Results 61 to 70 of about 27,357 (285)
Recycling Endosomes and Viral Infection
Viruses, 2016 Many viruses exploit specific arms of the endomembrane system. The unique composition of each arm prompts the development of remarkably specific interactions between viruses and sub-organelles. This review focuses on the viral–host interactions occurring
Sílvia Vale-Costa, Maria João Amorim
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“Modulating Phosphoinositide Profiles as a Roadmap for Treatment in Acute Myeloid Leukemia”
Frontiers in Oncology, 2021 Polyphosphoinositides (PPIns) and their modulating enzymes are involved in regulating many important cellular functions including proliferation, differentiation or gene expression, and their deregulation is involved in human diseases such as metabolic ...
Stefano Ratti +14 more
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FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Nuclear Phosphoinositides as Key Determinants of Nuclear Functions
Biomolecules, 2023 Polyphosphoinositides (PPIns) are signalling messengers representing less than five per cent of the total phospholipid concentration within the cell.
Magdalena C. Vidalle +14 more
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Fatty-acyl chain profiles of cellular phosphoinositides [PDF]
, 2017 Phosphoinositides are rapidly turning-over phospholipids that play key roles in intracellular signaling and modulation of membrane effectors. Through technical refinements we have improved sensitivity in the analysis of the phosphoinositide PI, PIP, and ...
Traynor-Kaplan, Alexis +15 more
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IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Thin-layer chromatography of the phosphoinositides
Journal of Lipid Research, 1968 Thin-layer chromatography for the separation of mono-, di-, and triphosphoinositides (0.3-3 μg total phosphorus) is described.
F. Gonzalez-Sastre, J. Folch-Pi
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The yeast oxysterol binding protein Kes1 maintains sphingolipid levels. [PDF]
PLoS ONE, 2013 The oxysterol binding protein family are amphitropic proteins that bind oxysterols, sterols, and possibly phosphoinositides, in a conserved binding pocket.
Marissa A LeBlanc +6 more
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Measurement of phosphoinositides in the zebrafish Danio rerio
, 2013 Phosphoinositides represent a minor fraction of the total glycerolipids in cells. Despite the fact that phosphoinositides are present in small quantities, they have crucial roles during cell signaling and in regulating numerous intracellular processes ...
Divecha, Nullin +6 more
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Charting Endocrine Progenitors Across Species and Organs
Advanced Science, EarlyView.Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing +21 more
wiley +1 more source