Results 41 to 50 of about 837,784 (254)

Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site. [PDF]

PLoS ONE, 2012
BACKGROUND: Pleckstrin homology (PH) domains are common membrane-targeting modules and their best characterized ligands are a set of important signaling lipids that include phosphatidylinositol phosphates (PtdInsPs). PH domains recognize PtdInsPs through
Kanchan Anand, Kenji Maeda, Anne-Claude Gavin   +2 more
doaj   +1 more source

The phosphatidylinositol 3‐phosphate‐binding FYVE finger [PDF]

FEBS Letters, 2002
The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3‐phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P‐containing ...
Stenmark, Harald, Aasland, Rein, Driscoll, Paul C.   +2 more
openaire   +2 more sources

Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling

Biomolecules, 2023
Multiple inositol polyphosphate phosphatase (MINPP1) is an enigmatic enzyme that is responsible for the metabolism of inositol hexakisphosphate (InsP6) and inositol 1,3,4,5,6 pentakisphosphate (Ins(1,3,4,5,6)P5 in mammalian cells, despite being ...
Jia Yu, Barbara Leibiger, Shao-Nian Yang, Stephen B. Shears, Ingo B. Leibiger, Per-Olof Berggren, Christopher J. Barker   +6 more
doaj   +1 more source

Nanoscale mapping of nuclear phosphatidylinositol phosphate landscape by dual-color dSTORM.

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2021
Current models of gene expression, which are based on single-molecule localization microscopy, acknowledge protein clustering and formation of transcriptional condensates as a driving force of gene expression.
P. Hoboth, M. Sztacho, Ondřej Šebesta, Martin Schätz, E. Castaño, P. Hozák   +5 more
semanticscholar   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain. [PDF]

PLoS ONE, 2009
The HD-PTP protein has been described as a tumor suppressor candidate and based on its amino acid sequence, categorized as a classical non-transmembrane protein tyrosine phosphatase (PTP).
Marie-Claude Gingras, Yu Ling Zhang, Dmitri Kharitidi, Alastair J Barr, Stefan Knapp, Michel L Tremblay, Arnim Pause   +6 more
doaj   +1 more source

Transformations of phosphatidylinositol phosphates in the outer and inner nuclear membrane are linked to synthesis and restitution of cellular membranes

, 2011
The ultimate goal in phosphoinositides cellular metabolism is to decipher their global functional organization and coordination of the com- partmentalized signaling processes.
A. Slomiany, B. Slomiany
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol Phosphates as Co-activators of Ca2+ Binding to C2 Domains of Synaptotagmin 1*

Journal of Biological Chemistry, 2006
Ca2+-dependent phospholipid binding to the C2A and C2B domains of synaptotagmin 1 is thought to trigger fast neurotransmitter release, but only Ca2+ binding to the C2B domain is essential for release.
Liyi Li, Ok-Ho Shin, J. Rhee, D. Araç, J. Rah, J. Rizo, T. Südhof, Christian Rosenmund   +7 more
semanticscholar   +1 more source