Results 11 to 20 of about 1,799 (138)
Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3β/β-Catenin/MITF-axis [PDF]
Nature CommunicationsMelanoma arising from pigment-producing melanocytes is the deadliest form of skin cancer. Extensive ultraviolet light exposure is a major cause of melanoma and individuals with low levels of melanin are at particular risk.
Carla Abrahamian +21 more
doaj +4 more sources
Allosteric switching of Ca2+ permeability in the lysosomal ion channel TPC2 underpins biased agonist activation [PDF]
The EMBO JournalIon channels possess selectivity filters that are hardwired to ensure the selective passage of ions. Lysosomal two-pore channels are unusual as they are able to switch their cation selectivity in an agonist-specific manner, allowing differential control ...
Qianru Mu +19 more
doaj +3 more sources
TPC2: From Blond Hair to Melanoma? [PDF]
CancersTwo-pore channel 2 (TPC2) is expressed in endolysosomes throughout the human body, as well as in melanosomes of melanocytes. Melanocytes produce pigment, i.e., melanin, which determines hair and skin color but also protects from UV light.
Christian Grimm +2 more
exaly +4 more sources
Life Science Alliance, 2021 This study identifies the endolysosomal two-pore channel TPC2 as a potential novel drug target for age-related macular degeneration (AMD). Inhibition of TPC2 reduces two key clinical hallmarks of the AMD, retinal inflammation and formation of leaky ...
Yanfen Li +11 more
doaj +2 more sources
Targeting TPC2 sensitizes acute lymphoblastic leukemia cells to chemotherapeutics by impairing lysosomal function [PDF]
Cell Death and Disease, 2022 Despite novel therapy regimens and extensive research, chemoresistance remains a challenge in leukemia treatment. Of note, recent studies revealed lysosomes as regulators of cell death and chemotherapy response, suggesting this organelle is a novel ...
Franz Geisslinger +5 more
doaj +2 more sources
Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes [PDF]
Nature Communications, 2022 TPC2 is a lysosomal ion channel permeable to both calcium and sodium ions. Here, the authors show that TPC2 can selectively increase its calcium permeability when simultaneously challenged by both its natural activators- NAADP and PI(3,5)P2.
Yu Yuan +15 more
doaj +10 more sources
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function [PDF]
eLife, 2020 Ion selectivity is a defining feature of a given ion channel and is considered immutable. Here we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated (Calcraft et al., 2009; Guo et al., 2017; Jha et al., 2014; Ruas et al.,
Susanne Gerndt +22 more
doaj +5 more sources
Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2 [PDF]
Scientific Reports, 2021 Two-pore channel 2 (TPC2) resides in endolysosomal membranes but also in lysosome-related organelles such as the melanin producing melanosomes. Gain-of-function polymorphisms in hTPC2 are associated with decreased melanin production and blond hair color.
Ponsawan Netcharoensirisuk +14 more
doaj +2 more sources
PLoS Genetics, 2021 The endo-lysosomal two-pore channel (TPC2) has been established as an intracellular cation channel of significant physiological and pathophysiological relevance in recent years.
Julia Böck +7 more
doaj +2 more sources
Pharmacological ResearchThe lysosomal two-pore channel 2 (TPC2) modulates intracellular calcium (Ca2 +) signaling and has been implicated in inflammatory, cardiovascular, and neurodegenerative conditions, as well as cancer and viral infections.
John Parrington, Abeer Alharbi
exaly +3 more sources