Results 71 to 80 of about 1,695 (109)

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

Advanced Science, Volume 13, Issue 54, 28 September 2026.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li, Yuxuan Ma, Di He, Yingying Huang, Yutong Jiang, He Zhao, Shengjie Ge, Ruirui Zhao, Hejia Yuan, Wendi Jiang, Wenjun Zhu, Kai Liu, Han Zhang, Zhuang Liu   +13 more
wiley   +1 more source

Knee Osteoarthritis Therapy Targeting NLRP3 Inflammasome: Progress From Mechanism to Application

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective This paper briefly reviews the structure, function, and activation mechanism of the NLRP3 inflammasome and its molecular role in the pathogenesis of knee osteoarthritis (KOA), and explores the potential value of traditional Chinese medicine (TCM) in treating KOA by modulating NLRP3 inflammasome activity.
Wenguang Chen, Baoxiu Yi, Zhang Wang, Cong Yu, Ziru Li, Zenan Wu, Ensi Hong   +6 more
wiley   +1 more source

Dexmedetomidine protects against ischemia and reperfusion-induced kidney injury in rats by inhibiting the expression of TRPM2 and TRPA1 channels [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Renal ischemia and reperfusion (I/R) injury is a potentially serious issue encountered during various medical and surgical procedures. This condition is clinically significant because of its high incidence and mortality rate. In this study,
Abdulkadir Uzunboy, Tuncay Kuloglu, Oguzhan Demirel, Ahmet TURK, Gulsum Altuntas, Esef Bolat   +5 more
doaj   +1 more source

Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients

Journal of Translational Medicine, 2019
Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is hallmarked by a significant reduction in natural killer (NK) cell cytotoxicity, a mechanism tightly regulated by calcium (Ca2+).
Cassandra Balinas, Helene Cabanas, Donald Staines, Sonya Marshall-Gradisnik   +3 more
doaj   +1 more source

A critical role of TRPM2 channel in Aβ₄₂‐induced microglial activation and generation of tumor necrosis factor‐α [PDF]

, 2017
Amyloid β (Aβ)‐induced neuroinflammation plays an important part in Alzheimer's disease (AD). Emerging evidence supports a role for the transient receptor potential melastatin‐related 2 (TRPM2) channel in Aβ‐induced neuroinflammation, but how Aβ induces ...
Alawieyah Syed Mortadza, S., Jiang, L.H., Sim, J.A., Neubrand, Veronika E., Jiang, L-H, Sim, JA, Neubrand, VE, Lin-Hua Jiang, Veronika E. Neubrand, Sharifah Alawieyah Syed Mortadza, Mortadza, SAS, Joan A. Sim   +11 more
core   +1 more source

Ionic signalling and mitochondrial dynamics

Molecular & Cellular Oncology, 2017
In age-related diseases, rise in intracellular reactive oxygen species (ROS) causes fragmentation of mitochondrial network. Our recent study demonstrated that ROS activation of TRPM2 (transient receptor potential melastatin-2) channels triggers lysosomal
Nada Abuarab, Fangfang Li, Asipu Sivaprasadarao   +2 more
doaj   +1 more source

PARP1, TRPM2 and redox signalling in hypertension-associated vascular dysfunction

, 2018
While oxidative stress and dysregulation of Ca2+ homeostasis in vascular signalling are hallmarks of hypertension-associated vascular injury, downstream molecular mechanisms that govern reactive oxygen species (ROS)-dependent regulation of ion channels ...
Dulak-Lis, Maria Gabriela
core   +1 more source

Hypoxic Stress Induces Transient Receptor Potential Melastatin 2 (TRPM2) Channel Expression in Adult Rat Cardiac Fibroblasts

Journal of Pharmacological Sciences, 2012
When cardiac tissue is exposed to hypoxia, myocytes are damaged, while fibroblasts are activated. However, it is unknown what changes are induced by hypoxia in cardiac fibroblasts.
Kenji Takahashi, Kazuho Sakamoto, Junko Kimura   +2 more
doaj   +1 more source

Glutathione Depletion and Parkinsonian Neurotoxin MPP+-Induced TRPM2 Channel Activation Play Central Roles in Oxidative Cytotoxicity and Inflammation in Microglia

, 2020
Parkinson's disease (PD) is one of most common neurodegenerative diseases. Environmental stressors such as oxidative stress (OS), calcium ion influx, apoptosis, and inflammation mechanisms are linked to activated microglia in patients with PD.
Nazıroğlu, Mustafa, Yıldızhan, Kenan, NAZIROĞLU, Mustafa   +2 more
core   +1 more source

LncRNA TRPM2-AS promotes endometrial carcinoma progression and angiogenesis via targeting miR-497-5p/SPP1 axis

Cellular & Molecular Biology Letters
Background Anti-angiogenic therapy has become one of the effective treatment methods for tumors. Long noncoding RNAs (lncRNAs) are emerging as important regulators of tumorigenesis and angiogenesis in EC.
Hanbo Ma, Fengyun Weng, Xiaowen Tong, Huaifang Li, Yinan Yao, Jiangjing Yuan   +5 more
doaj   +1 more source