Results 101 to 110 of about 1,608 (146)

Effect of astaxanthin in imatinib mesylate-induced cardiotoxicity

Acta Medica Alanya, 2020
Aim: Imatinib mesylate is a tyrosine kinase inhibitor and is approved as a standard first-line therapy of chronic myeloid leukemia. Oxidative stress, as well as intracellular calcium overload and mitochondrial dysfunction, play an important role in ...
İshak Suat Övey, Can Ramazan Öncel
doaj  

The TRPM2 channel in temperature detection and thermoregulation [PDF]

Temperature, 2016
Gretel B. Kamm, Jan Siemens
openaire   +3 more sources

TRPM2 channels in mitochondrial dynamics and cancer [PDF]

Oncotarget, 2017
Sivaprasadarao, A, Abuarab, N, Li, F
openaire   +3 more sources

Astroglial CD38 impairs hippocampal synaptic plasticity after global cerebral ischemia

Frontiers in Stroke
Cardiac arrest-induced global cerebral ischemia (GCI) results in profound cognitive impairment in survivors. Our prior work demonstrated persistent disruption of long-term potentiation (LTP) in hippocampal CA1 neurons, correlating with learning and ...
Amelia M. Burch, Ami Haas, James E. Orfila, Erika Tiemeier, Cassidy De Anda Gamboa, Nicholas Chalmers, Nidia Quillinan, Paco S. Herson   +7 more
doaj   +1 more source

Identification of novel sense and antisense transcription at the TRPM2 locus in cancer

, 2008
It has been proposed that in cancer, where the bulk of the genome becomes hypomethylated, there is an increase in transcriptional noise that might lead to the generation of antisense transcripts that could affect the function of key oncosuppressor genes,
Ugo Orfanelli, Orfanelli, Ugo, Ann-Kathrin Wenke, DOGLIONI , CLAUDIO, Doglioni, Claudio, Wenke Ann Kathrin, Lavorgna Giovanni, Wenke, Ann-Kathrin, Vincenzo Russo, Claudio Doglioni, Orfanelli Ugo, Anja Katrin Bosserhoff, Lavorgna, Giovanni, Russo, Vincenzo, Bosserhoff Anja Katrin, Giovanni Lavorgna, Bosserhoff, Anja Katrin, Russo Vincenzo   +17 more
core   +1 more source

TRPM2 and biliary acute pancreatitis [PDF]

The Journal of Physiology, 2020
openaire   +4 more sources

TRPM2 is a Direct Pain Transducer

Abstract Chronic pain results from maladaptive interaction between the immune and nervous systems. TRPM2 channels in immune cells (immune TRPM2) are believed to facilitate chronic pain by indirectly promoting immune-inflammatory responses.
Linda Varghese, Mujahid Alizada, Jinquan Yang, Ye Feng, Mitali Malhotra, Xuming Zhang   +5 more
openaire   +1 more source

TLR4 induced TRPM2 mediated neuropathic pain

Frontiers in Pharmacology
Ion channels play an important role in mediating pain through signal transduction, regulation, and control of responses, particularly in neuropathic pain. Transient receptor potential channel superfamily plays an important role in cation permeability and cellular signaling.
Venkata Kiran Kumar Mandlem, Ana Rivera, Zaina Khan, Zaina Khan, Sohel H. Quazi, Sohel H. Quazi, Farah Deba   +6 more
openaire   +3 more sources

TRPM2: a pivotal player in tumor progression and a promising therapeutic target

Cancer Cell International
TRPM2, a member of the TRPM family, is a ubiquitously expressed non-selective cation channel located on cellular membranes. Activated by ADP-ribose (ADPR), this channel is prevalent across various normal tissues and plays a critical role in numerous ...
Zhigang Chen, Zhenheng Wu, Tianhan Xu, Fuqian Yu, Dongmei Wang   +4 more
doaj   +1 more source

Long non-coding TRPM2-AS regulates fracture healing by targeting miR-545-3p/Bmp2

Journal of Orthopaedic Surgery and Research
Objective Delayed fracture healing increases the suffering of patients. An in-depth investigation of the pathogenesis of delayed fracture healing may offer new direction for the prevention and treatment.
Renjie Kang, Lina Huang, Teng Zeng, Jinliang Ma, Danjie Jin   +4 more
doaj   +1 more source