Results 61 to 70 of about 2,132 (150)
, 2010 The mucolipin (TRPML) subfamily of transient receptor potential (TRP) cation channels consists of three members that play various roles in the regulation of membrane and protein sorting along endo-lysosomal pathways.
David A. Zeevi +4 more
core +1 more source
Interaction between TRPML channels and TRPV5/6.
, 2013 (A) Phylogenetic tree, based on full length sequence comparisons of human TRP channel proteins. (B) Phylogenetic tree, based on sequence comparisons of the pore forming domains of human TRP channel proteins.
Anthony J. Ricci (212303) +4 more
core +1 more source
Ca2+ Dyshomeostasis Disrupts Neuronal and Synaptic Function in Alzheimer’s Disease
Cells, 2020 Ca2+ homeostasis is essential for multiple neuronal functions and thus, Ca2+ dyshomeostasis can lead to widespread impairment of cellular and synaptic signaling, subsequently contributing to dementia and Alzheimer’s disease (AD).
John McDaid +2 more
doaj +1 more source
Autophagy, 2013 Lysosomal storage diseases are metabolic disorders characterized by the accumulation of acidic vacuoles, and are usually the consequence of the deficiency of an enzyme responsible for the metabolism of vesicular lipids, proteins or carbohydrates. In contrast, mucolipidosis type IV (MLIV), results from the absence of a vesicular Ca ( 2+) release ...
Venkatachalam, Kartik +2 more
openaire +2 more sources
Topology and function of nyctalopin in yeast and in-vitro translation systems. [PDF]
, 2010 Congenital stationary night blindness 1 (CSNBl) is a genetic disorder characterized in humans by night blindness, low visual acuity and myopia. CSNB 1 is caused by defects in genes that are involved in signaling between photoreceptors and depolarizing ...
Bojang, Pasano Pasano
core +1 more source
TRPML regula la migración y fagocitosis en hemocitos de Drosophila melanogaster mediante la liberación localizada de calcio desde los lisosomas [PDF]
, 2019 Tesis entregada a la Universidad de Chile en cumplimiento parcial de los requisitos para optar al grado de Doctor en Ciencias Biológicas con mención en Biología Molecular, Celular y Neurociencias.Lysosomal physiology has been shown to be important for ...
Edwards Jorquera, Sandra Sofía
core
Frontiers in Immunology, 2018 Monocytes and macrophages play important roles in health and disease. They have a central role in protecting the host, as they clear pathogens and modulate other immune cell functions through the production of regulatory molecules.
Giorgio Santoni +9 more
doaj +1 more source
Frontiers in ImmunologyPast research has identified that cancer cells sustain several cancer hallmarks by impairing function of the endolysosomal system (ES). Thus, maintaining the functional integrity of endolysosomes is crucial, which heavily relies on two key protein ...
Lina Ouologuem, Karin Bartel
doaj +1 more source
Structural insights into group II TRP channels
, 2020 The seven members of the TRP channel superfamily are divided into two main groups with five members comprising group I (TRPC/V/M/N/A) and TRPML (TRP MucoLipin) and TRPP (TRP Polycystin) making up group II. Group II channels share a high sequence homology
Li, Xiaochun +2 more
core +1 more source
Maximum likelihood phylogenetic tree of TRP channels.
, 2018 Various subfamilies of TRP channels are indicated by different colors where shades of each color indicates a class of TRP channels within a subfamily: TRPA subfamily (grey), TRPM (green), TRPV (yellow), TRPC (pink), TRPN (orange), TRPP (light blue), and ...
Charles D. Derby (5778215) +5 more
core +1 more source