Results 61 to 70 of about 1,793 (129)

Influence of taurolithocholate 3-sulphate on calcium content in cytosol and store of isolated mice hepatocytes

Біологічні студії, 2015
Momohydroxylated bile acids, including taurolitocholate (TLC) and its 3-sulphate (TLC-S), have been shown to increase [Ca2+]i in cytosol of rat hepatocytes [1, 2].
S. V. Bychkova
doaj   +1 more source

Evoked Weibel‐Palade Body Exocytosis Modifies the Endothelial Cell Surface by Releasing a Substrate‐Selective Phosphodiesterase

Advanced Science, Volume 11, Issue 16, April 24, 2024.
Weibel‐Palade bodies (WPB) are unique secretory organelles of endothelial cells. A new WPB constituent is identified, the glycerophosphodiester phosphodiesterase domain‐containing protein 5 (GDPD5) and it is shown that GDPD5 is released to the cell surface upon stimulation of WPB exocytosis.
Johannes Naß, Julian Terglane, Dagmar Zeuschner, Volker Gerke   +3 more
wiley   +1 more source

25 Years of Collaboration with A Genius: Deciphering Adenine Nucleotide Ca²⁺ Mobilizing Second Messengers Together with Professor Barry Potter

Molecules, 2020
Ca2+-mobilizing adenine nucleotide second messengers cyclic adenosine diphosphoribose, (cADPR), nicotinic acid adenine dinucleotide phosphate (NAADP), adenosine diphosphoribose (ADPR), and 2′deoxy-ADPR were discovered since the late 1980s.
Andreas H. Guse
doaj   +1 more source

Endolysosomal two‐pore channel 2 plays opposing roles in primary and metastatic malignant melanoma cells

Cell Biology International, Volume 48, Issue 4, Page 521-540, April 2024.
Abstract The ion channel two‐pore channel 2 (TPC2), localised on the membranes of acidic organelles such as endo‐lysosomes and melanosomes, has been shown to play a role in pathologies including cancer, and it is differently expressed in primary versus metastatic melanoma cells.
Samantha Barbonari, Antonella D'Amore, Ali A. Hanbashi, Fioretta Palombi, Anna Riccioli, John Parrington, Antonio Filippini   +6 more
wiley   +1 more source

Inhibition of lysosomal Ca2+ signalling disrupts dendritic spine structure and impairs wound healing in neurons

Communicative & Integrative Biology, 2017
A growing body of evidence suggests that lysosomes, which have traditionally been regarded as degradative organelles, can function as Ca2+ stores, regulated by the second messenger nicotinic acid adenine dinucleotide phosphate (NAADP).
Zahid Padamsey, Lindsay McGuinness, Nigel J. Emptage   +2 more
doaj   +1 more source

Cytoplasmic nanojunctions between lysosomes and sarcoplasmic reticulum are required for specific calcium signaling [v1; ref status: indexed, http://f1000r.es/32q]

F1000Research, 2014
Herein we demonstrate how nanojunctions between lysosomes and sarcoplasmic reticulum (L-SR junctions) serve to couple lysosomal activation to regenerative, ryanodine receptor-mediated cellular Ca2+ waves.
Nicola Fameli, Oluseye A. Ogunbayo, Cornelis van Breemen, A. Mark Evans   +3 more
doaj   +1 more source

Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca2+ signals between lysosomes and the endoplasmic reticulum

Cell Reports
Summary: Lysosomes and the endoplasmic reticulum (ER) are Ca2+ stores mobilized by the second messengers NAADP and IP3, respectively. Here, we establish Ca2+ signals between the two sources as fundamental building blocks that couple local release to ...
Yu Yuan, Vikas Arige, Ryo Saito, Qianru Mu, Gabriela C. Brailoiu, Gustavo J.S. Pereira, Stephen R. Bolsover, Marco Keller, Franz Bracher, Christian Grimm, Eugen Brailoiu, Jonathan S. Marchant, David I. Yule, Sandip Patel   +13 more
doaj   +1 more source

OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage

The Journal of Clinical Investigation
Regulated exocytosis is initiated by increased Ca2+ concentrations in close spatial proximity to secretory granules, which is effectively prevented when the cell is at rest. Here we showed that exocytosis of zymogen granules in acinar cells was driven by
Volodymyr Tsvilovskyy, Roger Ottenheijm, Ulrich Kriebs, Aline Schütz, Kalliope Nina Diakopoulos, Archana Jha, Wolfgang Bildl, Angela Wirth, Julia Böck, Dawid Jaślan, Irene Ferro, Francisco J. Taberner, Olga Kalinina, Staffan Hildebrand, Ulrich Wissenbach, Petra Weissgerber, Dominik Vogt, Carola Eberhagen, Stefanie Mannebach, Michael Berlin, Vladimir Kuryshev, Dagmar Schumacher, Koenraad Philippaert, Juan E. Camacho-Londoño, Ilka Mathar, Christoph Dieterich, Norbert Klugbauer, Martin Biel, Christian Wahl-Schott, Peter Lipp, Veit Flockerzi, Hans Zischka, Hana Algül, Stefan G. Lechner, Marina Lesina, Christian Grimm, Bernd Fakler, Uwe Schulte, Shmuel Muallem, Marc Freichel   +39 more
doaj   +1 more source

Endolysosomal two-pore channels regulate a conserved entry pathway for enteroviruses. [PDF]

J Gen Virol
Weng TC, Hsu BY, Wu TH, Gu XY, Cheng HH, Kung SH.   +5 more
europepmc   +1 more source

Allosteric switching of Ca²⁺ permeability in the lysosomal ion channel TPC2 underpins biased agonist activation. [PDF]

EMBO J
Mu Q, Saito R, Ozola F, Jaślan D, Chu PN, Zaki AM, Rubio-Alarcon M, Keller M, Yuan Y, Greig A, Silio V, Bracher F, Biggin PC, Brailoiu GC, Brailoiu E, Marchant JS, Grimm C, Lambie EJ, Rahman T, Patel S.   +19 more
europepmc   +1 more source