Results 21 to 30 of about 27,357 (285)

Diverse Physiological Functions of FAB1 and Phosphatidylinositol 3,5-Bisphosphate in Plants

Frontiers in Plant Science, 2019
Biological membranes are predominantly composed of structural glycerophospholipids such as phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol. Of the membrane glycerophospholipids, phosphatidylinositol (PtdIns) and its phosphorylated
Tomoko Hirano, Masa H. Sato
doaj   +1 more source

Effects of thyroxine and 1-methyl, 2-mercaptoimidazol on phosphoinositides synthesis in rat liver

Lipids in Health and Disease, 2004
Background Phosphoinositides mediate one of the intracellular signal transduction pathways and produce a class of second messengers that are involved in the action of hormones and neurotransmitters on target cells.
Krasilnikova Oksana A, Babenko Nataliya A   +1 more
doaj   +1 more source

Structural organization and dynamics of FCHo2 docking on membranes

eLife, 2022
Clathrin-mediated endocytosis (CME) is a central trafficking pathway in eukaryotic cells regulated by phosphoinositides. The plasma membrane phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) plays an instrumental role in driving CME initiation. The F-BAR
Fatima El Alaoui, Ignacio Casuso, David Sanchez-Fuentes, Charlotte Arpin-Andre, Raissa Rathar, Volker Baecker, Anna Castro, Thierry Lorca, Julien Viaud, Stéphane Vassilopoulos, Adrian Carretero-Genevrier, Laura Picas   +11 more
doaj   +1 more source

DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

Nature Communications, 2017
Phosphoinositides are enriched in the nucleus and accumulate upon DNA damage but their role in responding to DNA damage is poorly defined. Here, the authors show that phosphoinositides rapidly accumulate at DNA damage sites and are required for ATR ...
Yu-Hsiu Wang, Anushya Hariharan, Giulia Bastianello, Yusuke Toyama, G. V. Shivashankar, Marco Foiani, Michael P. Sheetz   +6 more
doaj   +1 more source

Phosphatidylinositol-3,4,5-Triphosphate and Cellular Signaling: Implications for Obesity and Diabetes

Cellular Physiology and Biochemistry, 2015
Phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) is one of the most important phosphoinositides and is capable of activating a wide range of proteins through its interaction with their specific binding domains.
Prasenjit Manna, Sushil K. Jain
doaj   +1 more source

Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation

Frontiers in Physiology, 2014
Macropinosome formation requires the sequential activation of numerous signaling pathways that coordinate the actin-driven formation of plasma membrane protrusions (ruffles) and circular ruffles (macropinocytic cups), followed by the closure of these ...
Youhei eEgami, Tomohiko eTaguchi, Tomohiko eTaguchi, Masashi eMaekawa, Masashi eMaekawa, Hiroyuki eArai, Hiroyuki eArai, Nobukazu eAraki   +7 more
doaj   +1 more source

Phosphoinositides in the kidney

Journal of Lipid Research, 2019
Phosphoinositides (PIs) play pivotal roles in the regulation of many biological processes. The quality and quantity of PIs is regulated in time and space by the activity of PI kinases and PI phosphatases. The number of PI-metabolizing enzymes exceeds the
Leopoldo Staiano, Maria Antonietta De Matteis   +1 more
doaj   +1 more source

Characterizing IQGAP1-C Domain Binding to Phosphoinositides

, 2018
IQGAP1 is a ubiquitously expressed protein that is a member of the IQGAP family of scaffolding proteins. IQGAP1 has been found to regulate a diverse range of cellular processes including: cell migration, cell proliferation, cytoskeletal dynamics, and ...
Dallarosa, Christopher Anthony
core   +3 more sources

The emerging role of phosphoinositide clustering in intracellular trafficking and signal transduction [version 1; referees: 4 approved]

F1000Research, 2016
Phosphoinositides are master regulators of multiple cellular processes: from vesicular trafficking to signaling, cytoskeleton dynamics, and cell growth.
Laura Picas, Frederique Gaits-Iacovoni, Bruno Goud   +2 more
doaj   +1 more source

Phosphatidylinositol 4,5-Bisphosphate Mediates the Co-Distribution of Influenza A Hemagglutinin and Matrix Protein M1 at the Plasma Membrane

Viruses, 2022
The fully assembled influenza A virus (IAV) has on its surface the highest density of a single membrane protein found in nature—the glycoprotein hemagglutinin (HA) that mediates viral binding, entry, and assembly.
Prakash Raut, Bright Obeng, Hang Waters, Joshua Zimmerberg, Julie A. Gosse, Samuel T. Hess   +5 more
doaj   +1 more source