Results 101 to 110 of about 60,512,053 (199)

Extracellular-Added ADP-Ribose Increases Intracellular Free Ca2+ Concentration Through Ca2+ Release From Stores, but Not Through TRPM2-Mediated Ca2+ Entry, in Rat β-Cell Line RIN-5F

Journal of Pharmacological Sciences, 2006
.: Intracellular ADP-ribose is an activator of TRPM2, which is a Ca2+-permeable channel and mediates H2O2-induced cell death, in the TRPM2-expressing rat β-cell line RIN-5F.
Ishii Masakazu, Shimizu Shunichi, Hagiwara Tamio, Wajima Teruaki, Miyazaki Akira, Mori Yasuo, Kiuchi Yuji   +6 more
doaj   +1 more source

Intracellular calcium activates TRPM2 and its alternative spliced isoforms

, 2009
Melastatin-related transient receptor potential channel 2 (TRPM2) is a Ca(2+)-permeable, nonselective cation channel that is involved in oxidative stress-induced cell death and inflammation processes.
Yue, Lixia, Du, Jianyang, Xie, Jia, L. Yue, J. Du, J. Xie   +5 more
core   +1 more source

A critical role of TRPM2 channel in Aβ₄₂‐induced microglial activation and generation of tumor necrosis factor‐α [PDF]

, 2017
Amyloid β (Aβ)‐induced neuroinflammation plays an important part in Alzheimer's disease (AD). Emerging evidence supports a role for the transient receptor potential melastatin‐related 2 (TRPM2) channel in Aβ‐induced neuroinflammation, but how Aβ induces ...
Alawieyah Syed Mortadza, S., Jiang, L.H., Sim, J.A., Neubrand, Veronika E., Jiang, L-H, Sim, JA, Neubrand, VE, Lin-Hua Jiang, Veronika E. Neubrand, Sharifah Alawieyah Syed Mortadza, Mortadza, SAS, Joan A. Sim   +11 more
core   +1 more source

Astroglial CD38 impairs hippocampal synaptic plasticity after global cerebral ischemia

Frontiers in Stroke
Cardiac arrest-induced global cerebral ischemia (GCI) results in profound cognitive impairment in survivors. Our prior work demonstrated persistent disruption of long-term potentiation (LTP) in hippocampal CA1 neurons, correlating with learning and ...
Amelia M. Burch, Ami Haas, James E. Orfila, Erika Tiemeier, Cassidy De Anda Gamboa, Nicholas Chalmers, Nidia Quillinan, Paco S. Herson   +7 more
doaj   +1 more source

TRPM2 cation channels modulate T cell effector functions and contribute to autoimmune CNS inflammation.

PLoS ONE, 2012
TRPM2, a highly Ca(2+)-permeable member of the transient receptor potential melastatin-related (TRPM) family of cation channels, is expressed in cells of the immune system. We demonstrate firstly that TRPM2 cation channels on T cells critically influence
Nico Melzer, Gordon Hicking, Kerstin Göbel, Heinz Wiendl   +3 more
doaj   +1 more source

Transient Receptor Potential Melastatin 2 (TRPM2) Channel Plays a Role in Neonatal Hypoxic-ischemic Brain Injury [PDF]

, 2016
Recent advances in stroke research have identified non-glutamate mechanisms associated with ischemic neuronal death in adults. Among the molecules involved in non-glutamate mechanisms, transient receptor potential melastatin 2 (TRPM2), a calcium ...
Huang, Sammen
core   +1 more source

TRPM2 channels mediate ROS-induced actin remodeling and cell migration of prostate cancer cells

BMC Cancer
Background Actin remodeling plays important roles in pathophysiological processes such as cancer metastasis and angiogenesis. Reactive oxygen species (ROS) are signaling molecules thought to regulate cell migration by remodeling actin cytoskeleton ...
Pengwei Qi, Jingting Zhao, Hongtian Zhang, Xingyu Liu, Qing You, Jianguo Niu, Xiangming Ye, Fangfang Li   +7 more
doaj   +1 more source

Cell surface expression of TRPM2 variants.

, 2013
(A) Western blots were performed on two different membrane fractions of HEK-293 cells transfected with a TRPM2 variant and probed with a commercially available anti-TRPM2 antibody. Mock-transfected cells were used as negative control.
Mathis Winking (297698), Daniel C. Hoffmann (297699), Frank J. P. Kühn (297704), Ralf-Dieter Hilgers (297701), Cornelia Kühn (297700), Andreas Lückhoff (297702)   +5 more
core   +1 more source

Diverging roles of TRPV1 and TRPM2 in warm-temperature detection

eLife
The perception of innocuous temperatures is crucial for thermoregulation. The TRP ion channels TRPV1 and TRPM2 have been implicated in warmth detection, yet their precise roles remain unclear.
Muad Y Abd El Hay, Gretel B Kamm, Alejandro Tlaie Boria, Jan Siemens   +3 more
doaj   +1 more source

Flow cytometry analysis of BM-derived cells in WT/TRPM2-KO BM chimeric mice.

, 2013
Representative histograms of GFP+ cells in WT mice (A; negative control), GFP-transgenic mice (B; positive control), TRPM2BM+/Rec+ mice (C), TRPM2BM–/Rec+ mice (D), TRPM2BM+/Rec– mice (E), and TRPM2BM-/Rec– mice (F).
Kanako So (439401), Shuji Kaneko (203005), Hisashi Shirakawa (203001), Takayuki Nakagawa (202988), Kayoko Asakura (439402), Kayo Haraguchi (439400), Kouichi Isami (439399), Yasuo Mori (320114)   +7 more
core   +1 more source