BMJ, 1987 The cell nucleus is the information centre of the cell. It is responsible for copying highly selected regions of the genome into ribonucleic acid (RNA) and for supplying precisely regulated amounts of specific RNA molecules to the cytoplasm, where they are translated into proteins.
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Lipid Microdomains in Cell Nucleus [PDF]
Molecular Biology of the Cell, 2008 It is known that nuclear lipids play a role in proliferation, differentiation, and apoptotic process. Cellular nuclei contain high levels of phosphatidylcholine and sphingomyelin, which are partially linked with cholesterol and proteins to form lipid–protein complexes.
Giacomo, Cascianelli +6 more
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Joint profiling of DNA methylation and chromatin architecture in single cells. [PDF]
, 2019 We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the ...
AD Schmitt +31 more
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Negative Correlation between the Diffusion Coefficient and Transcriptional Activity of the Glucocorticoid Receptor [PDF]
, 2017 The glucocorticoid receptor (GR) is a transcription factor, which interacts with DNA and other cofactors to regulate gene transcription. Binding to other partners in the cell nucleus alters the diffusion properties of GR.
Horio, Takashi +3 more
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A cell line derived from BBN (N-butyl-N-[4-hydroxybutyl]-nitrosamine)-induced rat bladder cancer: establishment and scanning electron microscopic cell surface characteristics [PDF]
, 1978 This research was performed to establish a cell line from experimental bladder tumor and to discuss the biological characteristics of the cell line so established. Tissue cultures of epithelial cells were derived from a rat bladder cancer induced by BBN.
Nishi, Mitsuo
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The Role of Nuclear Insulin and IGF1 Receptors in Metabolism and Cancer
Biomolecules, 2021 Insulin (InsR) and insulin-like growth factor-1 (IGF1R) receptors mediate the metabolic and growth-promoting actions of insulin and IGF1/IGF2, respectively.
Haim Werner, Rive Sarfstein, Zvi Laron
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Millisecond single-molecule localization microscopy combined with convolution analysis and automated image segmentation to determine protein concentrations in complexly structured, functional cells, one cell at a time [PDF]
, 2015 We present a single-molecule tool called the CoPro (Concentration of Proteins) method that uses millisecond imaging with convolution analysis, automated image segmentation and super-resolution localization microscopy to generate robust estimates for ...
Leake, Mark C., Wollman, Adam J. M.
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Modular Nanotransporters for Nuclear-Targeted Delivery of Auger Electron Emitters
Frontiers in Pharmacology, 2018 This review describes artificial modular nanotransporters (MNTs) delivering their cargos into target cells and then into the nuclei – the most vulnerable cell compartment for most anticancer agents and especially for radionuclides emitting short-range ...
Alexander S. Sobolev +1 more
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Distribution of catecholamine fibers in the cochlear nucleus of horseshoe bats and mustache bats [PDF]
, 1988 The glyoxylic-acid-induced fluorescence technique was applied to demonstrate patterns of catecholaminergic innervation within the auditory brainstem of echolocating bats and the house mouse.
Björklund +38 more
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Actomyosin contractility rotates the cell nucleus [PDF]
Scientific Reports, 2013 The nucleus of the eukaryotic cell functions amidst active cytoskeletal filaments, but its response to the stresses carried by these filaments is largely unexplored. We report here the results of studies of the translational and rotational dynamics of the nuclei of single fibroblast cells, with the effects of cell migration suppressed by plating onto ...
Kumar, Abhishek +4 more
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