, P, FitzHarris, G
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