Results 91 to 100 of about 1,608 (146)

Uncovering the Role of TRPM2 in TNBC

Breast cancer has high mortality in women worldwide and is a complex disease. Specifically, TNBC is an aggressive subtype which lacks a unique therapeutic target.
Maliougina, Maria
core   +2 more sources

TRPM2 overactivation drives hyperlipidemia-induced dysfunction of myeloid cells and neurovascular units

Cell Reports Medicine
Summary: Hyperlipidemia induces cellular dysfunction and is strongly linked to various diseases. The transient receptor potential channel melastatin 2 (TRPM2) plays a critical role in endothelial injury, immune cell activation, and neuronal death.
Pengyu Zong, Cindy Li, Jianlin Feng, Zhichao Yue, Nicholas Legere, Albert S. Yu, Fahad Shah, Adrianna Perez, Zhu Li, Evan Jellison, Yasuo Mori, Barbara Miller, Rajkumar Verma, Bruce Liang, Lixia Yue   +14 more
doaj   +1 more source

Hypoxic Stress Induces Transient Receptor Potential Melastatin 2 (TRPM2) Channel Expression in Adult Rat Cardiac Fibroblasts

Journal of Pharmacological Sciences, 2012
When cardiac tissue is exposed to hypoxia, myocytes are damaged, while fibroblasts are activated. However, it is unknown what changes are induced by hypoxia in cardiac fibroblasts.
Kenji Takahashi, Kazuho Sakamoto, Junko Kimura   +2 more
doaj   +1 more source

LncRNA TRPM2-AS promotes endometrial carcinoma progression and angiogenesis via targeting miR-497-5p/SPP1 axis

Cellular & Molecular Biology Letters
Background Anti-angiogenic therapy has become one of the effective treatment methods for tumors. Long noncoding RNAs (lncRNAs) are emerging as important regulators of tumorigenesis and angiogenesis in EC.
Hanbo Ma, Fengyun Weng, Xiaowen Tong, Huaifang Li, Yinan Yao, Jiangjing Yuan   +5 more
doaj   +1 more source

Der TRPM2 Ionen Kanal in Nukleotid gesteuerten Kalziumsignal Netzwerken

, 2008
TRPM2, a member of the transient receptor potential family, is a widely expressed Ca2+-permeable, non-selective cation channel that is specifically activated by ADP-ribose (ADPR) at its unique enzymatic pyrophosphatase domain.
Lange, Ingo
core   +1 more source

Bidirectional regulation mechanism of TRPM2 channel: role in oxidative stress, inflammation and ischemia-reperfusion injury

Frontiers in Immunology
Transient receptor potential melastatin 2 (TRPM2) is a non-selective cation channel that exhibits Ca2+ permeability. The TRPM2 channel is expressed in various tissues and cells and can be activated by multiple factors, including endogenous ligands, Ca2+,
Peng Huang, Peng Huang, Chaoyi Qu, Zhijian Rao, Zhijian Rao, Dongzhe Wu, Dongzhe Wu, Jiexiu Zhao, Jiexiu Zhao   +8 more
doaj   +1 more source

Charakterisierung von TRPM2-Ligandenbindedomänen und der P2X7 Ballast-Domäne

, 2022
The ion channels TRPM2 (transient receptor potential melastatin 2) and P2X7 (P2X purinoreceptor 7) are key players in immunity and inflammation and are both activated by adenine nucleotides: TRPM2 by ADPR (adenosine diphosphate ribose), and P2X7 by ATP ...
Sander, Simon
core  

Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity

, 2009
TRPM2 is a Ca2+-permeable nonselective cation channel that plays important roles in oxidative stress-mediated cell death and inflammation processes. However, how TRPM2 is regulated under physiological and pathological conditions is not fully understood ...
Jia Xie, Lixia Yue, Yue, Lixia, Jianyang Du, Du, Jianyang, Xie, Jia   +5 more
core   +1 more source

Investigation Into the Pathogenesis of Type 2 Cardiorenal Syndrome via the ROS–TRPM2 Signaling Axis

Frontiers in Bioscience-Landmark
Background: Type 2 cardiorenal syndrome (CRS) is a complex disease characterized by the interplay between the heart and kidneys. The pathophysiology of type 2 CRS involves multiple molecular signaling pathways.
Yanxia Li, Fengrong Wang
doaj   +1 more source

Another TRP to endothelial dysfunction [PDF]

, 2008
Gudermann, Thomas, Dietrich, Alexander
core   +1 more source