Results 61 to 70 of about 1,695 (109)

A novel mechanism of imeglimin‐mediated insulin secretion via the cADPR‐TRP channel pathway

Journal of Diabetes Investigation, 2022
Aims/Introduction Imeglimin is a novel oral hypoglycemic agent that improves blood glucose levels through multiple mechanisms of action including the enhancement of glucose‐stimulated insulin secretion (GSIS), however, the details of this mechanism have ...
Shunsuke Funazaki, Masashi Yoshida, Hodaka Yamada, Masafumi Kakei, Masanobu Kawakami, Shuichi Nagashima, Kazuo Hara, Katsuya Dezaki   +7 more
doaj   +1 more source

Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurons

, 2006
TRPM2, a member of the TRP ion channel family, is expressed both in the brain and immune cells of the monocyte lineage. Functionally, it is unique in its activation by intracellular ADP-ribose and both oxidative and nitrosative stress. To date studies of
Benham, C.D., Randall, A.D., McNulty, S., Schaefer, M., Tigue, N., Hill, K., Kelsell, R.E.   +6 more
core   +2 more sources

Multi‐omics–driven precision medicine

iMeta, Volume 5, Issue 5, October 2026.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

TRPM2 exacerbates central nervous system inflammation in experimental autoimmune encephalomyelitis by increasing production of CXCL2 chemokines [PDF]

, 2018
多発性硬化症の新たな病態増悪機構を解明 --TRPM2を介したケモカイン産生が神経炎症の増悪に至る好中球の浸潤を引き起こす--. 京都大学プレスリリース. 2018-09-13.Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS) characterized by demyelination and axonal injury.
Nakagawa, Takayuki, Tsutsui, Masato, Miyamura, Sakie, Kaneko, Shuji, Nagayasu, Kazuki, Hirase, Ryo, Shirakawa, Hisashi, Mori, Yasuo   +7 more
core   +1 more source

Pathophysiological significance of the TRPM2 ion channel as a potential target in cancer, neurological disorders, and ischemia/reperfusion injury

Pharmacological Research
The transient receptor potential melastatin 2 (TRPM2) ion channel is a redox-sensitive, non-specific cation channel that plays a vital role in the regulation of Ca2+ homeostasis and cellular functions in response to oxidative stress.
Sara Sultana, Yang Xie, Mir Shahriar Kamal, Wei Li   +3 more
doaj   +1 more source

Targeting TRPM2 in ROS-Coupled Diseases

Pharmaceuticals, 2016
Under pathological conditions such as inflammation and ischemia-reperfusion injury large amounts of reactive oxygen species (ROS) are generated which, in return, contribute to the development and exacerbation of disease.
Shinichiro Yamamoto, Shunichi Shimizu
doaj   +1 more source

The TRPM2–PARP‐1 Axis Involvement in Bisphenol A and Nonylphenol‐Induced Ferroptosis in Trigeminal Ganglion Cells

Journal of Applied Toxicology, Volume 46, Issue 10, Page 3660-3674, October 2026.
ABSTRACT Environmental contaminants like bisphenol A (BPA) and nonylphenol (NP) are recognized neurotoxicants; however, the molecular mechanisms underlying their impact on sensory ganglia, specifically the trigeminal ganglion (TG), remain critically underexplored.
Betül Yazğan, Musa Tatar, Yener Yazğan, Kıymet Kübra Tüfekci   +3 more
wiley   +1 more source

Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies

MedComm, Volume 7, Issue 10, October 2026.
Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng, Qi Qin, Fang Wang, Kaiyuan Zhang, Zhihua Li, Junlei Chang, Min Yu, Fuyou Guo   +7 more
wiley   +1 more source

TRPM2 ION CHANNEL REGULATES CANCER CELL SURVIVAL IN A CALCIUM-DEPENDENT MANNER

, 2018
Since the late 1990s, TRPM2 ion channels have been broadly studied in various cancer types. The positive effect of TRPM2 expression on cancer cell viability has been associated with reduced cancer patient survival.
Almasi, Shekoufeh
core  

2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist [PDF]

, 2017
Transient receptor potential melastatin 2 (TRPM2), is a ligand-gated Ca2+-permeable non selective cation channel. While physiological stimuli, e.g. chemotactic agents, evoke controlled Ca2+ signals via TRPM2, pathophysiological signals, such as reactive ...
Christelle Moreau, Wolters, Valerie, Barry V L Potter, Andreas H Guse, Monika D Rozewitz, Mareike Janus, Marianne Flato, Janus, Mareike, Rozewitz, Monika D., Kirchberger, Tanja, Joanna M Watt, Fliegert, Ralf, Tanja Kirchberger, Moreau, Christelle, Harneit, Angelika, Guse, Andreas H, Watt, Joanna M, Winzer, Riekje, Valerie Wolters, Annette Rosche, Feng Gu, Potter, Barry V. L., Bauche, Andreas, Ralf Fliegert, Andreas Bauche, Riekje Winzer, Rosche, Annette, Wolf Pérez, Adriana-Michelle, Flato, Marianne, Gu, Feng, Adriana-Michelle Wolf Pérez, Angelika Harneit   +31 more
core   +1 more source