Results 11 to 20 of about 3,697 (189)
TRPML1 gating modulation by allosteric mutations and lipids
eLifeTransient Receptor Potential Mucolipin 1 (TRPML1) is a lysosomal cation channel whose loss-of-function mutations directly cause the lysosomal storage disorder mucolipidosis type IV (MLIV).
Ninghai Gan +3 more
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Biochemical Society Transactions, 2015 TRPML1 is a ubiquitously expressed cation channel found on lysosomes and late endosomes. Mutations in TRPML1 cause mucolipidosis type IV and it has been implicated in Alzheimer's disease and HIV. However, the mechanisms by which TRPML1 activity is regulated are not well understood.
Helen, Waller-Evans, Emyr, Lloyd-Evans
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Systematic screens for proteins that interact with the mucolipidosis type IV protein TRPML1. [PDF]
PLoS ONE, 2013 Mucolipidosis type IV is a lysosomal storage disorder resulting from mutations in the MCOLN1 gene, which encodes the endosomal/lysosomal Transient Receptor Potential channel protein mucolipin-1/TRPML1.
Ellen Spooner +8 more
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Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors [PDF]
Scientific Reports, 2021 The cation channel TRPML1 is an important regulator of lysosomal function and autophagy. Loss of TRPML1 is associated with neurodegeneration and lysosomal storage disease, while temporary inhibition of this ion channel has been proposed to be beneficial ...
Philipp Rühl +12 more
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Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells
Journal of Cell Science, 2022 ABSTRACTLiver cancers, including hepatocellular carcinoma (HCC), are the second leading cause of cancer death worldwide, and novel therapeutic strategies are still highly needed. Recently, the endolysosomal cation channel TRPML1 (also known as MCOLN1) has gained focus in cancer research because it represents an interesting novel target. We utilized the
Wei Xiong Siow +13 more
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Protein & Cell, 2017 TRPML1 channel is a non-selective group-2 transient receptor potential (TRP) channel with Ca2+ permeability. Located mainly in late endosome and lysosome of all mammalian cell types, TRPML1 is indispensable in the processes of endocytosis, membrane ...
Sensen Zhang +4 more
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LAMTOR1 regulates dendritic lysosomal positioning in hippocampal neurons through TRPML1 inhibition [PDF]
Frontiers in Cellular NeuroscienceIntracellular lysosomal trafficking and positioning are fundamental cellular processes critical for proper neuronal function. Among the diverse array of proteins involved in regulating lysosomal positioning, the Transient Receptor Potential Mucolipin 1 ...
Jiandong Sun +4 more
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Structural and Functional Studies of TRPML1 and TRPP2 [PDF]
, 2017 In recent years, the determination of several high-resolution structures of transient receptor potential (TRP) channels has led to significant progress within this field. The primary focus of this dissertation is to elucidate the structural characterization of TRPML1 and TRPP2.
Benvin, Nicole Marie
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Cellular Physiology and Biochemistry, 2017 Background: TRPML1 is reported to be involved in the pathogenesis of Alzheimer’s disease (AD) by regulating autophagy; however, the underlying mechanism is not completely clear.
Lu Zhang +6 more
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Ecotoxicology and Environmental Safety, 2023 Fluoride is capable of inducing developmental neurotoxicity; regrettably, the mechanism is obscure. We aimed to probe the role of lysosomal biogenesis disorder in developmental fluoride neurotoxicity—specifically, the regulating effect of the transient ...
Jingjing Zhang +7 more
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