Dual-color dSTORM imaging and ThunderSTORM image reconstruction and analysis to study the spatial organization of the nuclear phosphatidylinositol phosphates [PDF]
MethodsX, 2021 Single molecule localization microscopy (SMLM) provided an unprecedented insight into the sub-nuclear organization of proteins and nucleic acids but apart from the nuclear envelope the role of the nuclear lipids in the functional organization of the cell
Peter Hoboth +4 more
doaj +3 more sources
Quantitative structural characterization of phosphatidylinositol phosphates from biological samples [PDF]
Journal of Lipid Research, 2017 The aspects of cellular metabolism controlled by phosphatidylinositol phosphates (PtdInsPs) have been broadly expanded, and these phospholipids have drawn tremendous attention as pleiotropic signaling molecules.
Su Hee Kim +8 more
doaj +3 more sources
Phosphatidylinositol phosphates directly bind to neurofilament light chain (NF-L) for the regulation of NF-L self assembly [PDF]
Experimental and Molecular Medicine, 2011 Phosphatidylinositol phosphates (PtdInsPs) are ubiquitous membrane phospholipids that play diverse roles in cell growth and differentiation. To clarify the regulation mechanism acting on neurofilament light chain (NF-L) self assembly, we examined the ...
Pann Ghill Suh +2 more
exaly +3 more sources
Biology-enabling inositol phosphates, phosphatidylinositol phosphates and derivatives
Natural Product Reports, 2007 This review highlights inositol polyphosphate- and phosphatidylinositol-based small molecule probes that have advanced our understanding of intracellular signalling.
Gavin J Miller, Stuart Conway
exaly +6 more sources
VIPP1 rods engulf membranes containing phosphatidylinositol phosphates. [PDF]
Sci Rep, 2019 In cyanobacteria and plants, VIPP1 plays crucial roles in the biogenesis and repair of thylakoid membrane protein complexes and in coping with chloroplast membrane stress.
Theis J +7 more
europepmc +2 more sources
Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression. [PDF]
Sci Rep, 2019 Phosphoinositides (PIPs) participate in many cellular processes, including cancer progression; however, the metabolic features of PIPs associated with prostate cancer (PCa) are unknown. We investigated PIPs profiles in PTEN-deficient prostate cancer cell
Koizumi A +12 more
europepmc +2 more sources
Interactions of phosphatase and tensin homologue (PTEN) proteins with phosphatidylinositol phosphates: insights from molecular dynamics simulations of PTEN and voltage sensitive phosphatase. [PDF]
Biochemistry, 2014 The phosphatase and tensin homologue (PTEN) and the Ciona intestinalis voltage sensitive phosphatase (Ci-VSP) are both phosphatidylinositol phosphate (PIP) phosphatases that contain a C2 domain.
Kalli AC, Devaney I, Sansom MS.
europepmc +2 more sources
MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
Cell Reports, 2014 Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood.
Yves Dondelinger +15 more
doaj +2 more sources
Acutely Modifying Phosphatidylinositol Phosphates on Endolysosomes Using Chemically Inducible Dimerization Systems [PDF]
Bio-ProtocolPhosphoinositides are rare membrane lipids that mediate cell signaling and membrane dynamics. PI(4)P and PI(3)P are two major phosphoinositides crucial for endolysosomal functions and dynamics, making them the lipids of interest in many studies.
Wei Sheng Yap, Peter Kim, Maxime Boutry
doaj +2 more sources
Regulation of CK2 Activity by Phosphatidylinositol Phosphates* [PDF]
Journal of Biological Chemistry, 2005 The process of clathrin-coated vesicle (CCV) formation/disassembly involves numerous proteins that act cooperatively. Phosphorylation is an important regulatory mechanism governing protein interactions in CCVs, and many of the core and accessory proteins
V. Korolchuk, G. Cozier, G. Banting
semanticscholar +4 more sources