Results 71 to 80 of about 1,608 (146)

A novel mechanism of imeglimin‐mediated insulin secretion via the cADPR‐TRP channel pathway

Journal of Diabetes Investigation, 2022
Aims/Introduction Imeglimin is a novel oral hypoglycemic agent that improves blood glucose levels through multiple mechanisms of action including the enhancement of glucose‐stimulated insulin secretion (GSIS), however, the details of this mechanism have ...
Shunsuke Funazaki, Masashi Yoshida, Hodaka Yamada, Masafumi Kakei, Masanobu Kawakami, Shuichi Nagashima, Kazuo Hara, Katsuya Dezaki   +7 more
doaj   +1 more source

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

Advanced Science, Volume 13, Issue 54, 28 September 2026.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li, Yuxuan Ma, Di He, Yingying Huang, Yutong Jiang, He Zhao, Shengjie Ge, Ruirui Zhao, Hejia Yuan, Wendi Jiang, Wenjun Zhu, Kai Liu, Han Zhang, Zhuang Liu   +13 more
wiley   +1 more source

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

eLife, 2018
Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable cation channel required for immune cell activation, insulin secretion, and body heat control.
Zhe Zhang, Balázs Tóth, Andras Szollosi, Jue Chen, László Csanády   +4 more
doaj   +1 more source

Knee Osteoarthritis Therapy Targeting NLRP3 Inflammasome: Progress From Mechanism to Application

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective This paper briefly reviews the structure, function, and activation mechanism of the NLRP3 inflammasome and its molecular role in the pathogenesis of knee osteoarthritis (KOA), and explores the potential value of traditional Chinese medicine (TCM) in treating KOA by modulating NLRP3 inflammasome activity.
Wenguang Chen, Baoxiu Yi, Zhang Wang, Cong Yu, Ziru Li, Zenan Wu, Ensi Hong   +6 more
wiley   +1 more source

The TRPM2 channel: A thermo-sensitive metabolic sensor [PDF]

Channels, 2017
Living organisms continually experience changes in ambient temperature. To detect such temperature changes for adaptive behavioral responses, we evolved the ability to sense temperature. Thermosensitive transient receptor potential (TRP) channels, so-called thermo-TRPs, are involved in many physiologic functions in diverse organisms and constitute ...
Makiko, Kashio, Makoto, Tominaga
openaire   +2 more sources

Tyrphostin AG-related compounds attenuate H2O2-induced TRPM2-dependent and -independent cellular responses

Journal of Pharmacological Sciences, 2017
Purpose: TRPM2 is a Ca2+-permeable channel that is activated by H2O2. TRPM2-mediated Ca2+ signaling has been implicated in the aggravation of inflammatory diseases.
Shinichiro Yamamoto, Takahiro Toda, Ryo Yonezawa, Takaharu Negoro, Shunichi Shimizu   +4 more
doaj   +1 more source

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source

In with the TRP Channels: Intracellular Functions for TRPM1 and TRPM2 [PDF]

Science Signaling, 2009
Cationic channels of the TRP melastatin family are involved in pigmentation and oxidative stress responses.
Sandip, Patel, Roberto, Docampo
openaire   +2 more sources

Intracellular calcium activates TRPM2 and its alternative spliced isoforms

, 2009
Melastatin-related transient receptor potential channel 2 (TRPM2) is a Ca(2+)-permeable, nonselective cation channel that is involved in oxidative stress-induced cell death and inflammation processes.
Yue, Lixia, Du, Jianyang, Xie, Jia
core   +1 more source

Pathophysiological significance of the TRPM2 ion channel as a potential target in cancer, neurological disorders, and ischemia/reperfusion injury

Pharmacological Research
The transient receptor potential melastatin 2 (TRPM2) ion channel is a redox-sensitive, non-specific cation channel that plays a vital role in the regulation of Ca2+ homeostasis and cellular functions in response to oxidative stress.
Sara Sultana, Yang Xie, Mir Shahriar Kamal, Wei Li   +3 more
doaj   +1 more source