TRPM2 enhances ischemic excitotoxicity by associating with PKCγ [PDF]
Cell ReportsSummary: N-methyl-D-aspartate receptor (NMDAR)-mediated glutamate excitotoxicity significantly contributes to ischemic neuronal death and post-recanalization infarction expansion.
Pengyu Zong +9 more
doaj +2 more sources
TRPM2 exacerbates airway inflammation by regulating oxidized-CaMKⅡ in allergic asthma
HeliyonBackground: Airway epithelial cells play important roles in allergic asthma. Transient receptor potential melastatin-related 2 (TRPM2) and oxidized Ca2+/calmodulin-dependent protein kinase Ⅱ (ox-CaMKⅡ) participate in the airway inflammation.
Xueping Liu +3 more
doaj +2 more sources
Cell DivisionOvarian cancer (OC) becomes a fatal gynecologic malignant cancer in females worldwide. Target therapy is a promising therapeutical choice for patients with OC, and identifying biomarkers and exploring molecular mechanisms are necessary.
Wei Zhu, Shiqin Mao, Juan Jiang
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Alteration in Intracellular Zn2+ Homeostasis as a Result of TRPM2 Channel Activation Contributes to ROS-Induced Hippocampal Neuronal Death [PDF]
Frontiers in Molecular Neuroscience, 2017 Transient receptor potential melastatin-related 2 (TRPM2) channel, a molecular sensor for reactive oxygen species (ROS), plays an important role in cognitive dysfunction associated with post-ischemia brain damage thought to result from ROS-induced TRPM2 ...
Xin Li +4 more
doaj +3 more sources
Neuroimmune Regulation by TRPM2 Channels
CellsMutual interaction between the nervous and immune systems underpins many pathophysiological processes. Transient Receptor Potential Melastatin 2 (TRPM2) channels are abundantly expressed in both systems, acting as a critical interface of neuroimmune ...
Xuming Zhang, Mitali Malhotra
doaj +2 more sources
Journal of Pharmacological Sciences, 2017 Purpose: TRPM2 is a Ca2+-permeable channel that is activated by H2O2. TRPM2-mediated Ca2+ signaling has been implicated in the aggravation of inflammatory diseases.
Shinichiro Yamamoto +4 more
doaj +2 more sources
Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation [PDF]
eLife, 2018 Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable cation channel required for immune cell activation, insulin secretion, and body heat control.
Zhe Zhang +4 more
doaj +2 more sources
TRPM2 overactivation drives hyperlipidemia-induced dysfunction of myeloid cells and neurovascular units [PDF]
Cell Reports MedicineSummary: Hyperlipidemia induces cellular dysfunction and is strongly linked to various diseases. The transient receptor potential channel melastatin 2 (TRPM2) plays a critical role in endothelial injury, immune cell activation, and neuronal death.
Pengyu Zong +14 more
doaj +2 more sources
Crosstalk Between Vascular Redox and Calcium Signaling in Hypertension Involves TRPM2 (Transient Receptor Potential Melastatin 2) Cation Channel [PDF]
, 2020 Increased generation of reactive oxygen species (ROS) and altered Ca2+ handling cause vascular damage in hypertension. Mechanisms linking these systems are unclear, but TRPM2 (transient receptor potential melastatin 2) could be important because TRPM2 is
Karla B. Neves +6 more
core +2 more sources
TRPM2 Channel-Mediated Signalling Mechanisms for Neuronal Cell Death [PDF]
, 2017 Transient receptor potential melastatin-related 2 (TRPM2) channel is gated by ADP-ribose (ADPR) and potently activated by reactive oxygen species (ROS) through stimulating ADPR-generating mechanisms. Recent studies provide evidence to show a crucial role
Li, Xin
core +5 more sources