Results 81 to 90 of about 60,512,053 (199)
Phytotherapy Research, Volume 40, Issue 11, Page 6535-6552, November 2026.ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley +1 more source
Glia and TRPM2 Channels in Plasticity of Central Nervous System and Alzheimer’s Diseases
Neural Plasticity, 2016 Synaptic plasticity refers to the ability of neurons to strengthen or weaken synaptic efficacy in response to activity and is the basis for learning and memory.
Jing Wang +2 more
doaj +1 more source
Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity
Frontiers in Pharmacology, 2018 As an oxidative stress sensor, transient receptor potential melastatin 2 (TRPM2) channel is involved in many physiological and pathological processes including warmth sensing, ischemia injury, inflammatory diseases and diabetes.
Yuhuan Luo +4 more
doaj +1 more source
Involvement of TRPM2 in Peripheral Nerve Injury-Induced Infiltration of Peripheral Immune Cells into the Spinal Cord in Mouse Neuropathic Pain Model. [PDF]
, 2013 Recent evidence suggests that transient receptor potential melastatin 2 (TRPM2) expressed in immune cells plays an important role in immune and inflammatory responses.
So, Kanako +23 more
core +2 more sources
iScienceSummary: Aberrant Ca 2+ signaling, mediated by multiple ion channels, is increasingly recognized as a central driver of irradiation-induced salivary gland dysfunction; however, the underlying molecular mechanisms remain poorly defined.
Viktor R. Drel +6 more
doaj +1 more source
Dependence of NMDA/GSK-3β Mediated Metaplasticity on TRPM2 Channels at Hippocampal CA3-CA1 Synapses
Molecular Brain, 2011 Transient receptor potential melastatin 2 (TRPM2) is a calcium permeable non-selective cation channel that functions as a sensor of cellular redox status. Highly expressed within the CNS, we have previously demonstrated the functional expression of these
Xie Yu-Feng +6 more
doaj +1 more source
Renin‐Angiotensin Signaling and Vascular Function: Insights into Health and Disease
Acta Physiologica, Volume 242, Issue 11, November 2026.ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Giovanni Bertoldi, Swapnil K. Sonkusare
wiley +1 more source
Cancer Management and Research, 2020 Ning Wang,1,2,* Lei Wang,2,* Xinliang Pan1– 3 1Department of Otorhinolaryngology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, People’s Republic of China; 2Department of Otolaryngology, Qilu ...
Wang N, Wang L, Pan X
doaj
BMC Immunology, 2019 Background Natural Killer (NK) cells are effector lymphocytes of the innate immune system and are subclassed into CD56BrightCD16Dim/− and CD56DimCD16+ NK cells.
Cassandra Balinas +3 more
doaj +1 more source
Advanced Science, Volume 13, Issue 56, 9 October 2026.Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou +10 more
wiley +1 more source