Results 51 to 60 of about 128,298 (159)

A novel transcriptional regulator, CdeR, modulates the type III secretion system via c-di-GMP signaling in Dickeya dadantii

Microbiology Spectrum
Dickeya dadantii is a bacterial pathogen that causes soft rot disease in many plant species worldwide, including temperate, subtropical, and tropical regions. This bacterium employs the type III secretion system (T3SS) to manipulate host immune responses.
Alaleh Ghasemi, Xiaochen Yuan, Ching-Hong Yang   +2 more
doaj   +1 more source

KdpD is a tandem serine histidine kinase that controls K+ pump KdpFABC transcriptionally and post-translationally

Nature Communications
Two-component systems, consisting of a histidine kinase and a response regulator, serve signal transduction in bacteria, often regulating transcription in response to environmental stimuli.
Jakob M. Silberberg, Sophie Ketter, Paul J. N. Böhm, Kristin Jordan, Marcel Wittenberg, Julia Grass, Inga Hänelt   +6 more
doaj   +1 more source

A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models

Nature Communications
Inherited retinopathies are devastating diseases that in most cases lack treatment options. Disease-modifying therapies that mitigate pathophysiology regardless of the underlying genetic lesion are desirable due to the diversity of mutations found in ...
Henri Leinonen, Jianye Zhang, Laurence M. Occelli, Umair Seemab, Elliot H. Choi, Luis Felipe L.P. Marinho, Janice Querubin, Alexander V. Kolesnikov, Anna Galinska, Katarzyna Kordecka, Thanh Hoang, Dominik Lewandowski, Timothy T. Lee, Elliott E. Einstein, David E. Einstein, Zhiqian Dong, Philip D. Kiser, Seth Blackshaw, Vladimir J. Kefalov, Marcin Tabaka, Andrzej Foik, Simon M. Petersen-Jones, Krzysztof Palczewski   +22 more
doaj   +1 more source

A genetically encoded biosensor to monitor dynamic changes of c-di-GMP with high temporal resolution

Nature Communications
Monitoring changes of signaling molecules and metabolites with high temporal resolution is key to understanding dynamic biological systems. Here, we use directed evolution to develop a genetically encoded ratiometric biosensor for c-di-GMP, a ubiquitous ...
Andreas Kaczmarczyk, Simon van Vliet, Roman Peter Jakob, Raphael Dias Teixeira, Inga Scheidat, Alberto Reinders, Alexander Klotz, Timm Maier, Urs Jenal   +8 more
doaj   +1 more source

A multiplexed fluorescent assay for independent second-messenger systems: decoding GPCR activation in living cells. [PDF]

J Biomol Screen, 2013
Tewson PH, Quinn AM, Hughes TE.
europepmc   +1 more source

Coordination of virulence factors and lifestyle transition in Pseudomonas aeruginosa through single-cell analysis

Communications Biology
Pseudomonas aeruginosa, a versatile Gram-negative opportunistic pathogen, relies on multiple virulence mechanisms, including a Type III Secretion System (T3SS) and several Type VI Secretion Systems (T6SS), to establish infections. The bacterial universal
Haozhe Chen, Gabriele Malengo, Liyun Wang, Olga Vogler, Mandy Renner, Timo Glatter, Nicole Paczia, Daniel Unterweger, Victor Sourjik, Andreas Diepold   +9 more
doaj   +1 more source

Cryogenic Gas-phase IR Spectroscopy on a Commercial Ion Mobility-Mass Spectrometry Platform. [PDF]

Anal Chem
Szekeres GP, Jordan JS, Riedel J, Horlebein J, Prabhu GRD, Götze M, Daly S, Warnke S, Pagel K.   +8 more
europepmc   +1 more source

Plant Extracts Target Biofilms to Alleviate Nutritional and Metabolic Disorders in Animals. [PDF]

Vet Sci
Wang Y, Song S, Gao S, Zhang X, Wang Y, Liu B.   +5 more
europepmc   +1 more source

Gintonin as a Lysophosphatidic Acid-Enriched GPCR Ligand System: Molecular Architecture and Receptor Pharmacology in <i>Panax ginseng</i>. [PDF]

Biomolecules
Kim KH, Yoo BC.
europepmc   +1 more source

Digital Leadership Scale for Clinical Nurses: Development and Validation of an Instrument. [PDF]

JMIR Nurs
Lee JH, Jung SY.
europepmc   +1 more source