Results 61 to 70 of about 1,608 (146)

Extinction of contextual fear memory is facilitated in TRPM2 knockout mice

Molecular Brain
Transient receptor potential melastatin type 2 (TRPM2) is a nonselective cation channel involved in synaptic plasticity. We investigated its role in contextual fear conditioning and extinction of conditioned fear using Trpm2-deficient (Trpm2 −/− ) mice ...
Seung Yeon Ko, Do Gyeong Kim, Huiju Lee, Sung Jun Jung, Hyeon Son   +4 more
doaj   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Assessment of temperature sensitivity of the TRPM2 channel [PDF]

, 2021
TRPM2 belongs to the TRP family, and is expressed in neurons of the central nervous system, bone marrow, phagocytes, β-cells, and cardiomyocytes. It forms Ca2+-permeable nonselective cation channels that open under oxidative stress by simultaneous ...
Csanády, László, Bartok, Adam
core   +1 more source

Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

Molecular Brain, 2012
Background Glutathione (GSH) plays an important role in neuronal oxidant defence. Depletion of cellular GSH is observed in neurodegenerative diseases and thereby contributes to the associated oxidative stress and Ca2+ dysregulation.
Belrose Jillian C, Xie Yu-Feng, Gierszewski Lynn J, MacDonald John F, Jackson Michael F   +4 more
doaj   +1 more source

Renin‐Angiotensin Signaling and Vascular Function: Insights into Health and Disease

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Giovanni Bertoldi, Swapnil K. Sonkusare
wiley   +1 more source

Inactivation of TRPM2 Channels by Extracellular Divalent Copper

PLoS ONE, 2014
Cu2+ is an essential metal ion that plays a critical role in the regulation of a number of ion channels and receptors in addition to acting as a cofactor in a variety of enzymes. Here, we showed that human melastatin transient receptor potential 2 (hTRPM2) channel is sensitive to inhibition by extracellular Cu2+.
Yu, W, Jiang, L-H, Zheng, Y, Hu, X, Luo, J, Yang, W   +5 more
openaire   +5 more sources

The PKC/NOX/ROS and PYK2/MEK/ERK/PARP signalling pathways drive TRPM2 channel activation induced by non-cytolytic oxidative stress in microglial cells

Redox Report
Objectives The study aimed to investigate the signalling mechanism for TRPM2 channel activation by non-cytolytic oxidative stress in microglia.Methods Microglia from wild-type (WT) and TRPM2-knockout (KO) mice were exposed to 10-30 mM H2O2 for up to 24 ...
Sharifah Alawieyah Syed Mortadza, Nur Zulaikha Mohamad Zahir, Chew Tze Wei, Lin-Hua Jiang   +3 more
doaj   +1 more source

Molecular Regulations and Functions of the Transient Receptor Potential Channels of the Islets of Langerhans and Insulinoma Cells

Cells, 2020
Insulin secretion from the β-cells of the islets of Langerhans is triggered mainly by nutrients such as glucose, and incretin hormones such as glucagon-like peptide-1 (GLP-1).
Md. Shahidul Islam
doaj   +1 more source

LncTRPM2-AS inhibits TRIM21-mediated TRPM2 ubiquitination and prevents autophagy-induced apoptosis of macrophages in asthma

Cell Death and Disease, 2021
Long non-coding RNAs (lncRNAs) play a crucial role in macrophage development but little is known about their role in asthma. Here, we investigated the role of lncRNA lncTRPM2-AS in asthma and found that lncTRPM2-AS participates in the promotion of ...
Xiaoping Li, Wenwen Wang, Yu Shao, Ji Zhou, Jiaqi Huang, Fei Xu, Xiu Gao, Mengyun Wu, Yongli Dong, Wenyan Wu, Jiamin Cai, Junyao Wang, Yunfei Ye, Zhengrong Chen, Chuangli Hao, Yi Yang, Jinping Zhang   +16 more
doaj   +1 more source

The TRPM2–PARP‐1 Axis Involvement in Bisphenol A and Nonylphenol‐Induced Ferroptosis in Trigeminal Ganglion Cells

Journal of Applied Toxicology, Volume 46, Issue 10, Page 3660-3674, October 2026.
ABSTRACT Environmental contaminants like bisphenol A (BPA) and nonylphenol (NP) are recognized neurotoxicants; however, the molecular mechanisms underlying their impact on sensory ganglia, specifically the trigeminal ganglion (TG), remain critically underexplored.
Betül Yazğan, Musa Tatar, Yener Yazğan, Kıymet Kübra Tüfekci   +3 more
wiley   +1 more source