Results 31 to 40 of about 837,784 (254)

Membrane Phospholipids and Polyphosphates as Cofactors and Binding Molecules of SERPINA12 (vaspin)

Molecules, 2020
Visceral adipose tissue derived serine protease inhibitor (vaspin) is a member of the serpin family and has been shown to have beneficial effects on glucose tolerance, insulin stability as well as adipose tissue inflammation, parameters seriously ...
Catherine A. Tindall, Sebastian Dommel, Veronika Riedl, David Ulbricht, Stefanie Hanke, Norbert Sträter, John T. Heiker   +6 more
doaj   +1 more source

Myoinositol in Autoimmune Thyroiditis

Frontiers in Endocrinology, 2022
Myoinositol (Myo) is an isoform of inositol, a cyclic polyol with 6 hydroxyl groups. Myo is mainly derived from dietary intake while its endogenous production is generated from glucose by enzymatic reactions.
Sabrina Rosaria Paparo, Silvia Martina Ferrari, Armando Patrizio, Giusy Elia, Francesca Ragusa, Chiara Botrini, Eugenia Balestri, Fabrizio Guarneri, Salvatore Benvenga, Salvatore Benvenga, Salvatore Benvenga, Alessandro Antonelli, Poupak Fallahi   +12 more
doaj   +1 more source

Phosphatidylinositol(4,5)bisphosphate and Phosphatidylinositol(4)phosphate in Plant Tissues [PDF]

Plant Physiology, 1989
Pea (Pisum sativum) leaf discs or swimming suspensions of Chlamydomonas eugametos were radiolabeled with [(3)H]myo-inositol or [(32)P]Pi and the lipids were extracted, deacylated, and their glycerol moieties removed. The resulting inositol trisphosphate and bisphosphate fractions were examined by periodate degradation, reduction and dephosphorylation ...
R F, Irvine, A J, Letcher, D J, Lander, B K, Drøbak, A P, Dawson, A, Musgrave   +5 more
openaire   +2 more sources

An emerging role for PI5P in T cell biology

Frontiers in Immunology, 2013
Phosphoinositides are critical regulators in cell biology. Phosphatidylinositol 4,5-bisphosphate, also known as PI(4,5)P2 or PIP2, was the first variety of phosphoinositide to enter in the T cell signaling scene.
Jacques A Nunes, Jacques A Nunes, Jacques A Nunes, Jacques A Nunes, Geoffrey eGuittard   +4 more
doaj   +1 more source

Electrostatic Interaction Between NS1 and Negatively Charged Lipids Contributes to Flavivirus Replication Organelles Formation

Frontiers in Microbiology, 2021
Flavivirus replication occurs in membranous replication compartments, also known as replication organelles (ROs) derived from the host ER membrane. Our previous study showed that the non-structural (NS) protein 1 (NS1) is the essential factor for RO ...
Yali Ci, Yali Ci, Yang Yang, Yang Yang, Caimin Xu, Caimin Xu, Cheng-Feng Qin, Lei Shi, Lei Shi   +8 more
doaj   +1 more source

Type I Phosphatidylinositol-4-phosphate 5-Kinases Synthesize the Novel Lipids Phosphatidylinositol 3,5-Bisphosphate and Phosphatidylinositol 5-Phosphate [PDF]

Journal of Biological Chemistry, 1998
Inositol phospholipids regulate a variety of cellular processes including proliferation, survival, vesicular trafficking, and cytoskeletal organization. Recently, two novel phosphoinositides, phosphatidylinositol-3,5-bisphosphate (PtdIns-3,5-P2) and phosphatidylinositol- 5-phosphate (PtdIns-5-P), have been shown to exist in cells.
K F, Tolias, L E, Rameh, H, Ishihara, Y, Shibasaki, J, Chen, G D, Prestwich, L C, Cantley, C L, Carpenter   +7 more
openaire   +2 more sources

Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2

Nature Communications, 2019
Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of late endosomes and lysosomes (LELs). Here authors unveil a mechanism by which PI(4,5)P2/PI(3,4)P2 allosterically enhances ORP1-mediated cholesterol exit from ...
Jiangqing Dong, Ximing Du, Huan Wang, Jue Wang, Chang Lu, Xiang Chen, Zhiwen Zhu, Zhipu Luo, Li Yu, Andrew J. Brown, Hongyuan Yang, Jia-Wei Wu   +11 more
doaj   +1 more source

Evidence for a specific phosphatidylinositol 4-phosphate phosphatase in human erythrocyte membranes.

Journal of Lipid Research, 1984
Human erythrocyte membranes exhibit a specific phosphatidylinositol 4-phosphate phosphohydrolase (PtdIns4P phosphatase) activity which hydrolyzes PtdIns4P and lysoPtdIns4P but not phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) or lysoPtdIns(4,5)P2.
S E Mack, F B Palmer
doaj   +1 more source

Finding a needle in a haystack: the role of electrostatics in target lipid recognition by PH domains. [PDF]

PLoS Computational Biology, 2012
Interactions between protein domains and lipid molecules play key roles in controlling cell membrane signalling and trafficking. The pleckstrin homology (PH) domain is one of the most widespread, binding specifically to phosphatidylinositol phosphates ...
Craig N Lumb, Mark S P Sansom
doaj   +1 more source

The analysis of tissue phospholipids: hydrolysis procedure and results with pig liver

Journal of Lipid Research, 1960
A procedure for the hydrolysis of phospholipids is described. The effect of alkali concentration, organic solvents, and length of hydrolysis have been studied. The initial reaction in the preferred solvent system appears to be a methanolysis.
G. Hübscher, J.N. Hawthorne, P. Kemp
doaj   +1 more source