Results 81 to 90 of about 1,695 (109)
Frontiers in ImmunologyTransient receptor potential melastatin 2 (TRPM2) is a non-selective cation channel that exhibits Ca2+ permeability. The TRPM2 channel is expressed in various tissues and cells and can be activated by multiple factors, including endogenous ligands, Ca2+,
Peng Huang +8 more
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Investigation Into the Pathogenesis of Type 2 Cardiorenal Syndrome via the ROS–TRPM2 Signaling Axis
Frontiers in Bioscience-LandmarkBackground: Type 2 cardiorenal syndrome (CRS) is a complex disease characterized by the interplay between the heart and kidneys. The pathophysiology of type 2 CRS involves multiple molecular signaling pathways.
Yanxia Li, Fengrong Wang
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Intracellular calcium activates TRPM2 and its alternative spliced isoforms
, 2009 Melastatin-related transient receptor potential channel 2 (TRPM2) is a Ca(2+)-permeable, nonselective cation channel that is involved in oxidative stress-induced cell death and inflammation processes.
Yue, Lixia +5 more
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Effect of astaxanthin in imatinib mesylate-induced cardiotoxicity
Acta Medica Alanya, 2020 Aim: Imatinib mesylate is a tyrosine kinase inhibitor and is approved as a standard first-line therapy of chronic myeloid leukemia. Oxidative stress, as well as intracellular calcium overload and mitochondrial dysfunction, play an important role in ...
İshak Suat Övey, Can Ramazan Öncel
doaj
Astroglial CD38 impairs hippocampal synaptic plasticity after global cerebral ischemia
Frontiers in StrokeCardiac arrest-induced global cerebral ischemia (GCI) results in profound cognitive impairment in survivors. Our prior work demonstrated persistent disruption of long-term potentiation (LTP) in hippocampal CA1 neurons, correlating with learning and ...
Amelia M. Burch +7 more
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, 2006 TRPM2, a member of the TRP ion channel family, is expressed both in the brain and immune cells of the monocyte lineage. Functionally, it is unique in its activation by intracellular ADP-ribose and both oxidative and nitrosative stress. To date studies of
Schaefer, M +6 more
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LifeThe channel TRPM2 forms cation-selective channels and is activated by redox-dynamics, including oxidative stress. Initially described at the plasma membrane, TRPM2 has been found to also localized to intracellular compartments, i.e., nucleus ...
Alice Hasselsweiller +3 more
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TRPM2: a pivotal player in tumor progression and a promising therapeutic target
Cancer Cell InternationalTRPM2, a member of the TRPM family, is a ubiquitously expressed non-selective cation channel located on cellular membranes. Activated by ADP-ribose (ADPR), this channel is prevalent across various normal tissues and plays a critical role in numerous ...
Zhigang Chen +4 more
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Cell surface expression of TRPM2 variants.
, 2013 (A) Western blots were performed on two different membrane fractions of HEK-293 cells transfected with a TRPM2 variant and probed with a commercially available anti-TRPM2 antibody. Mock-transfected cells were used as negative control.
Mathis Winking (297698) +5 more
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Long non-coding TRPM2-AS regulates fracture healing by targeting miR-545-3p/Bmp2
Journal of Orthopaedic Surgery and ResearchObjective Delayed fracture healing increases the suffering of patients. An in-depth investigation of the pathogenesis of delayed fracture healing may offer new direction for the prevention and treatment.
Renjie Kang +4 more
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