Results 111 to 120 of about 60,512,053 (199)

TRPM2 Channel-Mediated Signalling Mechanisms for Neuronal Cell Death [PDF]

, 2017
Transient receptor potential melastatin-related 2 (TRPM2) channel is gated by ADP-ribose (ADPR) and potently activated by reactive oxygen species (ROS) through stimulating ADPR-generating mechanisms. Recent studies provide evidence to show a crucial role
Li, Xin
core   +1 more source

TRPM2 and biliary acute pancreatitis [PDF]

The Journal of Physiology, 2020
openaire   +4 more sources

Uncovering the Role of TRPM2 in TNBC

Breast cancer has high mortality in women worldwide and is a complex disease. Specifically, TNBC is an aggressive subtype which lacks a unique therapeutic target.
Maliougina, Maria
core   +2 more sources

Salidroside-Mitigated Inflammatory Injury of Hepatocytes with Non-Alcoholic Fatty Liver Disease via Inhibition TRPM2 Ion Channel Activation

Diabetes, Metabolic Syndrome and Obesity, 2019
Qi Feng, Chen Liu, Wei Gao, Xiao-ling Geng, Ning Dai Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, People’s Republic of ChinaCorrespondence: Ning DaiDepartment of ...
Feng Q, Liu C, Gao W, Geng X, Dai N
doaj  

The TRPM2 channel in temperature detection and thermoregulation [PDF]

Temperature, 2016
Gretel B. Kamm, Jan Siemens
openaire   +3 more sources

TRPM2 channels in mitochondrial dynamics and cancer [PDF]

Oncotarget, 2017
Sivaprasadarao, A, Abuarab, N, Li, F
openaire   +3 more sources

TLR4 induced TRPM2 mediated neuropathic pain

Frontiers in Pharmacology
Ion channels play an important role in mediating pain through signal transduction, regulation, and control of responses, particularly in neuropathic pain. Transient receptor potential channel superfamily plays an important role in cation permeability and cellular signaling.
Venkata Kiran Kumar Mandlem, Ana Rivera, Zaina Khan, Zaina Khan, Sohel H. Quazi, Sohel H. Quazi, Farah Deba   +6 more
openaire   +3 more sources

Microglial Transient Receptor Potential Melastatin 2 Deficiency Accelerates Seizure Development via Increasing AMPAR‐Mediated Neuronal Excitability

MedComm
Epilepsy is one of the most common neurological disorders, characterized by the enhancement of neural excitability from a neurocentric perspective. Emerging evidence indicates that microglia play a pivotal role in the pathogenesis of epilepsy through ...
Yingwei Xu, Luyu Ye, Zhisheng Li, Yi Zhang, Ning Hua, Xiaojun Wang, Wangjialu Lu, Jing Xi, Liying Chen, Cenglin Xu, Jiajia Fang, Jianhong Luo, Linhua Jiang, Feng Han, Zhong Chen, Yi Wang, Wei Yang   +16 more
doaj   +1 more source

TRPM2, calcium and neurodegenerative diseases.

International journal of physiology, pathophysiology and pharmacology
NMDA receptor overactivation triggers intracellular Ca(2+) dysregulation, which has long been thought to be critical for initiating excitotoxic cell death cascades associated with stroke and neurodegenerative disease. The inability of NMDA receptor antagonists to afford neuroprotection in clinical stroke trials has led to a re-evaluation of excitotoxic
Yu-Feng, Xie, John F, Macdonald, Michael F, Jackson   +2 more
openaire   +1 more source

Right Place, Right Function: The Contribution of Subcellular Localization to the Physiological Impact of TRPM2 Channels. [PDF]

Life (Basel)
Hasselsweiller A, Nguyen BC, Soussi M, Gkika D.   +3 more
europepmc   +1 more source