Results 61 to 70 of about 27,020 (299)
Phosphoinositides regulate chloroplast processes [PDF]
Proceedings of the National Academy of Sciences, 2020 Phosphoinositides (PIs), the phosphorylated derivatives of the membrane glycerophospholipid phosphatidylinositol (PtdIns), are minor constituents of eukaryotic cell membranes that play an important role as signaling molecules (1). The inositol ring can be phosphorylated at three positions and the seven resulting phosphorylated forms are dynamically ...
openaire +2 more sources
Phosphoinositides in Cell Architecture [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 Inositol phospholipids have been implicated in almost all aspects of cellular physiology including spatiotemporal regulation of cellular signaling, acquisition of cellular polarity, specification of membrane identity, cytoskeletal dynamics, and regulation of cellular adhesion, motility, and cytokinesis.
Shewan, Annette +2 more
openaire +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A short history of inositol lipids
Journal of Lipid Research, 2016 The diverse family of inositol lipids is now known to be central to many aspects of cell biology. The route from the first discovery of inositol to our present day knowledge of inositol lipids spans more than 150 years and is long and complex.
Robin F. Irvine
doaj +1 more source
Capsaicin protects neuromuscular junctions from the inhibitory effects of botulinum neurotoxin A [PDF]
, 2008 Within 24 hrs after injecting botulinum neurotoxin A (BoNT/A) into the hindlimb, mice lost the toe spread reflex and developed progressive muscle weakness. At the same time, the compound muscle action potential amplitude decreased. Injection of capsaicin
Baskaran Thyagarajan +5 more
core +1 more source
Distinctive phosphoinositide- and Ca²⁺-binding properties of normal and cognitive performance–linked variant forms of KIBRA C2 domain [PDF]
, 2018 Kidney- and brain-expressed protein (KIBRA), a multifunctional scaffold protein with around 20 known binding partners, is involved in memory and cognition, organ size control via the Hippo pathway, cell polarity, and membrane trafficking.
Bagby, S +8 more
core +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Novel Ribonuclease Activity Differs between Fibrillarins from Arabidopsis thaliana
Frontiers in Plant Science, 2017 Fibrillarin is one of the most important nucleolar proteins that have been shown as essential for life. Fibrillarin localizes primarily at the periphery between fibrillar center and dense fibrillar component as well as in Cajal bodies.
Ulises Rodriguez-Corona +5 more
doaj +1 more source
The yeast oxysterol binding protein Kes1 maintains sphingolipid levels. [PDF]
PLoS ONE, 2013 The oxysterol binding protein family are amphitropic proteins that bind oxysterols, sterols, and possibly phosphoinositides, in a conserved binding pocket.
Marissa A LeBlanc +6 more
doaj +1 more source
eLife, 2023 African trypanosomes evade host immune clearance by antigenic variation, causing persistent infections in humans and animals. These parasites express a homogeneous surface coat of variant surface glycoproteins (VSGs).
Abdoulie O Touray +6 more
doaj +1 more source