Results 1 to 10 of about 3,136 (126)

BRET‐Based Approaches for Ion Channels: Emerging Applications and Future Directions [PDF]

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Nadine Kock, Laura Heitzer, Joana Massa, Marvin Taterra, Marcel Bermúdez, Oliver Koch, Matthias Schiedel   +6 more
wiley   +2 more sources

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment [PDF]

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +2 more sources

HIV-1 gp120-induced lysosomal stress responses are controlled by TRPML1 redox sensors [PDF]

Redox Report
Background Increased lysosomal stress responses (LSR) are commonly implicated in the pathogenesis of neurodegenerative disorders including HIV-1-associated neurocognitive disorders (HAND).
Nirmal Kumar, Braelyn Liang, Jonathan D. Geiger   +2 more
doaj   +2 more sources

TRPML1—Emerging Roles in Cancer

Cells, 2020
The mucolipin-1 (TRPML1) channel maintains lysosomal ionic homeostasis and regulates autophagic flux. Defects of TRPML1 lead to lysosomal storage diseases and neurodegeneration.
Yassine El Hiani
exaly   +3 more sources

TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling

Cell Reports, 2019
Summary: We screen ion channels and transporters throughout the genome to identify those required by human melanoma cells but not by normal human melanocytes.
Zhiyu Zhao, Divya Bezwada, Sean Morrison   +2 more
exaly   +3 more sources

TRPML1 as a potential therapeutic target for triple-negative breast cancer: a review

Frontiers in Oncology, 2023
Triple-negative breast cancer (TNBC) is the most refractory subtype of breast cancer, and effective treatments are urgently needed owing to its poor prognosis.
Ying Pan, Qiancheng Zhao, Haitao He, Yubo Qi, Yujie Bai, Jia Zhao, Yiming Yang   +6 more
exaly   +3 more sources

TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition [PDF]

The EMBO Journal
In pulmonary fibrosis lung tissue is thickened and scarred, and the lungs become progressively stiffer and smaller, leading to low levels of blood oxygen and shortness of breath. Lung fibrosis is not curable and life expectancy is reduced.
Eva-Maria Weiden, Zala Serianz, Yvonne Klingl, Simone Jörs, Dawid Jaślan, Marco Keller, Sandra Prat Castro, Mane Mkhitaryan, Aicha Jeridi, Daria Briukhovetska, Barbara Spix, Anna Scotto Rosato, Ahmed Agami, Herbert B Schiller, Suhasini Rajan, Johann Schredelseker, Giorgio Fois, Manfred Frick, Sebastian Kobold, Margarethe Klein, Fabian Geisler, Jorge Garcia-Fortanet, Leon O Murphy, Franz Bracher, Christian Wahl-Schott, Thomas Gudermann, Alexander Dietrich, Martin Biel, Ali Önder Yildirim, Christian Grimm   +29 more
doaj   +2 more sources

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions [PDF]

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +2 more sources

PRELID1 and VDAC3 Coordinate a Senescence‐Like State in Germinal Center B Cells to Promote IL‐7–Driven Antitumor Immunity in Colorectal Cancer [PDF]

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Colorectal cancer is characterized by an immunosuppressive microenvironment that limits immunotherapy efficacy. We identify a senescence‐like state in germinal center B cells driven by the PRELID1–VDAC3 axis, which promotes IL‐7 secretion, alleviates CD8+ T‐cell exhaustion, and enhances antitumor immunity. Targeting this pathway improves responsiveness
Yuhan Liao, Huimeng Xu, Xinghua Zhuo, Shupeng Hu, Lanhui Huang, Zhe Hao, Jianxiong Chen, Yulu Wang, Jun Zhou   +8 more
wiley   +2 more sources

TRPML1 agonists synergize with enzyme replacement therapy in fibroblasts from Pompe disease patients [PDF]

Journal of Translational Medicine
Objective Pompe disease is a severe and progressive metabolic myopathy caused by pathogenic variants of the GAA gene, deficiency of acid alpha-glucosidase (GAA), and lysosomal glycogen storage.
Carla Damiano, Antonietta Tarallo, Sandra Strollo, Nadia Minopoli, Anna Valanzano, Antonia Assunto, Maria Rosaria Tuzzi, Nicola Brunetti-Pierri, Andrea Ballabio, Nicolina Cristina Sorrentino, Giancarlo Parenti   +10 more
doaj   +2 more sources