Results 51 to 60 of about 2,132 (150)

Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels

Frontiers in Physiology, 2021
Transient receptor potential (TRP) superfamily consists of a diverse group of non-selective cation channels that has a wide tissue distribution and is involved in many physiological processes including sensory perception, secretion of hormones ...
Raiana dos Anjos Moraes, Raiana dos Anjos Moraes, R. Clinton Webb, Darízy Flávia Silva, Darízy Flávia Silva   +4 more
doaj   +1 more source

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

Signal Transduction and Targeted Therapy, 2023
Transient receptor potential (TRP) channels are sensors for a variety of cellular and environmental signals. Mammals express a total of 28 different TRP channel proteins, which can be divided into seven subfamilies based on amino acid sequence homology ...
Miao Zhang, Yueming Ma, Xianglu Ye, Ning Zhang, Lei Pan, Bing Wang   +5 more
doaj   +1 more source

Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient’s Survival [PDF]

, 2019
A link between mucolipin channels and tumors has been recently suggested. Herein, we aim to investigate the transient receptor potential mucolipin (TRPML)-1 relevance in glioblastoma.
Maria Beatrice Morelli, Consuelo Amantini, Antonella Arcella, Tomassoni, Daniele, Santoni, Giorgio, Arcella, Antonella, Amantini, Consuelo, Giorgio Santoni, Morelli, Maria Beatrice, Massimo Nabissi, Daniele Tomassoni, Nabissi, Massimo   +11 more
core   +1 more source

Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

eLife, 2018
Cytokines and chemokines are produced and secreted by a broad range of immune cells including macrophages. Remarkably, little is known about how these inflammatory mediators are released from the various immune cells.
Eva Plesch, Cheng-Chang Chen, Elisabeth Butz, Anna Scotto Rosato, Einar K Krogsaeter, Hua Yinan, Karin Bartel, Marco Keller, Dina Robaa, Daniel Teupser, Lesca M Holdt, Angelika M Vollmar, Wolfgang Sippl, Rosa Puertollano, Diego Medina, Martin Biel, Christian Wahl-Schott, Franz Bracher, Christian Grimm   +18 more
doaj   +1 more source

Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression. [PDF]

, 2016
The Transient Receptor Potential (TRP) superfamily consists of cation-selective and non-selective ion channels playing an important role both in sensory physiology and in physiopathology in several complex diseases including cancers.
Cardinali, C, Amantini, C, POLIDORI, Carlo, Mariani, Mp, Polidori, C, Oliva, Ma, Arcella, A, Santoni, A, ARCELLA, ANTONIETTA, SANTONI, Angela, Rossi, F, AMANTINI, Consuelo, CARDINALI, CLAUDIO, Tomassoni, D, MORELLI, MARIA BEATRICE, Nabissi, M, Santoni, M, NABISSI, MASSIMO, SANTONI, Giorgio, TOMASSONI, Daniele, Santoni, G.   +20 more
core   +1 more source

Characterization and expression profile of transient receptor potential channels in sea cucumber Apostichopus japonicus

Frontiers in Marine Science, 2023
BackgroundIn the past few decades, heat waves and seasonal variation linked with global warming are causing frequent fluctuations of water temperature in aquatic environments, resulting in further challenges for marine organisms.
Xuemin Wang, Yixin Wang, Yanlin Wang, Kenneth B. Storey, Muyan Chen   +4 more
doaj   +1 more source

Activated Endolysosomal Cation Channel TRPML1 Facilitates Maturation of α-Synuclein-Containing Autophagosomes

Frontiers in Cellular Neuroscience, 2022
Background: Protein aggregates are degraded via the autophagy-lysosome pathway and alterations in the lysosomal system leading to the accumulation of pathogenic proteins, including aggregates of α-synuclein in Parkinson’s disease (PD).
Maike R. Pollmanns, Judith Beer, Ines Rosignol, Ines Rosignol, Natalia Rodriguez-Muela, Natalia Rodriguez-Muela, Natalia Rodriguez-Muela, Björn H. Falkenburger, Björn H. Falkenburger, Björn H. Falkenburger, Björn H. Falkenburger, Elisabeth Dinter, Elisabeth Dinter, Elisabeth Dinter   +13 more
doaj   +1 more source

TRP Channels: Current Perspectives in the Adverse Cardiac Remodeling

Frontiers in Physiology, 2019
Calcium is an important second messenger required not only for the excitation-contraction coupling of the heart but also critical for the activation of cell signaling pathways involved in the adverse cardiac remodeling and consequently for the heart ...
Debora Falcón, Isabel Galeano-Otero, Eva Calderón-Sánchez, Eva Calderón-Sánchez, Raquel Del Toro, Raquel Del Toro, Marta Martín-Bórnez, Juan A. Rosado, Abdelkrim Hmadcha, Abdelkrim Hmadcha, Tarik Smani, Tarik Smani   +11 more
doaj   +1 more source

Functional multimerization of mucolipin channel proteins [PDF]

, 2010
MCOLN1 encodes mucolipin-1 (TRPML1), a member of the transient receptor potential TRPML subfamily of channel proteins. Mutations in MCOLN1 cause mucolipidosis-type IV (MLIV), a lysosomal storage disorder characterized by severe neurologic, ophthalmologic,
Zhang, Peng, Curcio Morelli, Cyntia, Cantiello, Horacio Fabio, Browning, Marsha F., Venugopal, Bhuvarahamurthy, Slaugenhaupt, Susan A., Charles, Florie A.   +6 more
core   +1 more source

The regulatory mechanism of mammalian TRPMLs revealed by cryo‐EM [PDF]

The FEBS Journal, 2018
Transient receptor potential mucolipin (TRPML) channels are the most recently identified subfamily of TRP channels and have seen a surge of new reports revealing both structural and functional insight. In 2017, several groups published multiple conformations of TRPML channels using cryo‐EM.
Philip, Schmiege, Michael, Fine, Xiaochun, Li   +2 more
openaire   +2 more sources