Results 21 to 30 of about 3,697 (189)
Regulation of Ferroptosis Sensitivity in Hepatocellular Carcinoma Cells by Lysosomal Ion Channels TPC2 and TRPML1 [PDF]
AntioxidantsFerroptosis is an iron-dependent, lipid peroxidation–driven form of regulated cell death that has emerged as a therapeutic vulnerability in hepatocellular carcinoma (HCC), yet the contribution of lysosomes to this process remains incompletely understood.
Franz Geisslinger +6 more
doaj +2 more sources
Structural basis for PtdInsP2-mediated human TRPML1 regulation [PDF]
Nature Communications, 2018 Transient receptor potential mucolipin 1 (TRPML1) is a lysosomal channel which maintains the low pH and calcium levels for lysosomal function. Here authors use structural biology and electrophysiology to show how lipids bind and allosterically activate ...
Michael Fine +2 more
doaj +3 more sources
TRPML1: The Ca(2+)retaker of the lysosome
Cell Calcium, 2018 Efficient functioning of lysosome is necessary to ensure the correct performance of a variety of intracellular processes such as degradation of cargoes coming from the endocytic and autophagic pathways, recycling of organelles, and signaling mechanisms involved in cellular adaptation to nutrient availability.
Di Paola, Simone +2 more
openaire +4 more sources
Coexpression of TRPML1 and TRPML2 Mucolipin Channels Affects the Survival of Glioblastoma Patients [PDF]
International Journal of Molecular Sciences, 2022 Among brain cancers, glioblastoma (GBM) is the most malignant glioma with an extremely poor prognosis. It is characterized by high cell heterogeneity, which can be linked to its high malignancy. We have previously demonstrated that TRPML1 channels affect the OS of GBM patients.
Giorgio Santoni +7 more
openaire +4 more sources
CellsBackground: The lysosome has emerged as a promising target for overcoming chemoresistance, owing to its role in facilitating the lysosomal sequestration of drugs.
Yongsang Song, Untack Cho, Boyun Kim
exaly +3 more sources
Aza Analogs of the TRPML1 Inhibitor Estradiol Methyl Ether (EDME)
Molecules, 2023 Estradiol methyl ether (EDME) has recently been described by us as a very potent and subtype-specific inhibitor of the lysosomal cation channel TRPML1.
Philipp Rühl, Franz Bracher
doaj +3 more sources
Regulation of TRPML1 by Lipids in Lysosomes. [PDF]
, 2012 TRPML1 is an inwardly-rectifying Ca2+-permeable channel in late endosomes and lysosomes (LELs). Loss-of-function mutations on the human TRPML1 gene cause a devastating pediatric neurodegenerative disease called type IV Mucolipidosis (ML4). Although it is
Shen, Dongbiao
core +7 more sources
Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB
Cell Death and Disease, 2022 Increased brain iron content has been consistently reported in sporadic Parkinson’s disease (PD) patients, and an increase in cytosolic free iron is known to cause oxidative stress and cell death.
Belén Fernández +9 more
doaj +5 more sources
Palmitate impairs autophagic degradation via oxidative stress/perilysosomal Ca2+ overload/mTORC1 activation pathway in pancreatic β cells [PDF]
JCI InsightSaturated fatty acids impose lipotoxic stress on pancreatic β cells, leading to β cell failure and diabetes. In this study, we investigate the critical role of organellar Ca2+ disturbance on defective autophagy and β cell lipotoxicity.
Ha Thu Nguyen +13 more
doaj +2 more sources
Ecotoxicology and Environmental Safety, 2023 Aflatoxin B1 (AFB1) is a stable mycotoxin that contaminates animal feed on a large scale and causes severe damage to intestinal cells, induces inflammation and stimulates autophagy.
Xinyi Cheng +9 more
doaj +1 more source