Results 71 to 80 of about 709 (136)

Pathological vacuolation of neonatal, but not adult, enterocytes lacking both mucolipins 3 and 1, but not either mucolipin alone.

, 2014
(A–D) Hematoxylin and eosin (H&E) staining of paraffin-embedded sections of intestine reveals abnormal vacuolation in (A) Trpml3−/−;Trpml1−/− pups, but not in (C) wild type, (B) Trpml3−/− or (D) Trpml1−/− pups.
Natalie N. Remis (676650), Teerawat Wiwatpanit (676651), Jorge A. Cantú (676654), Andrew J. Castiglioni (676652), Jaime García-Añoveros (676655), Emma N. Flores (676653)   +5 more
core   +1 more source

The pathological vacuoles of suckling enterocytes lacking mucolipins 1 and 3 are aberrant hybrid organelles with endosomal and lysosomal components.

, 2014
Cryosections of intestines from 3 hour old (A–C) control Trpml3−/− and (D–F) Trpml3−/−;Trpml1−/− littermates that had been fed formula with Texad Red-dextran immediately after birth.
Natalie N. Remis (676650), Teerawat Wiwatpanit (676651), Jorge A. Cantú (676654), Andrew J. Castiglioni (676652), Jaime García-Añoveros (676655), Emma N. Flores (676653)   +5 more
core   +1 more source

Formation of pathological vacuolar organelles in neonatal enterocytes lacking both mucolipins 1 and 3.

, 2014
Ultrastructural examination of ileum from (A) control Trpml3−/− and (B–H) Trpml3−/−;Trpml1−/− pups at P0. The intestinal epithelia of Trpml3−/−;Trpml1−/− mice contain normal appearing goblet cells (GC) and enterocyte nuclei (N). Their enterocytes display
Natalie N. Remis (676650), Teerawat Wiwatpanit (676651), Jorge A. Cantú (676654), Andrew J. Castiglioni (676652), Jaime García-Añoveros (676655), Emma N. Flores (676653)   +5 more
core   +1 more source

Rotarod experiments.

, 2013
The average latencies to fall ± SEM (in sec) are shown for 3-month-old HprtCre/+;Trpml3+/+ (n = 8) and HprtCre/+;Trpml3 Δ/Δ (n = 8) mice. The experiment was executed over a time range of 6 days.
Lars Becker (358879), Simone Jörs (358878), Stefan Heller (36641), Christian Grimm (84987)   +3 more
core   +1 more source

Structures of the Endolysosomal TRPML3 Channel in Distinct States Reveal Activation and Regulation Mechanisms [PDF]

Biophysical Journal, 2018
Minghui Li, Xiaoyuan Zhou, Deyuan Su, Qi Jia, Huan Li, Xueming Li, Jian Yang   +6 more
openaire   +1 more source

Differential regulation of TRP channels in a rat model of neuropathic pain

, 2009
Neuropathic pain is a chronic disease resulting from dysfunction of the nervous system often due to peripheral nerve injury. Hypersensitivity to sensory Stimuli (mechanical, thermal or chemical) is a common source of pain in patients and ion channels ...
Oerther, S,, ERNFORS, Patrik, STAAF, Susanne, OERTHER, Sandra, Ernfors, P,, LUCAS, Guilherme, MATTSSON, Jan P., Lucas, G, Staaf, S, Mattsson, JP   +9 more
core   +1 more source

Interaction between TRPML channels and TRPV5/6.

, 2013
(A) Phylogenetic tree, based on full length sequence comparisons of human TRP channel proteins. (B) Phylogenetic tree, based on sequence comparisons of the pore forming domains of human TRP channel proteins.
Anthony J. Ricci (212303), Lars Becker (358879), Zhaohua Guo (383295), Stefan Heller (36641), Christian Grimm (84987)   +4 more
core   +1 more source

Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis. [PDF]

Korean J Physiol Pharmacol, 2023
Jung Y, Kim W, Shin NK, Bae YM, Wie J.
europepmc   +1 more source

MicroRNA-601 Enhances Osimertinib Sensitivity by Targeting Transient Receptor Potential Mucolipin 3 in Non-small Cell Lung Cancer Cells. [PDF]

J Cancer Prev
Kim MS, Kim MS.
europepmc   +1 more source

Differential ion selectivity and disease-associated dysfunction of TRPML channels revealed by patient and engineered mutants. [PDF]

J Biol Chem
Rue BE, Dischler AM, Salvagio LA, Zhu M, Xu G, Flores PC, Donovan CL, Liu X, Minckley TF, Agulnek B, Qin Y.   +10 more
europepmc   +1 more source