Results 31 to 40 of about 1,608 (146)

The vital role of TRPM2 in breast cancer cell proliferation and its difference in expression between non-Hispanic white and non-Hispanic black females [PDF]

World Cancer Research Journal
Objective: To study the racial disparity of transient receptor potential melastatin-related channel subtype 2 (TRPM2) expression in non-Hispanic black (NHB) women and non-Hispanic white women (NHW) breast cancer tissues.
L. Huang, Y. Lu, M. Li
doaj   +1 more source

Crosstalk Between Vascular Redox and Calcium Signaling in Hypertension Involves TRPM2 (Transient Receptor Potential Melastatin 2) Cation Channel

, 2020
Increased generation of reactive oxygen species (ROS) and altered Ca2+ handling cause vascular damage in hypertension. Mechanisms linking these systems are unclear, but TRPM2 (transient receptor potential melastatin 2) could be important because TRPM2 is
Karla B. Neves, Aikaterini Anagnostopoulou, Rhian M. Touyz, Rhéure Alves-Lopes, Silvia Lacchini, Augusto C. Montezano, Francisco J. Rios   +6 more
core   +1 more source

Alteration in Intracellular Zn2+ Homeostasis as a Result of TRPM2 Channel Activation Contributes to ROS-Induced Hippocampal Neuronal Death

Frontiers in Molecular Neuroscience, 2017
Transient receptor potential melastatin-related 2 (TRPM2) channel, a molecular sensor for reactive oxygen species (ROS), plays an important role in cognitive dysfunction associated with post-ischemia brain damage thought to result from ROS-induced TRPM2 ...
Xin Li, Wei Yang, Wei Yang, Lin-Hua Jiang, Lin-Hua Jiang   +4 more
doaj   +1 more source

Identification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancer

Journal of Ovarian Research, 2023
Introduction Ovarian cancer (OC) is one of the most common gynecologic malignant cancers with the current survival rate remaining low. TRPM2 has been reported as a survival predictor in various cancers but not in OC.
Wei Huang, Yuliang Wu, Ning Luo, Xueqian Shuai, Jing Guo, Chunyan Wang, Fanchun Yang, Li Liu, Shupeng Liu, Zhongping Cheng   +9 more
doaj   +1 more source

Activators of TRPM2: Getting it right [PDF]

Journal of General Physiology, 2015
The conclusions we draw regarding the molecular mechanisms that govern ion channel activation rely on both careful experimental design and meticulous analysis and interpretation of the data. A new study on agonist activation of TRPM2 ion channels exemplifies how a rigorous biophysical approach can provide definitive answers to a previously murky ...
openaire   +2 more sources

Structures and gating mechanism of human TRPM2 [PDF]

Science, 2018
Architecture of the human TRPM2 channel Adenosine diphosphate–ribose (ADPR) mediates calcium (Ca 2+ ) release by activating the transient receptor potential melastatin 2 (TRPM2) channel. Three structures now elucidate the conformational regulation mechanism of TRPM2 gating. Wang et al.
Longfei Wang, Tian-Min Fu, Yiming Zhou, Shiyu Xia, Anna Greka, Hao Wu   +5 more
openaire   +2 more sources

Involvement of TRPM2 in a wide range of inflammatory and neuropathic pain mouse models

Journal of Pharmacological Sciences, 2015
Recent evidence suggests a role of transient receptor potential melastatin 2 (TRPM2) in immune and inflammatory responses. We previously reported that TRPM2 deficiency attenuated inflammatory and neuropathic pain in some pain mouse models, including ...
Kanako So, Kayo Haraguchi, Kayoko Asakura, Koichi Isami, Shinya Sakimoto, Hisashi Shirakawa, Yasuo Mori, Takayuki Nakagawa, Shuji Kaneko   +8 more
doaj   +1 more source

Regulation of TRPM2 by Extra- and Intracellular Calcium [PDF]

The Journal of General Physiology, 2007
TRPM2 is a calcium-permeable nonselective cation channel that is opened by the binding of ADP-ribose (ADPR) to a C-terminal nudix domain. Channel activity is further regulated by several cytosolic factors, including cyclic ADPR (cADPR), nicotinamide adenine dinucleotide phosphate (NAADP), Ca2+ and calmodulin (CaM), and adenosine monophosphate (AMP). In
Starkus, John, Beck, Andreas, Fleig, Andrea, Penner, Reinhold   +3 more
openaire   +2 more sources

The Janus-faced role of TRPM2-S in retroperitoneal liposarcoma via increasing ROS levels

Cell Communication and Signaling, 2022
Background Retroperitoneal liposarcoma (RPLS) is a specific soft tissue sarcoma with a high recurrence rate. The short isoform of transient receptor potential cation channel subfamily M member 2 (TRPM2-S) plays an important role in the regulation of ...
Xiangji Li, Fanqin Bu, Shixiang Ma, Ferdinando Cananzi, Yu Zhao, Mengmeng Xiao, Li Min, Chenghua Luo   +7 more
doaj   +1 more source

TRPM2 exacerbates airway inflammation by regulating oxidized-CaMKⅡ in allergic asthma

Heliyon
Background: Airway epithelial cells play important roles in allergic asthma. Transient receptor potential melastatin-related 2 (TRPM2) and oxidized Ca2+/calmodulin-dependent protein kinase Ⅱ (ox-CaMKⅡ) participate in the airway inflammation.
Xueping Liu, Lingyan Zhao, Rui Wang, Zhaoying Tang   +3 more
doaj   +1 more source