A gain-of-function TPC2 variant R210C increases affinity to PI(3,5)P2 and causes lysosome acidification and hypopigmentation [PDF]
Nature Communications, 2023 TPC2 is an important organellar Na+/Ca2+ release channel which regulates function of lysosomes and lysosome-related organelles. Here, Wang et al.
Qiaochu Wang +14 more
doaj +2 more sources
Neurodegenerative Lysosomal Storage Disorders: TPC2 Comes to the Rescue!
Cells, 2022 Lysosomal storage diseases (LSDs) resulting from inherited gene mutations constitute a family of disorders that disturb lysosomal degradative function leading to abnormal storage of macromolecular substrates.
Sandra Prat Castro +5 more
doaj +2 more sources
Endolysosomal Ca2+ Signaling in Cancer: The Role of TPC2, From Tumorigenesis to Metastasis
Frontiers in Cell and Developmental Biology, 2019 Ca2+ homeostasis is dysregulated in cancer cells and affects processes such as tumorigenesis, angiogenesis, autophagy, progression, and metastasis.
John Parrington
exaly +3 more sources
Polymethoxyflavones from Kaempferia parviflora stimulate melanogenesis by blocking the TPC2 channel [PDF]
Scientific ReportsKaempferia parviflora, well-known as Thai ginseng (Krachaidum), has been used as a medicinal plant and food source for centuries. Its rhizome contains several flavonoids, particularly poly-O-methylated flavones (also known as polymethoxyflavones).
Pattara Poungcho +8 more
doaj +2 more sources
Contact, 2023 We have previously shown that in the developing trunk of zebrafish embryos, two-pore channel type 2 (TPC2)-mediated Ca 2+ release from endolysosomes plays a role in the formation of the skeletal slow muscle.
Keira L. Rice +4 more
doaj +2 more sources
Ryanodine Receptor 1 Is Dispensable for CD4<sup>+</sup> T-Cell Differentiation and Effector Function in Intestinal Inflammation Models. [PDF]
Eur J ImmunolRyr1 deletion reduces Ca2+ microdomains and delays global Ca2+ signaling in naïve CD4+ T cells but does not impair their activation, proliferation, or differentiation in vitro. Despite altered Ca2+ signaling, Ryr1 expression in CD4+ T cells was dispensable for their pathogenicity in murine models of intestinal inflammation.
Dostiar Tabrizi S +14 more
europepmc +2 more sources
Ionic Mechanisms of Two-Pore Channel Regulation of Vesicle Trafficking [PDF]
CellsThe endolysosomal system plays a pivotal role in cellular function. Before reaching lysosomes for degradation, the endocytosed cargoes are sorted at various stages of endosomal trafficking for recycling and/or rerouting.
Heng Zhang, Michael X. Zhu
doaj +2 more sources
Lysosomal channel TPC2 modulates microglia-endothelial signaling in choroidal angiogenesis. [PDF]
AngiogenesisPathological choroidal neovascularization underlies vision loss in neovascular age-related macular degeneration (nAMD), yet the molecular regulators coordinating vascular and immune components remain incompletely defined.
Lu Y +8 more
europepmc +2 more sources
Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's disease. [PDF]
J Cell BiolParkinson's disease results from degeneration of dopaminergic neurons in the midbrain, but the underlying mechanisms are unclear. Here, we identify novel crosstalk between depolarization-induced entry of Ca2+ and lysosomal cation release in maintaining ...
Gregori M +18 more
europepmc +6 more sources
The role of two-pore channels 2 (TPC2) in melanoma tumourigenesis and metastasis [PDF]
, 2023 Melanoma is an exceedingly aggressive and resistant to treatment form of cancer. Therefore, the identification of novel therapeutic approaches continues to be a crucial task.
Hanbashi, Ali
core +1 more source