The activation of protein kinase C by the polyphosphoinositides phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-monophosphate [PDF]
FEBS Letters, 1987 Protein kinase C(PKC) is a Ca2+‐ and phospholipid‐dependent protein kinase which can be activated by diacylglycerol, a product of polyphosphoinositide hydrolysis. In this report, we show that the polyphosphoinositides L‐α‐phosphatidylinositol 4‐monophosphate (PI 4P) and L‐α‐phosphatidylinositol 4,5‐diphosphate (PI 4,5DP) can serve as phospholipid ...
I B Weinstein, C A O'Brian
exaly +4 more sources
Actin filament assembly by myristoylated alanine-rich C kinase substrate-phosphatidylinositol-4,5-diphosphate signaling is critical for dendrite branching. [PDF]
Mol Biol Cell, 2008 Dendrites undergo extensive growth and branching at early stages, but relatively little is known about the molecular mechanisms underlying these processes. Here, we show that increasing the level of myristoylated, alanine-rich C kinase substrate (MARCKS), a prominent substrate of protein kinase C and a phosphatidylinositol-4,5-diphosphate [PI(4,5)P2 ...
Li H, Chen G, Zhou B, Duan S.
europepmc +5 more sources
Localization of the ATP/Phosphatidylinositol 4,5 Diphosphate-binding Site to a 39-Amino Acid Region of the Carboxyl Terminus of the ATP-regulated K+ Channel Kir1.1 [PDF]
Journal of Biological Chemistry, 2002 Intracellular ATP and membrane-associated phosphatidylinositol phospholipids, like PIP(2) (PI(4,5)P(2)), regulate the activity of ATP-sensitive K(+) (K(ATP)) and Kir1.1 channels by direct interaction with the pore-forming subunits of these channels. We previously demonstrated direct binding of TNP-ATP (2',3'-O-(2,4,6-trinitrophenylcyclo-hexadienylidene)
Ke, Dong +3 more
openaire +3 more sources
Membrane association of the PTEN tumor suppressor: molecular details of the protein-membrane complex from SPR binding studies and neutron reflection. [PDF]
PLoS ONE, 2012 The structure and function of the PTEN phosphatase is investigated by studying its membrane affinity and localization on in-plane fluid, thermally disordered synthetic membrane models.
Siddharth Shenoy +6 more
doaj +2 more sources
Journal of Biological Chemistry, 1986 The metabolism of phosphatidylinositol (PtdIns) was studied in a mink lung epithelial cell line and its subclones transformed by feline sarcoma viruses containing either the v-fms or v-fes oncogenes. The transformed cell lines had a higher rate of PtdIns turnover but did not have elevated levels of phosphorylated PtdIns species or PtdIns kinase ...
Charles Sherr, C W Rettenmier, C O ROCK
exaly +3 more sources
CDP-Diacylglycerol Synthases (CDS): Gateway to Phosphatidylinositol and Cardiolipin Synthesis
Frontiers in Cell and Developmental Biology, 2020 Cytidine diphosphate diacylglycerol (CDP-DAG) is a key intermediate in the synthesis of phosphatidylinositol (PI) and cardiolipin (CL). Both PI and CL have highly specialized roles in cells.
Nicholas J. Blunsom, Shamshad Cockcroft
doaj +1 more source
When fat is not bad: the regulation of actin dynamics by phospholipid signaling molecules
Frontiers in Plant Science, 2014 The actin cytoskeleton plays a key role in the plant morphogenesis and is involved in polar cell growth, movement of subcellular organelles, cell division, and plant defense.
Roman ePleskot +3 more
doaj +1 more source
Journal of Lipid Research, 1987 Addition of platelet-activating factor (PAF) to cells doubly labeled with [14C]glycerol plus [3H]arachidonic acid resulted in a transient decrease of [14C]glycerol-labeled phosphatidylinositol (PI) and a transient increase of [14C]glycerol-labeled ...
T Okayasu, K Hasegawa, T Ishibashi
doaj +1 more source
RASSF4 controls SOCE and ER–PM junctions through regulation of PI(4,5)P2
Journal of Cell Biology, 2017 RAS association domain family 4 (RASSF4) is involved in tumorigenesis and regulation of the Hippo pathway. In this study, we identify new functional roles of RASSF4.
Yu-Ju Chen +3 more
semanticscholar +1 more source
Journal of Biological Chemistry, 1985 Platelets, and a variety of other cells, rapidly hydrolyze the phosphoinositides in response to stimulation by agonists. One of the products of hydrolysis of phosphatidylinositol 4,5-diphosphate is inositol 1,4,5-trisphosphate, which recently has been ...
T. Connolly, T. E. Bross, P. Majerus
semanticscholar +1 more source