Results 21 to 30 of about 13,157 (254)

Phosphoinositide Profile of the Mouse Retina

Cells, 2020
Phosphoinositides are known to play multiple roles in eukaryotic cells. Although dysregulation of phosphoinositide metabolism in the retina has been reported to cause visual dysfunction in animal models and human patients, our understanding of the ...
Stella Finkelstein, Sidney M. Gospe, Kai Schuhmann, Andrej Shevchenko, Vadim Y. Arshavsky, Ekaterina S. Lobanova   +5 more
doaj   +1 more source

Phosphoinositide 3-kinase is associated to the nucleus of HL-60 cells and is involved in their ATRA-induced granulocytic differentiation

European Journal of Histochemistry, 2009
Phosphoinositide 3-kinases (PI 3-kinases), a class of enzymes implicated in growth factor-induced mitogenic response and many other intracellular signalling pathways, act by phosphorylation at the D-3’-OH position of the myo-inositol ring of ...
V. Bertagnolo, A. Gonelli, F. Brugnoli, L.M. Neri, M. Marchisio   +4 more
doaj   +3 more sources

Phosphoinositides in Cell Architecture [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Inositol phospholipids have been implicated in almost all aspects of cellular physiology including spatiotemporal regulation of cellular signaling, acquisition of cellular polarity, specification of membrane identity, cytoskeletal dynamics, and regulation of cellular adhesion, motility, and cytokinesis.
Shewan, Annette, Eastburn, Dennis J., Mostov, Keith   +2 more
openaire   +5 more sources

Phosphoinositides and Photoreceptors [PDF]

Molecular Neurobiology, 2011
The importance of phosphoinositides (phosphorylated phosphatidyl inositol derivatives, PIs) for normal cellular function cannot be overstated. Although they represent a small fraction of the total phospholipid within the cell, they are essential regulators of many cellular functions.
openaire   +2 more sources

A human stem cell resource to decipher the biochemical and cellular basis of neurodevelopmental defects in Lowe syndrome

Biology Open, 2022
Human brain development is a complex process where multiple cellular and developmental events are coordinated to generate normal structure and function.
Bilal M. Akhtar, Priyanka Bhatia, Shubhra Acharya, Sanjeev Sharma, Yojet Sharma, Aswathy Bhuvanendran Nair Suseela Devi, Kavina Ganapathy, Anil Vasudevan, Padinjat Raghu   +8 more
doaj   +1 more source

Assessing the Presence of Phosphoinositides on Autophagosomal Membrane in Yeast by Live Cell Imaging. [PDF]

Microorganisms
The formation of autophagosomes mediating the sequestration of cytoplasmic materials is the central step of autophagy. Several phosphoinositides, which are signaling molecules on the membrane, are involved in autophagy.
Song JZ, Feng YH, Sergevnina V, Zhu J, Li H, Xie Z.   +5 more
europepmc   +2 more sources

Diverse Physiological Functions of FAB1 and Phosphatidylinositol 3,5-Bisphosphate in Plants

Frontiers in Plant Science, 2019
Biological membranes are predominantly composed of structural glycerophospholipids such as phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol. Of the membrane glycerophospholipids, phosphatidylinositol (PtdIns) and its phosphorylated
Tomoko Hirano, Masa H. Sato
doaj   +1 more source

Effects of thyroxine and 1-methyl, 2-mercaptoimidazol on phosphoinositides synthesis in rat liver

Lipids in Health and Disease, 2004
Background Phosphoinositides mediate one of the intracellular signal transduction pathways and produce a class of second messengers that are involved in the action of hormones and neurotransmitters on target cells.
Krasilnikova Oksana A, Babenko Nataliya A   +1 more
doaj   +1 more source

The Physiology of Phosphoinositides

Biological and Pharmaceutical Bulletin, 2007
Phosphoinositides are a family of phosphorylated derivatives of the membrane lipid phosphatidylinositol. These lipids are highly concentrated in distinct pools located in a cell's plasma membrane, endosomes or nucleus, where they function as ligands for phosphoinositide-binding proteins.
Sasaki, Takehiko, Sasaki, Junko, Sakai, Takahiro, Takasuga, Shunsuke, Suzuki, Akira   +4 more
openaire   +3 more sources

Structural organization and dynamics of FCHo2 docking on membranes

eLife, 2022
Clathrin-mediated endocytosis (CME) is a central trafficking pathway in eukaryotic cells regulated by phosphoinositides. The plasma membrane phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) plays an instrumental role in driving CME initiation. The F-BAR
Fatima El Alaoui, Ignacio Casuso, David Sanchez-Fuentes, Charlotte Arpin-Andre, Raissa Rathar, Volker Baecker, Anna Castro, Thierry Lorca, Julien Viaud, Stéphane Vassilopoulos, Adrian Carretero-Genevrier, Laura Picas   +11 more
doaj   +1 more source