Results 11 to 20 of about 1,608 (146)
Identification of Ligands for Ion Channels: TRPM2
ChemBioChemAbstractTransient receptor potential melastatin 2 (TRPM2) is a calcium‐permeable, nonselective cation channel with a widespread distribution throughout the body. It is involved in many pathological and physiological processes, making it a potential therapeutic target for various diseases, including Alzheimer's disease, Parkinson's disease, and cancers.
Yushu Gu +3 more
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TRPM2 promotes pancreatic cancer by PKC/MAPK pathway
Cell Death and Disease, 2021 The mechanism of pancreatic cancer (PA) is not fully understanded. In our last report, TRPM2 plays a promising role in pancreatic cancer. However, the mechanism of TRPM2 is still unknown in this dismal disease.
Rui Lin +7 more
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The Role of TRPM2 in Endothelial Function and Dysfunction
International Journal of Molecular Sciences, 2021 The transient receptor potential (TRP) melastatin-like subfamily member 2 (TRPM2) is a non-selective calcium-permeable cation channel. It is expressed by many mammalian tissues, including bone marrow, spleen, lungs, heart, liver, neutrophils, and endothelial cells.
Wioletta Zielińska +3 more
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Cell DivisionOvarian cancer (OC) becomes a fatal gynecologic malignant cancer in females worldwide. Target therapy is a promising therapeutical choice for patients with OC, and identifying biomarkers and exploring molecular mechanisms are necessary.
Wei Zhu, Shiqin Mao, Juan Jiang
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Function and modulation of TRPM2 channels [PDF]
, 2013 Melastatin-related transient receptor potential 2 (TRPM2) channel is a Ca2+-permeable cation channel that is gated by ADP-ribose (ADPR) and also activated by reactive oxygen species (ROS) such as H2O2. TRPM2 channel are shown to be critically involved in
Zou, Jie
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Research, 2023 Hepatic ischemia–reperfusion (IR) injury is a serious clinical problem that complicates liver resection and transplantation. Despite recent advances in understanding of the pathophysiology of hepatic IR injury, effective interventions and therapeutics ...
Cheng Zhong +16 more
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TRPM2-AS promotes the malignancy of osteosarcoma cells by targeting miR-15b-5p/PPM1D axis
, 2022 Osteosarcoma (OS) is a malignant tumor with a low survival rate and a high incidence rate worldwide. Although research has reported the involvement of long non-coding RNAs (lncRNAs) in the pathogenesis of OS cells, the role of TRPM2-AS, miR-15b-5p, and ...
Yingchun Cai (3809575) +4 more
core +1 more source
Scientific Reports, 2022 Transient receptor potential channel TRPM2 is highly expressed in many cancers and involved in regulation of key physiological processes including mitochondrial function, bioenergetics, and oxidative stress.
Lei Bao +6 more
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TRPM2: bridging calcium and ROS signaling pathways—implications for human diseases
Frontiers in Physiology, 2023 TRPM2 is a versatile and essential signaling molecule that plays diverse roles in Ca2+ homeostasis and oxidative stress signaling, with implications in various diseases. Research evidence has shown that TRPM2 is a promising therapeutic target.
Maria Maliougina, Yassine El Hiani
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TRPM2: Shredding the mitochondrial network [PDF]
Channels, 2017 Mitochondria, traditionally known for their role in power (ATP) generation, are important signalling organelles.
Li, F, Abuarab, N, Sivaprasadarao, A
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