Results 21 to 30 of about 709 (136)
Mucolipin co-deficiency causes accelerated endolysosomal vacuolation of enterocytes and failure-to-thrive from birth to weaning. [PDF]
PLoS Genetics, 2014 During the suckling period, intestinal enterocytes are richly endowed with endosomes and lysosomes, which they presumably utilize for the uptake and intracellular digestion of milk proteins. By weaning, mature intestinal enterocytes replace those rich in
Natalie N Remis +5 more
doaj +1 more source
TRPML3‑mediated lysosomal Ca2+ release enhances drug sequestration and biogenesis, promoting osimertinib resistance in non‑small cell lung cancer. [PDF]
Oncol RepLysosomes and lysosomal Ca2+ play crucial roles in cellular homeostasis and drug resistance. The lysosomal Ca2+ channel transient receptor potential mucolipin 3 (TRPML3; also known as mucolipin‑3 or MCOLN3) is a key regulator of autophagy and membrane trafficking; however, its role in tyrosine kinase inhibitor (TKI) resistance remains unclear.
Kim MS, Kim MS.
europepmc +3 more sources
The Ca2+ Channel TRPML3 Regulates Membrane Trafficking and Autophagy [PDF]
Traffic, 2009 TRPML3 is an inward rectifying Ca2+ channel that is regulated by extracytosolic H+. Although gain‐of‐function mutation in TRPML3 causes the varitint‐waddler phenotype, the role of TRPML3 in cellular physiology is not known. In this study, we report that TRPML3 is a prominent regulator of endocytosis, membrane trafficking and autophagy.
Hyun Jin, Kim +4 more
openaire +2 more sources
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels
British Journal of Pharmacology, Volume 180, Issue S2, Page S145-S222, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander +72 more
wiley +1 more source
The Journal of Physiology, Volume 601, Issue 14, Page 2935-2958, 15 July 2023., 2023 Abstract figure legend Amphipathic weak bases like CatSper blockers (B) diffuse across the sperm plasma membrane from a region of high concentration to one of low concentration (1). Inside the cell, these compounds are accumulated and protonated (BH+) into the acrosomal lumen (2).
Enrique I. Oliver +3 more
wiley +1 more source
Molecular Nutrition &Food Research, Volume 67, Issue 4, February 2023., 2023 This study investigates the impact of a pungent compound from ginger, [6]‐gingerol, on the immune responses of a specific human blood leukocyte cell type, the neutrophils. The study observes that [6]‐gingerol facilitates the production of reactive oxygen species and the secretion of a chemokine (CXCL8) upon subsequent stimulation with a bacterial ...
Gaby Andersen +3 more
wiley +1 more source
Skin melanocytes express TRPML3.
, 2022 (A) Images showing sections of the back skin. τGFP expression is visible in hair follicles (HF). (B) Trpml3 levels in back skin correlate with initial synchrony of the hair follicle growth cycle. Follicle growth phases (anagen I, P9; anagen II, P27) show
Ulrich Boehm (180339) +10 more
core +1 more source
Effective chiral pool synthesis of both enantiomers of the TRPML inhibitor trans‐ML‐SI3
Archiv der Pharmazie, Volume 355, Issue 2, February 2022., 2022 An effective chiral pool synthesis of both enantiomers of the TRPML inhibitor trans‐ML‐SI3 was worked out on two different routes, both starting from enantiomerically pure cis‐2‐aminocyclohexanols. The absolute configuration of the more active enantiomer was elucidated. These chiral pool syntheses provide sufficient amounts of the enantiomerically pure
Katharina Kriegler +3 more
wiley +1 more source
A TRP Family Based Signature for Prognosis Prediction in Head and Neck Squamous Cell Carcinoma
Journal of Oncology, Volume 2022, Issue 1, 2022., 2022 Purpose. Head and neck squamous cell carcinoma (HNSCC) is a classical type of head and neck cancers, with heterogeneous clinical outcome. This project is set out to create a robust risk signature based on TRP family genes (TFGs) for prognosis evaluation in HNSCC. Methods.
Fangfang Pan +6 more
wiley +1 more source
Distribution of Trpml3 mRNA in major adult organs.
, 2022 (A)Trpml3 levels detected by RT-qPCR using primers in exon 8 and exon 9 of Trpml3, normalized to 18S rRNA, and displayed (in parentheses) relative to normalized Trpml3 levels in vomeronasal organ (VNO).
Ulrich Boehm (180339) +10 more
core +1 more source