Results 71 to 80 of about 130,287 (295)

Evidence that muscarinic cholinergic receptors selectively interact with either the cyclic AMP or the inositol phosphate second-messenger response systems [PDF]

, 1987
The relative capacities of muscarinic cholinergic receptor (MR) and bradykinin (BK)-receptor activation to increase phosphoinositide hydrolysis and to increase cytosolic Ca2+ were compared in NG108-15 neuroblastoma x glioma and 1321N1 human astrocytoma ...
Hepler, J R, Hughes, A R, Harden, T K
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Occurrence of Cyclic di-GMP-Modulating Output Domains in Cyanobacteria: an Illuminating Perspective

mBio, 2013
Microorganisms use a variety of metabolites to respond to external stimuli, including second messengers that amplify primary signals and elicit biochemical changes in a cell. Levels of the second messenger cyclic dimeric GMP (c-di-GMP) are regulated by a
Marco Agostoni, Benjamin J. Koestler, Christopher M. Waters, Barry L. Williams, Beronda L. Montgomery   +4 more
doaj   +1 more source

Compartmentalisation of second messenger signalling pathways

, 2014
The ability of a cell to transform an extracellular stimulus into a downstream event that directs specific physiological outcomes, requires the orchestrated, spatial and temporal response of many signalling proteins.
Baillie, George S., McCormick, Kristie
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The cyclic di-GMP receptor YcgR links the second messenger with the putrescine quorum sensing system in modulation of Dickeya oryzae motility

mBio
Dickeya oryzae is a prevalent pathogen capable of infecting a variety of crops and plants, and its cell motility plays a key role in invasion of host and subsequent systemic infection. We recently demonstrated that the bacterial second messenger c-di-GMP
Weihan Gu, Yufan Chen, Congcong Xie, Zhongqiao Chen, Huagui Gao, Yaping Zhu, Lian-hui Zhang, Lisheng Liao   +7 more
doaj   +1 more source

Second Messenger Systems in Alzheimer's Disease: A Quantitative Autoradiographic Study [PDF]

, 1990
Quantitative ligand binding autoradiography was used to map key components of second messenger systems in the CNS. [3H]-Forskolin binding to Gs-adenylate cyclase and [3H]-phorbol 12,13 dibutyrate (PDBu) binding to protein kinase C was investigated in ...
Horsburgh, Karen J
core  

Muhammad is the Messenger of God, may God bless him and grant him peace: In the divine books

, 2022
Through the preparation of our research, we were able to show many and abundant results and we cannot return them, but to make it easier for the dear reader, we talk to you about a summary of it in the following points: We divided our research into two ...
Agha Baba, Awat Muhammad, Kamal Al-Din, Nabaz Jamal, Hama Gharib, Bahra Salam, Amin, Abdulkarim Fattah, Ibrahim, Shamal Ahmed   +4 more
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Cyclic di-AMP alleviates periodontitis by activating PI3K/Akt/Nrf2 pathways

Frontiers in Cellular and Infection Microbiology
Emerging research demonstrates the regulatory effects of c-di-AMP, a bacterial-derived small molecule secondary messenger, on host immune responses and promoting resistance against infection-related diseases. This study aims to elucidate the role of c-di-
Kaihua Luo, Kaihua Luo, Qinrui Wu, Qinrui Wu, Zhengyi Li, Yajie Wu, Yajie Wu, Zhifei Su, Zhifei Su, Fangjie Zhou, Fangjie Zhou, Qinyang Li, Qinyang Li, Biao Ren, Yuqing Li, Jiyao Li, Jiyao Li, Xian Peng   +17 more
doaj   +1 more source