Results 21 to 30 of about 13,190 (254)

The Physiology of Phosphoinositides

Biological and Pharmaceutical Bulletin, 2007
Phosphoinositides are a family of phosphorylated derivatives of the membrane lipid phosphatidylinositol. These lipids are highly concentrated in distinct pools located in a cell's plasma membrane, endosomes or nucleus, where they function as ligands for phosphoinositide-binding proteins.
Sasaki, Takehiko, Sasaki, Junko, Sakai, Takahiro, Takasuga, Shunsuke, Suzuki, Akira   +4 more
openaire   +3 more sources

Structural organization and dynamics of FCHo2 docking on membranes

eLife, 2022
Clathrin-mediated endocytosis (CME) is a central trafficking pathway in eukaryotic cells regulated by phosphoinositides. The plasma membrane phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) plays an instrumental role in driving CME initiation. The F-BAR
Fatima El Alaoui, Ignacio Casuso, David Sanchez-Fuentes, Charlotte Arpin-Andre, Raissa Rathar, Volker Baecker, Anna Castro, Thierry Lorca, Julien Viaud, Stéphane Vassilopoulos, Adrian Carretero-Genevrier, Laura Picas   +11 more
doaj   +1 more source

DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

Nature Communications, 2017
Phosphoinositides are enriched in the nucleus and accumulate upon DNA damage but their role in responding to DNA damage is poorly defined. Here, the authors show that phosphoinositides rapidly accumulate at DNA damage sites and are required for ATR ...
Yu-Hsiu Wang, Anushya Hariharan, Giulia Bastianello, Yusuke Toyama, G. V. Shivashankar, Marco Foiani, Michael P. Sheetz   +6 more
doaj   +1 more source

Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation

Frontiers in Physiology, 2014
Macropinosome formation requires the sequential activation of numerous signaling pathways that coordinate the actin-driven formation of plasma membrane protrusions (ruffles) and circular ruffles (macropinocytic cups), followed by the closure of these ...
Youhei eEgami, Tomohiko eTaguchi, Tomohiko eTaguchi, Masashi eMaekawa, Masashi eMaekawa, Hiroyuki eArai, Hiroyuki eArai, Nobukazu eAraki   +7 more
doaj   +1 more source

Phosphatidylinositol-3,4,5-Triphosphate and Cellular Signaling: Implications for Obesity and Diabetes

Cellular Physiology and Biochemistry, 2015
Phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) is one of the most important phosphoinositides and is capable of activating a wide range of proteins through its interaction with their specific binding domains.
Prasenjit Manna, Sushil K. Jain
doaj   +1 more source

The emerging role of phosphoinositide clustering in intracellular trafficking and signal transduction [version 1; referees: 4 approved]

F1000Research, 2016
Phosphoinositides are master regulators of multiple cellular processes: from vesicular trafficking to signaling, cytoskeleton dynamics, and cell growth.
Laura Picas, Frederique Gaits-Iacovoni, Bruno Goud   +2 more
doaj   +1 more source

Phosphatidylinositol 4,5-Bisphosphate Mediates the Co-Distribution of Influenza A Hemagglutinin and Matrix Protein M1 at the Plasma Membrane

Viruses, 2022
The fully assembled influenza A virus (IAV) has on its surface the highest density of a single membrane protein found in nature—the glycoprotein hemagglutinin (HA) that mediates viral binding, entry, and assembly.
Prakash Raut, Bright Obeng, Hang Waters, Joshua Zimmerberg, Julie A. Gosse, Samuel T. Hess   +5 more
doaj   +1 more source

Lipid dynamics at dendritic spines

Frontiers in Neuroanatomy, 2014
Dynamic changes in the structure and composition of the membrane protrusions forming dendritic spines underlie memory and learning processes. In recent years a great effort has been made to characterize in detail the protein machinery that controls spine
Carlos Gerardo Dotti, Jose Antonio Esteban, Maria Dolores eLedesma   +2 more
doaj   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source