Results 51 to 60 of about 60,512,053 (199)

TRPM2 - An adjustable thermostat

Cell Calcium
The Transient Receptor Potential Melastatin 2 (TRPM2) channel is a homotetrameric ligand-gated cation channel opened by the binding of cytosolic ADP ribose (ADPR) and Ca2+. In addition, strong temperature dependence of its activity has lately become a center of attention for both physiological and biophysical studies.
Bartók, Ádám, Csanády, László
openaire   +2 more sources

Reply to: Heat detection by the TRPM2 ion channel [PDF]

Nature, 2020
sponsorship: We thank all members of the Laboratories of Ion Channel Research and Experimental Gynecology and Obstetrics for comments and discussion. This work was supported by grants from KU Leuven Research Council (C1-TRPLe to T.V), the Research Foundation-Flanders (FWO G.084515N to J.V.
Mulier, Marie, Vandewauw, Ine, Vriens, Joris, Voets, Thomas   +3 more
openaire   +3 more sources

TRPM2 enhances ischemic excitotoxicity by associating with PKCγ [PDF]

Summary: N-methyl-D-aspartate receptor (NMDAR)-mediated glutamate excitotoxicity significantly contributes to ischemic neuronal death and post-recanalization infarction expansion.
Nicholas Legere, Li, Yunfeng, Yue, Lixia, Barbara Miller, Zhichao Yue, Mori, Yasuo, Yunfeng Li, Feng, Jianlin, Cindy X. Li, Hao, Bing, Lixia Yue, Yue, Zhichao, Miller, Barbara, Jianlin Feng, Bing Hao, Zong, Pengyu, Legere, Nicholas, Pengyu Zong, Yasuo Mori, Li, Cindy X   +19 more
core   +1 more source

2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist [PDF]

, 2017
Transient receptor potential melastatin 2 (TRPM2), is a ligand-gated Ca2+-permeable non selective cation channel. While physiological stimuli, e.g. chemotactic agents, evoke controlled Ca2+ signals via TRPM2, pathophysiological signals, such as reactive ...
Christelle Moreau, Wolters, Valerie, Barry V L Potter, Andreas H Guse, Monika D Rozewitz, Mareike Janus, Marianne Flato, Janus, Mareike, Rozewitz, Monika D., Kirchberger, Tanja, Joanna M Watt, Fliegert, Ralf, Tanja Kirchberger, Moreau, Christelle, Harneit, Angelika, Guse, Andreas H, Watt, Joanna M, Winzer, Riekje, Valerie Wolters, Annette Rosche, Feng Gu, Potter, Barry V. L., Bauche, Andreas, Ralf Fliegert, Andreas Bauche, Riekje Winzer, Rosche, Annette, Wolf Pérez, Adriana-Michelle, Flato, Marianne, Gu, Feng, Adriana-Michelle Wolf Pérez, Angelika Harneit   +31 more
core   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Antisense transcription at the TRPM2 locus as a novel prognostic marker and therapeutic target in prostate cancer

, 2015
Overwhelming evidence indicates that cancer is a genetic disease caused by the accumulation of mutations in oncogenes and tumor suppressor genes. It is also increasingly apparent, however, that cancer depends not only on mutations in these coding genes ...
Orfanelli U, Briganti A, Brambilla P, Freschi M, Chiacchiera F, Bellone M, Martinelli Boneschi F, Grioni M, Doglioni C, Jachetti E, Pasini D, Lavorgna G., MONTORSI , FRANCESCO, CASARI , GIORGIO NEVIO   +13 more
core   +2 more sources

The PKC/NOX/ROS and PYK2/MEK/ERK/PARP signalling pathways drive TRPM2 channel activation induced by non-cytolytic oxidative stress in microglial cells

Redox Report
Objectives The study aimed to investigate the signalling mechanism for TRPM2 channel activation by non-cytolytic oxidative stress in microglia.Methods Microglia from wild-type (WT) and TRPM2-knockout (KO) mice were exposed to 10-30 mM H2O2 for up to 24 ...
Sharifah Alawieyah Syed Mortadza, Nur Zulaikha Mohamad Zahir, Chew Tze Wei, Lin-Hua Jiang   +3 more
doaj   +1 more source

PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub

Cancer Science, EarlyView.
PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley   +1 more source

Peripheral nerve injury-induced mechanical allodynia in WT/TRPM2-KO BM chimeric mice.

, 2013
In the pSNL model of neuropathic pain, the 50% withdrawal threshold to mechanical stimuli was determined in the ipsilateral (A) and contralateral paws (B) of TRPM2BM+/Rec+, TRPM2BM–/Rec+, TRPM2BM+/Rec–, and TRPM2BM+/Rec+ mice. *p < 0.05; **p < 0.01; ***p
Kanako So (439401), Shuji Kaneko (203005), Hisashi Shirakawa (203001), Takayuki Nakagawa (202988), Kayoko Asakura (439402), Kayo Haraguchi (439400), Kouichi Isami (439399), Yasuo Mori (320114)   +7 more
core   +1 more source