Results 41 to 50 of about 6,341,201 (297)
The Role of Nuclear Insulin and IGF1 Receptors in Metabolism and Cancer
Biomolecules, 2021 Insulin (InsR) and insulin-like growth factor-1 (IGF1R) receptors mediate the metabolic and growth-promoting actions of insulin and IGF1/IGF2, respectively.
Haim Werner, Rive Sarfstein, Zvi Laron
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Transport in and out of the cell nucleus [PDF]
Biochemical Society Transactions, 1998 A hallmark of eukaryotic cells is their separation into compartments. These compartments are surrounded by membranes that are impermeable to macromolecules. As most proteins are synthesised in the cytoplasm, specific transport systems have evolved to allow proteins to be imported from the cytoplasm into these compartments.
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Microglial responses around intrinsic CNS neurons are correlated with axonal regeneration [PDF]
, 2010 Background: Microglia/macrophages and lymphocytes (T-cells) accumulate around motor and primary sensory neurons that are regenerating axons but there is little or no microglial activation or T-cell accumulation around axotomised intrinsic CNS neurons ...
Bernadette ZY Wong +20 more
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The dynamic landscape of the cell nucleus [PDF]
Molecular Reproduction and Development, 2009 AbstractWhile the cell nucleus was described for the first time almost two centuries ago, our modern view of the nuclear architecture is primarily based on studies from the last two decades. This surprising late start coincides with the development of new, powerful strategies to probe for the spatial organization of nuclear activities in both fixed and
Christopher M, Austin, Michel, Bellini
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Alteration of actin cytoskeletal organisation in fetal akinesia deformation sequence
Scientific ReportsFetal akinesia deformation sequence (FADS) represents the severest form of congenital myasthenic syndrome (CMS), a diverse group of inherited disorders characterised by impaired neuromuscular transmission.
Ramona Jühlen +4 more
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Endocrine Connections, 2018 Background: Computerized image analysis seems to represent a promising diagnostic possibility for thyroid tumors. Our aim was to evaluate the discriminatory diagnostic efficiency of computerized image analysis of cell nuclei from histological materials ...
Flávia O Valentim +10 more
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FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
BMJ, 1987 The cell nucleus is the information centre of the cell. It is responsible for copying highly selected regions of the genome into ribonucleic acid (RNA) and for supplying precisely regulated amounts of specific RNA molecules to the cytoplasm, where they are translated into proteins.
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Systems biology in the cell nucleus [PDF]
Journal of Cell Science, 2005 The mammalian nucleus is arguably the most complex cellular organelle. It houses the vast majority of an organism's genetic material and is the site of all major genome regulatory processes. Reductionist approaches have been spectacularly successful at dissecting at the molecular level many of the key processes that occur within the nucleus ...
Stanislaw, Gorski, Tom, Misteli
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