Results 61 to 70 of about 60,512,053 (199)

LncRNA TRPM2-AS promotes endometrial carcinoma progression and angiogenesis via targeting miR-497-5p/SPP1 axis

Cellular & Molecular Biology Letters
Background Anti-angiogenic therapy has become one of the effective treatment methods for tumors. Long noncoding RNAs (lncRNAs) are emerging as important regulators of tumorigenesis and angiogenesis in EC.
Hanbo Ma, Fengyun Weng, Xiaowen Tong, Huaifang Li, Yinan Yao, Jiangjing Yuan   +5 more
doaj   +1 more source

TRPM2-mediated Ca2+ signaling as a potential therapeutic target in cancer treatment: an updated review of its role in survival and proliferation of cancer cells

Cell Communication and Signaling, 2023
The transient receptor potential melastatin subfamily member 2 (TRPM2), a thermo and reactive oxygen species (ROS) sensitive Ca2+-permeable cation channel has a vital role in surviving the cell as well as defending the adaptability of various cell groups
Eunus S. Ali, Brototi Chakrabarty, Sarker Ramproshad, Banani Mondal, Neloy Kundu, Chandan Sarkar, Javad Sharifi-Rad, Daniela Calina, William C. Cho   +8 more
doaj   +1 more source

Role of PARP and TRPM2 in VEGF Inhibitor‐Induced Vascular Dysfunction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Hypertension and vascular toxicity are major unwanted side effects of antiangiogenic drugs, such as vascular endothelial growth factor inhibitors (VEGFis), which are effective anticancer drugs but have unwanted side effects, including vascular
Karla B. Neves, Rheure Alves‐Lopes, Augusto C. Montezano, Rhian M. Touyz   +3 more
doaj   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

TRPM2: a multifunctional ion channel for calcium signalling [PDF]

The Journal of Physiology, 2011
The transient potential receptor melastatin‐2 (TRPM2) channel has emerged as an important Ca2+ signalling mechanism in a variety of cells, contributing to cellular functions that include cytokine production, insulin release, cell motility and cell death. Its ability to respond to reactive oxygen species has made TRPM2 a potential therapeutic target for
Adriana, Sumoza-Toledo, Reinhold, Penner
openaire   +2 more sources

TRPM2 exacerbates central nervous system inflammation in experimental autoimmune encephalomyelitis by increasing production of CXCL2 chemokines [PDF]

, 2018
多発性硬化症の新たな病態増悪機構を解明 --TRPM2を介したケモカイン産生が神経炎症の増悪に至る好中球の浸潤を引き起こす--. 京都大学プレスリリース. 2018-09-13.Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS) characterized by demyelination and axonal injury.
Nakagawa, Takayuki, Tsutsui, Masato, Miyamura, Sakie, Kaneko, Shuji, Nagayasu, Kazuki, Hirase, Ryo, Shirakawa, Hisashi, Mori, Yasuo, Shuji Kaneko, Kazuki Nagayasu, Takayuki Nakagawa, Hisashi Shirakawa, Sakie Miyamura, Ryo Hirase, Yasuo Mori, Masato Tsutsui   +15 more
core   +1 more source

A Critical Role of TRPM2 in Neuronal Cell Death by Hydrogen Peroxide

Journal of Pharmacological Sciences, 2006
.: A brief exposure to hydrogen peroxide (H2O2) induces severe deterioration of primary cultured neurons in vitro. We have investigated a link between the H2O2-induced neuronal death and Ca2+-permeable TRPM2 channels regulated by ADP-ribose (ADPR).
Kaneko Shuji, Kawakami Seiko, Hara Yuji, Wakamori Minoru, Itoh Etsuko, Minami Toshiyuki, Takada Yuki, Kume Toshiaki, Katsuki Hiroshi, Mori Yasuo, Akaike Akinori   +10 more
doaj   +1 more source

TRPM8 and TRPM2 ion channels determine sex differences in thermal preference in mice

The Journal of Physiology, EarlyView.
Abstract figure legend Too hot or too cold? How do we know? Animals seek a ‘comfort temperature’ in between ‘too hot’ (far left) and ‘too cold’ (far right). In mammals and birds, females (left) prefer warmer temperatures than males (right). We show here that in mice, the comfort temperature is determined by a balance of sensory input (black arrows ...
Bruno Vilar, Peter A. McNaughton
wiley   +1 more source

The TRPM2 channel: A thermo-sensitive metabolic sensor [PDF]

Channels, 2017
Living organisms continually experience changes in ambient temperature. To detect such temperature changes for adaptive behavioral responses, we evolved the ability to sense temperature. Thermosensitive transient receptor potential (TRP) channels, so-called thermo-TRPs, are involved in many physiologic functions in diverse organisms and constitute ...
Makiko, Kashio, Makoto, Tominaga
openaire   +2 more sources

Long non-coding TRPM2-AS regulates fracture healing by targeting miR-545-3p/Bmp2

Journal of Orthopaedic Surgery and Research
Objective Delayed fracture healing increases the suffering of patients. An in-depth investigation of the pathogenesis of delayed fracture healing may offer new direction for the prevention and treatment.
Renjie Kang, Lina Huang, Teng Zeng, Jinliang Ma, Danjie Jin   +4 more
doaj   +1 more source