Results 31 to 40 of about 709 (136)
Cells, 2020 Insulin secretion from the β-cells of the islets of Langerhans is triggered mainly by nutrients such as glucose, and incretin hormones such as glucagon-like peptide-1 (GLP-1).
Md. Shahidul Islam
doaj +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels
British Journal of Pharmacology, Volume 178, Issue S1, Page S157-S245, October 2021., 2021 The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander +57 more
wiley +1 more source
Molecular Signatures of Human Chronic Atrial Fibrillation in Primary Mitral Regurgitation
Cardiovascular Therapeutics, Volume 2021, Issue 1, 2021., 2021 Objectives. Transcriptomics of atrial fibrillation (AFib) in the setting of chronic primary mitral regurgitation (MR) remains to be characterized. We aimed to compare the gene expression profiles of patients with degenerative MR in AFib and sinus rhythm (SR) for a clearer picture of AFib pathophysiology. Methods.
Günseli Çubukçuoğlu Deniz +6 more
wiley +1 more source
Frontiers in Immunology, 2020 The TRPML channels (TRPML1, TRPML2, and TRPML3), belonging to the mucolipin TRP subfamily, primary localize to a population of membrane-bonded vesicles along the endocytosis, and exocytosis pathways.
Giorgio Santoni +6 more
doaj +1 more source
Alveolar macrophages of neonatal and adult express TRPML3.
, 2022 Immunofluorescence images using F4/80 antibody as macrophage marker (A) in 10 μM lung cryosections or (B) on cells isolated by bronchoalveolar lavage. Images clearly show co-localization of τGFP and F4/80 confirming TRPML3 expression in lung macrophages.
Ulrich Boehm (180339) +10 more
core +1 more source
Biochemical and Biophysical Research Communications, 2022 Lysosomes are emerging as versatile signaling hubs that mediate numerous cellular processes, including the development of drug resistance in cancer cells. Transient receptor potential mucolipin 3 (TRPML3), an endolysosomal Ca2+-permeable channel, is implicated in regulating lysosomal trafficking during endocytosis and autophagy.
Mi Seong Kim +2 more
openaire +2 more sources
Discovery of lipophilic two‐pore channel agonists
The FEBS Journal, Volume 287, Issue 24, Page 5284-5293, December 2020., 2020 The intracellular two‐pore channels (TPCs), residing on endosomes and lysosomes, are increasingly being implicated in physiology and pathophysiology. The development of TPC activators has lagged behind, for example, the development of TRPML agonists. Recently, two independent papers described the discovery of distinct TPC agonists, for example, the PI ...
Susanne Gerndt +4 more
wiley +1 more source
Funktionelle und pharmakologische Charakterisierung des TRP-Kationenkanals TRPML3 [PDF]
, 2011 TRPML3 belongs to the mucolipin subfamily of the transient receptor potential (TRP) channels. The mouse Trpml3 gene was identified in a positional cloning project to identify the gene responsible for the varitint-waddler (Va) mouse phenotype, which ...
Jörs, Simone
core +1 more source
Principle cells of the collecting duct in neonatal and adult kidney express TRPML3.
, 2022 (A) Overview image of a longitudinal section of an adult kidney. RP, renal pelvis. RC, renal cortex. CD, collecting ducts. (B) Magnified image of the renal medulla with collecting ducts, which open into the renal pelvis.
Ulrich Boehm (180339) +10 more
core +1 more source
Journal of Extracellular Vesicles, Volume 9, Issue 1, September 2020., 2020 ABSTRACT Dendritic cells (DC) have the unique capacity to activate naïve T cells by presenting T cell receptor specific peptides from exogenously acquired antigens bound to Major Histocompatibility Complex (MHC) molecules. MHC molecules are displayed on the DC plasma membrane as well as on extracellular vesicles (EV) that are released by DC, and both ...
Marthe F. S. Lindenbergh +5 more
wiley +1 more source