Results 1 to 10 of about 12,900 (249)

The analysis of tissue phospholipids: hydrolysis procedure and results with pig liver

Journal of Lipid Research, 1960
A procedure for the hydrolysis of phospholipids is described. The effect of alkali concentration, organic solvents, and length of hydrolysis have been studied. The initial reaction in the preferred solvent system appears to be a methanolysis.
G. Hübscher, J.N. Hawthorne, P. Kemp
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Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling

Biomolecules, 2023
Multiple inositol polyphosphate phosphatase (MINPP1) is an enigmatic enzyme that is responsible for the metabolism of inositol hexakisphosphate (InsP6) and inositol 1,3,4,5,6 pentakisphosphate (Ins(1,3,4,5,6)P5 in mammalian cells, despite being ...
Jia Yu, Barbara Leibiger, Shao-Nian Yang, Stephen B. Shears, Ingo B. Leibiger, Per-Olof Berggren, Christopher J. Barker   +6 more
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Finding a needle in a haystack: the role of electrostatics in target lipid recognition by PH domains. [PDF]

PLoS Computational Biology, 2012
Interactions between protein domains and lipid molecules play key roles in controlling cell membrane signalling and trafficking. The pleckstrin homology (PH) domain is one of the most widespread, binding specifically to phosphatidylinositol phosphates ...
Craig N Lumb, Mark S P Sansom
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HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain. [PDF]

PLoS ONE, 2009
The HD-PTP protein has been described as a tumor suppressor candidate and based on its amino acid sequence, categorized as a classical non-transmembrane protein tyrosine phosphatase (PTP).
Marie-Claude Gingras, Yu Ling Zhang, Dmitri Kharitidi, Alastair J Barr, Stefan Knapp, Michel L Tremblay, Arnim Pause   +6 more
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A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae

Molecular Systems Biology, 2010
Protein–metabolite networks are central to biological systems, but are incompletely understood. Here, we report a screen to catalog protein–lipid interactions in yeast.
Oriol Gallego, Matthew J Betts, Jelena Gvozdenovic‐Jeremic, Kenji Maeda, Christian Matetzki, Carmen Aguilar‐Gurrieri, Pedro Beltran‐Alvarez, Stefan Bonn, Carlos Fernández‐Tornero, Lars Juhl Jensen, Michael Kuhn, Jamie Trott, Vladimir Rybin, Christoph W Müller, Peer Bork, Marko Kaksonen, Robert B Russell, Anne‐Claude Gavin   +17 more
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Dynamism of PI4-Phosphate during Interactions with Human Erythrocytes in Entamoeba histolytica

Microorganisms, 2020
Phosphatidylinositol phosphates (PIPs) are involved in many cellular events as important secondary messengers. In Entamoeba histolytica, a human intestinal protozoan parasite, virulence-associated mechanisms such as cell motility, vesicular traffic ...
Natsuki Watanabe, Kumiko Nakada-Tsukui, Tomohiko Maehama, Tomoyoshi Nozaki   +3 more
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Synaptojanin2 Mutation Causes Progressive High-frequency Hearing Loss in Mice

Frontiers in Cellular Neuroscience, 2020
Progressive hearing loss is very common in the human population but we know little about the underlying molecular mechanisms. Synaptojanin2 (Synj2) has been reported to be involved, as a mouse mutation led to a progressive increase in auditory thresholds
Elisa Martelletti, Neil J. Ingham, Oliver Houston, Johanna C. Pass, Jing Chen, Walter Marcotti, Walter Marcotti, Karen P. Steel   +7 more
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The divergent ER-mitochondria encounter structures (ERMES) are conserved in parabasalids but lost in several anaerobic lineages with hydrogenosomes

BMC Biology, 2023
Background The endoplasmic reticulum (ER)-mitochondria membrane contact sites (MCS) are extensively studied in aerobic eukaryotes; however, little is known about MCS in anaerobes with reduced forms of mitochondria named hydrogenosomes.
Jitka Kučerová, Alois Zdrha, Abhishek Shinde, Karel Harant, Ivan Hrdý, Jan Tachezy   +5 more
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A TIR domain protein from E. faecalis attenuates MyD88-mediated signaling and NF-κB activation. [PDF]

PLoS ONE, 2014
Toll-like receptor signaling, mediated by functional Toll/interleukin-1 receptor (TIR) domains, plays a critical role in activating the innate immune response responsible for controlling and clearing infection.
Jun Zou, Arto S Baghdayan, Sarah J Payne, Nathan Shankar   +3 more
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Inactivation of Ymr1, Sjl2/3 phosphatases promotes stress resistance and longevity in wild type and Ras2G19V yeast

Biomedical Journal
In Saccharomyces cerevisiae, RAt Sarcoma (Ras) activity plays a central role in mediating the effect of glucose in decreasing stress resistance and longevity, with constitutive Ras activation mutations promoting cell growth and oncogenesis. Here, we used
M.G. Mirisola, V.D. Longo
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