Results 51 to 60 of about 709 (136)
Transient receptor potential mucolipin 1 circumvents oxidative stress in primary human melanocytes
Skin Research and Technology, Volume 30, Issue 6, June 2024.Abstract Background Transient Receptor Potential Mucolipin 1 (TRPML1) serves as a pivotal reactive oxygen species (ROS) sensor in cells, which is implicated in the regulation of autophagy. However, its function in melanocyte autophagy under oxidative stress remains elusive.
Yi Chen +7 more
wiley +1 more source
Coordinating activation of endo‐lysosomal two‐pore channels and TRP mucolipins
The Journal of Physiology, Volume 602, Issue 8, Page 1623-1636, 15 April 2024.Abstract figure legend Schematic depicting flux through a lysosomal ion channel in response to two agonists applied singly (left and right) and synergistic activation upon combined stimulation (centre). Abstract Two‐pore channels and TRP mucolipins are ubiquitous endo‐lysosomal cation channels of pathophysiological relevance.
Yu Yuan +5 more
wiley +1 more source
Endolysosomal cation channels and toxic chronic lung disease [PDF]
, 2022 Chronic obstructive pulmonary disease (COPD) is a prevalent disease that affects million people worldwide. Classified as the third most common cause of death globally, it accounts for more than 3 million deaths per year. Smoking constitutes the main risk
Spix, Barbara Julia
core +1 more source
Effects of dominant-negative and inactive isoforms of TRPML3 and TRPV5.
, 2013 (A) Representative whole cell currents shown were obtained from cells coexpressing TRPML3D458K and TRPV5 (ML3D458K/ V5), TRPV5D535K and TRPV5 (V5D535K/ V5), TRPML3 and TRPV5D535K (ML3/V5D535K), TRPV5D550K and TRPV5 (V5D550K/ V5), and TRPML3 and ...
Anthony J. Ricci (212303) +4 more
core +1 more source
ENDOLYSOSOMAL TRPML3 / BK COMPLEX IN AUTOPHAGY INDUCTION AND PATHOGEN DEFENSE
We found the TRPML3/BK feedback loop is important for efficient autophagy induction during nutrient deprivation or bacterial infection.The transient receptor potential mucolipin 3 (TRPML3), encoded by the MCOLN3 gene, functions as a calcium (Ca² ...
Xu, Mengnan
core +2 more sources
Pharmacological properties of HEK293 cells expressing TRPV5, TRPML3, and both proteins.
, 2013 (A–C) Representative traces shown from transfected HEK293 cells expressing TRPV5, TRPML3, and TRPV5/TRPML3 in response to step polarization (from 0 mV to –150 mV) before (black lines) and after 1 mM dihydrostreptomycin (DHSM) (green lines), 100 µM ...
Anthony J. Ricci (212303) +4 more
core +1 more source
Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
, 2013 (A) Traces show representative currents obtained from non-transfected HEK293 cells, and cells expressing TRPV5, TRPML3, and TRPV5/TRPML3, in the presence of extracellular solutions starting with 140 mM Na+ (condition 1, black), and successively switched ...
Anthony J. Ricci (212303) +4 more
core +1 more source
Targeting strategy for disruption of the Trpml3 gene.
, 2013 A, Transmembrane-spanning domains are depicted as grey bars and numbered from 1–6. The orange frame indicates the part of the TRPML3 protein that is encoded by exon 11, which will be deleted (pore loop and TM6).
Lars Becker (358879) +3 more
core +1 more source
, 2014 Ultrastructural examination of ileum from (A–C) control Trpml3−/− and (D–F) Trpml3−/−;Trpml1−/− littermates at P5. By this stage, ileal enterocytes of control Trpml3−/− pups contain their characteristic giant lysosome (GL), which is partially filled with
Natalie N. Remis (676650) +5 more
core +1 more source