Results 41 to 50 of about 1,695 (109)

Flow cytometry analysis of BM-derived cells in WT/TRPM2-KO BM chimeric mice.

, 2013
Representative histograms of GFP+ cells in WT mice (A; negative control), GFP-transgenic mice (B; positive control), TRPM2BM+/Rec+ mice (C), TRPM2BM–/Rec+ mice (D), TRPM2BM+/Rec– mice (E), and TRPM2BM-/Rec– mice (F).
Kanako So (439401), Shuji Kaneko (203005), Hisashi Shirakawa (203001), Takayuki Nakagawa (202988), Kayoko Asakura (439402), Kayo Haraguchi (439400), Kouichi Isami (439399), Yasuo Mori (320114)   +7 more
core   +1 more source

Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death

Cells, 2019
Human neuroblastoma SH-SY5Y cells are a widely-used human neuronal cell model in the study of neurodegeneration. A recent study shows that, 1-methyl-4-phenylpyridine ion (MPP), which selectively causes dopaminergic neuronal death leading to Parkinson ...
Xinfang An, Zixing Fu, Chendi Mai, Weiming Wang, Linyu Wei, Dongliang Li, Chaokun Li, Lin-Hua Jiang   +7 more
doaj   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub

Cancer Science, EarlyView.
PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley   +1 more source

Peripheral nerve injury-induced mechanical allodynia in WT/TRPM2-KO BM chimeric mice.

, 2013
In the pSNL model of neuropathic pain, the 50% withdrawal threshold to mechanical stimuli was determined in the ipsilateral (A) and contralateral paws (B) of TRPM2BM+/Rec+, TRPM2BM–/Rec+, TRPM2BM+/Rec–, and TRPM2BM+/Rec+ mice. *p < 0.05; **p < 0.01; ***p
Kanako So (439401), Shuji Kaneko (203005), Hisashi Shirakawa (203001), Takayuki Nakagawa (202988), Kayoko Asakura (439402), Kayo Haraguchi (439400), Kouichi Isami (439399), Yasuo Mori (320114)   +7 more
core   +1 more source

Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers

Technology in Cancer Research & Treatment
Long non-coding RNAs (lncRNAs) are known to play vital roles in human cancers. LncRNA TRPM2-AS has been found to be upregulated in various types of cancers. The elevated levels of TRPM2-AS are associated with important clinicopathological parameters such
Shichen Huang MS, Bowen Li MS, Huanyu Chen MD, Cheng Rong, Zheng Yang MD, Xianqin Zhang PhD   +5 more
doaj   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket

Cell Reports, 2019
Summary: cADPR is a well-recognized signaling molecule by modulating the RyRs, but considerable debate exists regarding whether cADPR can bind to and gate the TRPM2 channel, which mediates oxidative stress signaling in diverse physiological and ...
Peilin Yu, Zhenming Liu, Xiafei Yu, Peiwu Ye, Huan Liu, Xiwen Xue, Lixin Yang, Zhongtang Li, Yang Wu, Cheng Fang, Yong Juan Zhao, Fan Yang, Jian Hong Luo, Lin-Hua Jiang, Liangren Zhang, Lihe Zhang, Wei Yang   +16 more
doaj   +1 more source

Extinction of contextual fear memory is facilitated in TRPM2 knockout mice

Molecular Brain
Transient receptor potential melastatin type 2 (TRPM2) is a nonselective cation channel involved in synaptic plasticity. We investigated its role in contextual fear conditioning and extinction of conditioned fear using Trpm2-deficient (Trpm2 −/− ) mice ...
Seung Yeon Ko, Do Gyeong Kim, Huiju Lee, Sung Jun Jung, Hyeon Son   +4 more
doaj   +1 more source

Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

Molecular Brain, 2012
Background Glutathione (GSH) plays an important role in neuronal oxidant defence. Depletion of cellular GSH is observed in neurodegenerative diseases and thereby contributes to the associated oxidative stress and Ca2+ dysregulation.
Belrose Jillian C, Xie Yu-Feng, Gierszewski Lynn J, MacDonald John F, Jackson Michael F   +4 more
doaj   +1 more source