Results 71 to 80 of about 2,132 (150)
TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition
The EMBO JournalIn pulmonary fibrosis lung tissue is thickened and scarred, and the lungs become progressively stiffer and smaller, leading to low levels of blood oxygen and shortness of breath. Lung fibrosis is not curable and life expectancy is reduced.
Eva-Maria Weiden +29 more
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The role of TRP proteins in mast cells
Frontiers in Immunology, 2012 TRP proteins form cation channels that are regulated through strikingly diverse mechanisms including multiple cell surface receptors, changes in temperature, in pH and osmolarity, in cytosolic Ca2+ concentration ([Ca2+]i) and by phosphoinositides. The 28
Marc eFreichel +2 more
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STUDY OF TRPML CHANNELS REVEALS INSIGHT INTO ENDOCYTIC MALFUNCTION, ORGANELLE CROSSTALK, AND THE ACTIVATION OF PRO-APOPTOTIC PATHWAYS [PDF]
, 2012 Mucolipidosis type IV (MLIV) is a lysosomal storage disease resulting from mutations in the gene MCOLN1, which codes for a transient receptor potential family ion channel TRPML1 (Mucolipin-1). MLIV has an early onset and is characterized by developmental
Colletti, Grace
core
TRPML1 gating modulation by allosteric mutations and lipids
eLifeTransient Receptor Potential Mucolipin 1 (TRPML1) is a lysosomal cation channel whose loss-of-function mutations directly cause the lysosomal storage disorder mucolipidosis type IV (MLIV).
Ninghai Gan +3 more
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Papers of note in Nature 550 (7676)
, 2017 This week’s articles identify a mechanism that establishes the senescence-associated secretory phenotype and reveal details about the gating of TRPML channels.
Annalisa M. VanHook
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Evolutionary conservation and changes in insect TRP channels
BMC Evolutionary Biology, 2009 Background TRP (Transient Receptor Potential) channels respond to diverse stimuli and thus function as the primary integrators of varied sensory information.
Tominaga Makoto +4 more
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Mucolipidosis type IV and the mucolipins
, 2010 MLIV (mucolipidosis type IV) is a neurodegenerative lysosomal storage disorder caused by mutations in MCOLN1, a gene that encodes TRPML1 (mucolipin-1), a member of the TRPML (transient receptor potential mucolipin) cation channels.
Aviram Kogot-Levin +3 more
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Trp channel homologues in kinetoplastid parasites.
, 2013 (A) Alignment of the pore regions of human TrpML and TrpP2 channel subunits with putative homologues from kinetoplastid parasites. Sequences of the putative pore loops as well as part of the TMD5 and TMD6 regions are shown.
David L. Prole (312979) +1 more
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Vanilloid transient receptor potential cation channels: An overview [PDF]
, 2008 The mammalian branch of the Transient Receptor Potential ( TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC ('Canonical'), TRPV ('Vanilloid'), TRPM ('Melastatin'), TRPP ('Polycystin ...
Vennekens, Rudi +2 more
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TRP expression screening in DRG of CYPc rats.
, 2013 A–D, qRT-PCR analysis of Trpc (A), Trpm (B), Trpv (C), and Trpa1 and Trpml (D) mRNA shows an up-regulation of Trpc1 and Trpc4 transcripts and a decreased expression of Trpc5 and Trpc6 transcripts in L6-S1 DRG of CYP-treated rats.
Marc Freichel (70006) +7 more
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