Results 71 to 80 of about 60,512,053 (199)

Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients

Journal of Translational Medicine, 2019
Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is hallmarked by a significant reduction in natural killer (NK) cell cytotoxicity, a mechanism tightly regulated by calcium (Ca2+).
Cassandra Balinas, Helene Cabanas, Donald Staines, Sonya Marshall-Gradisnik   +3 more
doaj   +1 more source

Reactive Oxygen Species-Induced TRPM2-Mediated Ca²⁺ Signalling in Endothelial Cells

Antioxidants, 2021
Endothelial cells form the innermost layer of blood vessels with a fundamental role as the physical barrier. While regulation of endothelial cell function by reactive oxygen species (ROS) is critical in physiological processes such as angiogenesis ...
Ran Ding, Ya-Ling Yin, Lin-Hua Jiang
doaj   +1 more source

In with the TRP Channels: Intracellular Functions for TRPM1 and TRPM2 [PDF]

Science Signaling, 2009
Cationic channels of the TRP melastatin family are involved in pigmentation and oxidative stress responses.
Sandip, Patel, Roberto, Docampo
openaire   +2 more sources

Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2'-phosphate. [PDF]

, 2015
Transient receptor potential melastatin 2 (TRPM2), a Ca(2+)-permeable cation channel implicated in postischemic neuronal cell death, leukocyte activation, and insulin secretion, is activated by intracellular ADP ribose (ADPR).
László Csanády, Balázs Tóth, Iordanov, Iordan, Csanády, László, Iordan Iordanov, Tóth, Balázs   +5 more
core   +1 more source

Oxidative stress promotes ventilator-induced lung injury through activating NLRP3 inflammasome and TRPM2 channel

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Ventilator has been widely used for life support, but ventilator-induced lung injury (VILI) is still a major problem. Oxidative stress has been considered as a key contributor for VILI, but the specific mechanism remains unclear.
Xiaona An, Xiaotong Sun, Xiaomei Yang, Dejie Liu, Yonghao Hou, Hongli Chen, Jianbo Wu   +6 more
doaj   +1 more source

The Role of Mitochondrial Homeostasis in the Pathogenesis of Chronic Rhinosinusitis

Immunity, Inflammation and Disease, Volume 14, Issue 11, November 2026.
The vicious cycle between pathogenic factors‐induced inflammation, oxidative stress, and mitochondrial dysfunction in the context of chronic rhinosinusitis. Created in BioRender. Taghizadeh‐Hesary (2026) https://BioRender.com/k5f4t1f. ABSTRACT Background Chronic rhinosinusitis (CRS) is a common clinical condition characterized by persistent ...
Babak Ghalehbaghi, Morteza Fallahpour, Mohammad Nabavi, Maryam Jalessi, Hadi Ghanbari, Nasibeh Khayer, Farzad Taghizadeh‐Hesary   +6 more
wiley   +1 more source

Inactivation of TRPM2 Channels by Extracellular Divalent Copper

PLoS ONE, 2014
Cu2+ is an essential metal ion that plays a critical role in the regulation of a number of ion channels and receptors in addition to acting as a cofactor in a variety of enzymes. Here, we showed that human melastatin transient receptor potential 2 (hTRPM2) channel is sensitive to inhibition by extracellular Cu2+.
Yu, W, Jiang, L-H, Zheng, Y, Hu, X, Luo, J, Yang, W   +5 more
openaire   +5 more sources

Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis

Boletín Médico del Hospital Infantil de México, 2016
Background: Breast cancer is one of the most common malignancies affecting women. Recent investigations have revealed a major role of ion channels in cancer. The transient receptor potential melastatin-2 (TRPM2) is a plasma membrane and lysosomal channel
Adriana Sumoza-Toledo, Mario Iván Espinoza-Gabriel, Dvorak Montiel-Condado   +2 more
doaj   +1 more source

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

The ion channel, TRPM2, contributes to the pathogenesis of radiodermatitis [PDF]

Radiation and Environmental Biophysics, 2018
Radiodermatitis is a painful side effect for cancer patients undergoing radiotherapy. Irradiation of the skin causes inflammation and breakdown of the epidermis and can lead to significant morbidity and mortality in severe cases, as seen in exposure from accidents or weapons such as "dirty bombs" and ultimately leads to tissue fibrosis.
Anne-Laure Perraud, Deviyani M. Rao, Elizabeth A. Kosmacek, Aleksandra Dagunts, Rebecca E. Oberley-Deegan, Fabienne Gally   +5 more
openaire   +2 more sources