Results 41 to 50 of about 709 (136)
Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.
PLoS ONE, 2016 Members of the TRP superfamily of ion channels mediate mechanosensation in some organisms, and have been suggested as candidates for the mechanotransduction channel in vertebrate hair cells.
Xudong Wu +8 more
doaj +1 more source
MCOLN1/TRPML1-MCOLN3/TRPML3 heteromer and its coupling to Ca<sup>2+</sup> sensor SYT5 regulates autophagosome-lysosome fusion in a PtdIns4P-dependent manner. [PDF]
AutophagyMacroautophagy/autophagy progresses through Ca2+-dependent multiple fusion events. Recently, we reported that the intracellular Ca2+ channel MCOLN3/TRPML3 provides Ca2+ for membrane fusion during autophagosome formation as a downstream effector of phosphatidylinositol-3-phosphate (PtdIns3P).
Kwon J +6 more
europepmc +3 more sources
Single channel recordings of TRPV5, TRPML3, and TRPML3/TRPV5 currents.
, 2013 Shown are representative single-channel traces, as well as amplitude and open dwell-time histograms for TRPV5 (A), TRPML3 (B), and the two varieties of traces observed for TRPML3/TRPV5 (C,D) under conditions 1, 2, and 3 at −150 mV. Solid lines and dotted
Anthony J. Ricci (212303) +4 more
core +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source
Stoichiometric analyses of TRPML3/TRPV5 currents.
, 2013 (A–D) Traces show currents at −150 mV recorded from HEK293 cells expressing TRPV5/TRPML3, in the presence of extracellular solutions containing 140 mM Na+ (condition 1, black), 150 mM K+ (condition 2, red), 140 mM Na+, 0.1 mM EGTA (condition 3, blue ...
Anthony J. Ricci (212303) +4 more
core +1 more source
RNF13 mediates pH- and Ca2+-dependent regulation of lysosomal positioning
Cell ReportsSummary: Environmental factors such as extracellular pH (pHe) and nutrition status affect lysosomal localization and autophagy, but how pHe, intracellular pH (pHi), and Ca2+ regulate lysosome transport is not well understood. Here, we identify RNF13 as a
Lan Thi Trinh +9 more
doaj +1 more source
Journal of Cellular Physiology, Volume 240, Issue 2, February 2025.ABSTRACT Transmembrane protein 175 (TMEM175) is an endolysosomal cation channel, which has attracted much attention recently from academics and the pharmaceutical industry alike since human mutations in TMEM175 were found to be associated with the development of Parkinson's disease (PD).
Tobias Schulze +5 more
wiley +1 more source
S‐acylation of Ca2+ transport proteins in cancer
Chronic Diseases and Translational Medicine, Volume 10, Issue 4, Page 263-280, December 2024.The implication of Ca2+ transport proteins in cancer has been previously documented in several studies recently reviewed. Transporters highlighted in red have been biochemically documented to be S‐acylated. Abstract Alterations in cellular calcium (Ca2+) signals have been causally associated with the development and progression of human cancers ...
Sana Kouba, Nicolas Demaurex
wiley +1 more source
Molecular and functional assessment of mutant TRPML3(Δ exon11) channels.
, 2013 A, Shown are representative cells expressing the respective murine (m) constructs of wild-type TRPML3 or mutant TRPML3(Δ exon11), C-terminally fused to yellow fluorescent protein, 24 h after transfection. Scale bar = 10 µm.
Lars Becker (358879) +3 more
core +1 more source
Cancer Reports, Volume 7, Issue 6, June 2024.Abstract Background Pancreatic adenocarcinoma (PAAD), a member of highly lethal malignant tumors, has a poor outcome and extremely poor prognosis. The transient receptor potential (TRP) superfamily, a group of nonselective cation channels, is capable of influencing cellular functions by regulating calcium homeostasis.
Sen Qiao, Fengming Wu, Hongmei Wang
wiley +1 more source