Results 31 to 40 of about 60,512,053 (199)
Nature Cardiovascular Research, 2022 Atherosclerosis is the major cause of ischemic heart disease and stroke, the leading causes of mortality worldwide. The central pathological features of atherosclerosis include macrophage infiltration and foam cell formation. However, the detailed mechanisms regulating these two processes remain unclear. Here we show that oxidative stress-activated Ca2+
Pengyu Zong +8 more
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TRPM2 Is Not Required for T-Cell Activation and Differentiation [PDF]
Frontiers in Immunology, 2022 Antigen recognition by the T-cell receptor induces a cytosolic Ca2+signal that is crucial for T-cell function. The Ca2+channel TRPM2 (transient receptor potential cation channel subfamily M member 2) has been shown to facilitate influx of extracellular Ca2+through the plasma membrane of T cells.
Niels C. Lory +17 more
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Regulation of TRPM2 by Extra- and Intracellular Calcium [PDF]
The Journal of General Physiology, 2007 TRPM2 is a calcium-permeable nonselective cation channel that is opened by the binding of ADP-ribose (ADPR) to a C-terminal nudix domain. Channel activity is further regulated by several cytosolic factors, including cyclic ADPR (cADPR), nicotinamide adenine dinucleotide phosphate (NAADP), Ca2+ and calmodulin (CaM), and adenosine monophosphate (AMP). In
Starkus, John +3 more
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Cell Research, 2016 Two recent studies reveal a crucial role for the cation channel TRPM2 in sensing warm temperatures, both in the thermoregulatory center of the brain and in the somatosensory system.
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TRPM2 promotes pancreatic cancer by PKC/MAPK pathway
Cell Death and Disease, 2021 The mechanism of pancreatic cancer (PA) is not fully understanded. In our last report, TRPM2 plays a promising role in pancreatic cancer. However, the mechanism of TRPM2 is still unknown in this dismal disease.
Rui Lin +7 more
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TRPM2 channel-mediated ROS-sensitive Ca2+ signaling mechanisms in immune cells
Frontiers in Immunology, 2015 Transient receptor potential melastatin 2 (TRPM2) proteins form Ca2+-permeable cationic channels that are potently activated by reactive oxygen species (ROS).
Sharifah eSyed Mortadza +4 more
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Structures and gating mechanism of human TRPM2 [PDF]
Science, 2018 Architecture of the human TRPM2 channel Adenosine diphosphate–ribose (ADPR) mediates calcium (Ca 2+ ) release by activating the transient receptor potential melastatin 2 (TRPM2) channel.
Longfei Wang +5 more
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, 2021 Gastric adenocarcinoma (GAC) is a common malignant tumor, accounting for 95% of gastric cancers. However, the effects and regulatory mechanisms of long non-coding RNA TRPM2-AS (TRPM2-AS) in GAC have not been fully explored.
Fang Zhou (43765) +5 more
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Activators of TRPM2: Getting it right [PDF]
Journal of General Physiology, 2015 The conclusions we draw regarding the molecular mechanisms that govern ion channel activation rely on both careful experimental design and meticulous analysis and interpretation of the data. A new study on agonist activation of TRPM2 ion channels exemplifies how a rigorous biophysical approach can provide definitive answers to a previously murky ...
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A novel disease connection for TRPM2 channels [PDF]
Channels, 2014 Alzheimer's Disease (AD) is a progressive neurodegenerative condition responsible for dementia in older adults and for which no effective treatment is available.
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