Results 91 to 100 of about 60,512,053 (199)

The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley   +1 more source

Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway

Molecular Cancer
Background Abnormal angiogenesis is crucial for gallbladder cancer (GBC) tumor growth and invasion, highlighting the importance of elucidating the mechanisms underlying this process.
Zhiqiang He, Yuhan Zhong, Parbatraj Regmi, Tianrun Lv, Wenjie Ma, Junke Wang, Fei Liu, Siqi Yang, Yanjie Zhong, Rongxing Zhou, Yanwen Jin, Nansheng Cheng, Yujun Shi, Haijie Hu, Fuyu Li   +14 more
doaj   +1 more source

Multi‐omics–driven precision medicine

iMeta, Volume 5, Issue 5, October 2026.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

TRPM2 ION CHANNEL REGULATES CANCER CELL SURVIVAL IN A CALCIUM-DEPENDENT MANNER

, 2018
Since the late 1990s, TRPM2 ion channels have been broadly studied in various cancer types. The positive effect of TRPM2 expression on cancer cell viability has been associated with reduced cancer patient survival.
Almasi, Shekoufeh
core  

Rationally designed peptides relieve ischemic stroke by targeting TRPM2 intramolecular interactions

Pharmacological Research
TRPM2 is a calcium-permeable cation channel that functions as an oxidative stress sensor and plays a key role in various pathologies, particularly ischemic stroke. The activation of hsTRPM2 requires cooperative engagement of its N‑ and C‑terminal domains,
Jing Yao, Qing You, Xingyu Liu, Wenxuan Zhen, Maizi Fang, Yanping Luo, Jianan Wu, Zifan Mai, Peilin Yu, Fan Yang, Wei Yang   +10 more
doaj   +1 more source

The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

eLife, 2016
Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca2+-permeable cation channel essential for immunocyte activation, insulin secretion, and postischemic cell death.
Iordan Iordanov, Csaba Mihályi, Balázs Tóth, László Csanády   +3 more
doaj   +1 more source

Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies

MedComm, Volume 7, Issue 10, October 2026.
Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng, Qi Qin, Fang Wang, Kaiyuan Zhang, Zhihua Li, Junlei Chang, Min Yu, Fuyou Guo   +7 more
wiley   +1 more source

Curcumin inhibits activation of TRPM2 channels in rat hepatocytes

Redox Biology, 2016
Oxidative stress is a hallmark of many liver diseases including viral and drug-induced hepatitis, ischemia-reperfusion injury, and non-alcoholic steatohepatitis. One of the consequences of oxidative stress in the liver is deregulation of Ca2+ homeostasis,
E. Kheradpezhouh, G.J. Barritt, G.Y. Rychkov   +2 more
doaj   +1 more source

Investigation Into the Pathogenesis of Type 2 Cardiorenal Syndrome via the ROS–TRPM2 Signaling Axis

Frontiers in Bioscience-Landmark
Background: Type 2 cardiorenal syndrome (CRS) is a complex disease characterized by the interplay between the heart and kidneys. The pathophysiology of type 2 CRS involves multiple molecular signaling pathways.
Yanxia Li, Fengrong Wang
doaj   +1 more source

Nitration of TRPM2 as a Molecular Switch Induces Autophagy during Brain Pericyte Injury [PDF]

, 2017
Aims: Dysfunction of neurovascular pericytes underlies breakdown of the blood-brain barrier, but the molecular mechanisms are largely unknown. In this study, we evaluated the role of the transient receptor potential melastatin-related 2 (TRPM2) channel ...
Chengkun Wang, Lin-Hua Jiang, Wang, C, Christopher S. Wilcox, Zhan, K, Quan Jiang, Jiang, L-H, Wei Yang, Wu, Y, Kaiyu Zhan, Han, F, Meihua Liao, Wilcox, CS, Nannan Lu, Rongrong Tao, Gao, Y, Luo, J, Jiang, Q, Yang, W, Yinping Gao, Yan Wu, Jianhong Luo, Lu, N, Lu, Y, Feng Han, Tao, R, Yingmei Lu, Liao, M   +27 more
core   +1 more source