Results 11 to 20 of about 19,153 (124)

Tissue-specific targeting of the ARF6 signalling axis for type 2 diabetes and obesity: From mechanism to nanodelivery. [PDF]

Clin Transl Med
Multitissue targeting and nanodelivery strategies centred on ADP‐ribosylation factor 6 for type 2 diabetes and insulin resistance. Abstract Disorders of glucose metabolism, particularly type 2 diabetes and obesity, remain major therapeutic challenges because they involve dysfunction across multiple tissues, including pancreatic β‐cells, peripheral ...
Wang Y, He Y, Xiu Z, Wang H.
europepmc   +2 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Affinity-Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6-PP-InsP₅-Binding Proteins in Plants. [PDF]

Adv Sci (Weinh)
ABSTRACT Inositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in plants, the functions of the recently discovered isomer 4/6‐PP‐InsP5 remain largely unknown ...
Ritter K, Gaugler V, Stolze SC, Ghosh R, Jayamon A, Yadav R, Wollensack F, Laha D, Nakagami H, Schaaf G, Jessen HJ.   +10 more
europepmc   +2 more sources

Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells. [PDF]

Chembiochem
Glycerophospholipids are the main class of phospholipids, essential for membrane structure, compartmentalization, and cellular signaling. To study their roles, innovative probes and advanced bioconjugation strategies have been developed, including by de novo lipid synthesis and bioorthogonal conjugation chemistry.
Beauvais B, Rohokale R, Mamputu S, Lupu I, Guo Z, Balieu S.   +5 more
europepmc   +2 more sources

Membrane surface recognition by the ASAP1 PH domain and consequences for interactions with the small GTPase Arf1

Science Advances, 2020
The ASAP1 PH domain binds to PIP2 membranes, experiences conformational shifts, and recognizes Arf1 to initiate GTPase activity. Adenosine diphosphate–ribosylation factor (Arf) guanosine triphosphatase–activating proteins (GAPs) are enzymes that need to ...
O. Soubias, S. Pant, Frank Heinrich, Frank Heinrich, Yue Zhang, N. Roy, Jess Li, X. Jian, M. Yohe, P. Randazzo, M. Lösche, M. Lösche, E. Tajkhorshid, R. Byrd   +13 more
semanticscholar   +1 more source

Molecular Dynamics Simulation of Kir6.2 Variants Reveals Potential Association with Diabetes Mellitus

Molecules
Diabetes mellitus (DM) represents a problem for the healthcare system worldwide. DM has very serious complications such as blindness, kidney failure, and cardiovascular disease.
Mohamed E. Elangeeb, Imadeldin Elfaki, Ali M. S. Eleragi, Elsadig Mohamed Ahmed, Rashid Mir, Salem M. Alzahrani, Ruqaiah I. Bedaiwi, Zeyad M. Alharbi, Mohammad Muzaffar Mir, Mohammad Rehan Ajmal, Faris Jamal Tayeb, Jameel Barnawi   +11 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The Neurosecretory Vesicle Protein Phogrin Functions as a Phosphatidylinositol Phosphatase to Regulate Insulin Secretion*

Journal of Biological Chemistry, 2010
Phogrin is a transmembrane protein expressed in cells with stimulus-coupled peptide hormone secretion, including pancreatic beta cells, in which it is localized to the membrane of insulin-containing dense-core vesicles.
L. Caromile, A. Oganesian, Scott A. Coats, R. Seifert, D. Bowen-Pope   +4 more
semanticscholar   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets.

Journal of Biological Chemistry, 1983
The addition of thrombin to human platelets prelabeled with 32Pi led to significant loss of radioactivity in phosphatidylinositol 4,5-bisphosphate within 5 s, followed by recovery or even increase by 2 min.
B. Agranoff, P. Murthy, E. Seguin
semanticscholar   +1 more source