Results 61 to 70 of about 1,388,881 (305)

The Emerging Roles of Heterochromatin in Cell Migration

Frontiers in Cell and Developmental Biology, 2020
Cell migration is a key process in health and disease. In the last decade an increasing attention is given to chromatin organization in migrating cells. In various types of cells induction of migration leads to a global increase in heterochromatin levels.
Gabi Gerlitz
doaj   +1 more source

The role of vimentin–nuclear interactions in persistent cell motility through confined spaces

New Journal of Physics, 2021
The ability of cells to move through small spaces depends on the mechanical properties of the cellular cytoskeleton and on nuclear deformability. In mammalian cells, the cytoskeleton is composed of three interacting, semi-flexible polymer networks: actin,
Sarthak Gupta, Alison E Patteson, J M Schwarz   +2 more
doaj   +1 more source

From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein [PDF]

, 2012
Mutations in the motor protein cytoplasmic dynein have been found to cause Charcot-Marie-Tooth disease, spinal muscular atrophy, and severe intellectual disabilities in humans. In mouse models, neurodegeneration is observed.
A. Friedman, A. G. Hendricks, A. G. Hendricks, A. J. Roberts, A. Kunwar, A. P. Carter, A. V. Kuznetsov, A. V. Kuznetsov, Anotida Madzvamuse, C. Korn, C. L. Brown, Caroline A. Garrett, D. A. Smith, D. Tsygankov, E. Bananis, J. L. Ross, J. Munárriz, J. W. Driver, J. W. Murray, J. W. Wojcieszyn, K. Imamula, K. M. Ori-McKenney, K. S. Zadeh, L. W. Duchen, Laurie Crossley, M. A. Gee, M. B. Harms, M. Bier, M. H. Willemsen, M. Hafezparast, M. N. Weedon, M. Schliwa, M. Schuster, M. Schuster, Majid Hafezparast, O. J. Driskell, P. Ashwin, R. D. Vale, S. A. Burgess, S. Ally, S. C. Schaffner, S. Hoepfner, S. Lubery, S. Mitragotri, S. Mukherji, T. D. Pollard, T. Kon, V. Soppina, W. Deng, X. J. Chen, Y. Gao, Y. Imafuku, Y. Zhang, Y. Zhang   +53 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Follicular thyroid lesions: is there a discriminatory potential in the computerized nuclear analysis?

Endocrine Connections, 2018
Background: Computerized image analysis seems to represent a promising diagnostic possibility for thyroid tumors. Our aim was to evaluate the discriminatory diagnostic efficiency of computerized image analysis of cell nuclei from histological materials ...
Flávia O Valentim, Bárbara P Coelho, Hélio A Miot, Caroline Y Hayashi, Danilo T A Jaune, Cristiano C Oliveira, Mariângela E A Marques, José Vicente Tagliarini, Emanuel C Castilho, Paula Soares, Gláucia M F S Mazeto   +10 more
doaj   +1 more source

Novel Scaffold Based on Chitosan Hydrogels/Phthalated Cashew Gum for Supporting Human Dental Pulp Stem Cells

Pharmaceuticals, 2023
Hydrogels are structures that have value for application in the area of tissue engineering because they mimic the extracellular matrix. Naturally obtained polysaccharides, such as chitosan (CH) and cashew gum, are materials with the ability to form ...
Yulla Klinger de Carvalho Leite, Antônia Carla de Jesus Oliveira, Patrick Veras Quelemes, Napoleão Martins Argolo Neto, Camila Ernanda Sousa de Carvalho, Huanna Waleska Soares Rodrigues, Michel Muálem de Moraes Alves, Fernando Aécio de Amorim Carvalho, Daniel Dias Rufino Arcanjo, Edson Cavalcanti da Silva-Filho, Alessandra Durazzo, Massimo Lucarini, Maria Acelina Martins de Carvalho, Durcilene Alves da Silva, José Roberto de Souza de Almeida Leite   +14 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Impact of Optical Undersampling on the Ca2+ Signal Resolution in Ca2+ Imaging of Spontaneous Neuronal Activity

Journal of Integrative Neuroscience
Background: In neuroscience, Ca2+ imaging is a prevalent technique used to infer neuronal electrical activity, often relying on optical signals recorded at low sampling rates (3 to 30 Hz) across multiple neurons simultaneously.
Katarina D. Milicevic, Violetta O. Ivanova, Tina N. Brazil, Cesar A. Varillas, Yan M.D. Zhu, Pavle R. Andjus, Srdjan D. Antic   +6 more
doaj   +1 more source

Thermal instability of cell nuclei

New Journal of Physics, 2014
DNA is known to be a mechanically and thermally stable structure. In its double stranded form it is densely packed within the cell nucleus and is thermo-resistant up to $70\:^\circ {\rm{C}}$ .
Enrico Warmt, Tobias R Kießling, Roland Stange, Anatol W Fritsch, Mareike Zink, Josef A Käs   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source