Results 61 to 70 of about 709 (136)
EXPLORING THE ROLES OF TRPML3 IN TNBC PROLIFERATION, MIGRATION, AND BIOENERGETICS [PDF]
In this study, we show that TRPML3 knockdown (ML3KD) reduces TNBC proliferation, induces G2/M cell cycle arrest and promotes apoptosis. In addition, ML3KD reduces TNBC migration and invasion ability.
De Abreu Gomes, Gabriela Maria
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TRPML3 distribution in thymus.
, 2022 (A) Shown is an overview image of one lobe of the thymus. (B) Image of CD8 alpha stained whole thymus tissue, revealing regions of cytotoxic T-cells mainly in outer regions within the thymus. C, cortex. M, medulla.
Ulrich Boehm (180339) +10 more
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, 2014 (A,B) H&E staining of distal ileum from embryos at 18.5 days post coitum (E18.5) reveals slight vacuolation in some illeal enterocytes of (A) Trpml3−/−;Trpml1−/− mice, but not of (B) Trpml3−/− mice. (C–J) H&E staining of (C,E,G,I) distal ileum and (D,F,H,
Natalie N. Remis (676650) +5 more
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Generation of mice with knockout alleles of Trpml3.
, 2014 (A) Schematic representation of targeting construct and Wild type, Targeted (Flox-Neo), Floxed and Knockout alleles of Trpml3. The Mouse Genomics Informatics (MGI) name assigned to the KO allele is Mcoln3tm1.1Jga.
Natalie N. Remis (676650) +5 more
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Reduced endocytotic rate in P7 neonates lacking mucolipins 3 and 1.
, 2014 (A–B) Confocal images of enterocytes from P7 littermates fed Texas Red-Dextran 120 minutes prior to tissue collection. There is an accumulation of dextran in Trpml3−/− enterocytes (A) whereas there is minimal dextran accumulation in Trpml3−/−;Trpml1 ...
Natalie N. Remis (676650) +5 more
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Functional multimerization of mucolipin channel proteins [PDF]
, 2010 MCOLN1 encodes mucolipin-1 (TRPML1), a member of the transient receptor potential TRPML subfamily of channel proteins. Mutations in MCOLN1 cause mucolipidosis-type IV (MLIV), a lysosomal storage disorder characterized by severe neurologic, ophthalmologic,
Zhang, Peng +6 more
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, 2013 A, Graph shows representative ABR waveforms of 3-week-old HprtCre/+; Trpml3+/+ and HprtCre/+; Trpml3 Δ/Δ mice in response to a click stimulus. ABRs were recorded at sound stimulation intensities of 25–70 dB.
Lars Becker (358879) +3 more
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, 2013 A, Schematic drawing of the Trpml3 targeted allele before (Trpml3lox/) and after Cre recombination (Trpml3 Δ/). The positions of sense (sn) and antisense (asn) oligonucleotides are indicated with arrows.
Lars Becker (358879) +3 more
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Targeting Sequence and Function-Dependence of Subcellular Localization of Transient Receptor Potential Mucolipin Channels and Characterization of Engineered Molecule Probes For Detecting Lysosomal Calcium Release [PDF]
, 2014 Both TRPML1 and TRPML3 are members of the mucolipin subfamily of Transient Receptor Potential (TRP) channels. They have been implicated in endolysosomal functions such as divalent cation release, luminal pH regulation, autophagy and vesicle trafficking ...
Xiong, Jian
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Failure to thrive of suckling mice lacking mucolipins 3 and 1.
, 2014 (A–D) Trpml3−/−;Trpml1−/− pups, denoted by asterisks, shown next to their Trpml3−/− control littermates. (A) A litter at P8, in which the three smallest pups have the Trpml3−/−;Trpml1−/− genotype. (B) Ventral view of a pair of littermates at P7, of which
Natalie N. Remis (676650) +5 more
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