Results 41 to 50 of about 186,066 (336)

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses.

PLoS Pathogens, 2015
The innate immune system pattern recognition receptors (PRR) are the first line of host defenses recognizing the various pathogen- or danger-associated molecular patterns and eliciting defenses by regulating the production of pro-inflammatory cytokines ...
Dipanjan Dutta, Sujoy Dutta, Mohanan Valiya Veettil, Arunava Roy, Mairaj Ahmed Ansari, Jawed Iqbal, Leela Chikoti, Binod Kumar, Karen E Johnson, Bala Chandran   +9 more
doaj   +1 more source

Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha. [PDF]

PLoS ONE, 2017
The GW182/TNRC6 family of proteins are central scaffolds that link microRNA-associated Argonaute proteins to the cytoplasmic decay machinery for targeted mRNA degradation processes.
Jessica J Chaston, Alastair Gordon Stewart, Mary Christie   +2 more
doaj   +1 more source

The organization of the microtubule cytoskeleton and its role on nuclear dynamics in the multinucleate hyphae of "Ashbya gossypii" revealed by live cell imaging and electron microscopy [PDF]

, 2009
Nuclear migration is important for normal growth and development of all eukaryotes including filamentous fungi. Among those, Ashbya gossypii, which is evolutionarily related to the budding yeast Saccharomyces cerevisiae, is a particularly attractive ...
Birrer-Lang, Claudia
core   +1 more source

Evidence for the existence of an oligomeric, non-DNA-binding complex of the progesterone receptor in the cytoplasm

European Journal of Histochemistry, 2009
Steroid receptors are found as a hetero-oligomeric complex in cell extracts. Due to the dynamic interaction between receptor-associated proteins and receptors, it is difficult to study the oligomeric complex in living cells.
S Passinen, T Ylikomi
doaj   +1 more source

Expression of Tas1 taste receptors in mammalian spermatozoa [PDF]

, 2012
Background: During their transit through the female genital tract, sperm have to recognize and discriminate numerous chemical compounds. However, our current knowledge of the molecular identity of appropriate chemosensory receptor proteins in sperm is ...
Ulrich Boehm (180339), de Angelis Martin Hrabé, Breit, A., Dorke Meyer, Andreas Breit (180329), Hrabě de Angelis, M., Widmayer Patricia, Wolfgang Meyerhof, Boekhoff Ingrid, Boehm, Ulrich, Martin Hrabé de Angelis, Meyer, Dorke, Ulrich Boehm, Dorke Meyer (180311), Sandra Huebner, Gudermann, T., Boehm, U., Borth, Heike, Borth Heike, Meyerhof, Wolfgang, Susan Marschall, Huebner Sandra, Voigt, Anja, Meyerhof, W., Hrabé de Angelis, Martin, Huebner, S., Sandra Huebner (180323), Thomas Gudermann (77426), Huebner, Sandra, Heike Borth, Borth, H., Susan Marschall (180334), Meyerhof Wolfgang, Ingrid Boekhoff, Ingrid Boekhoff (180345), Heike Borth (180317), Andreas Breit, Meyer Dorke, Boekhoff, I., Voigt Anja, Thomas Gudermann, Anja Voigt, Voigt, A., Gudermann Thomas, Breit Andreas, Boehm Ulrich, Marschall Susan, Marschall, Susan, Widmayer, Patricia, Widmayer, P., Wolfgang Meyerhof (7851), Patricia Widmayer, Martin Hrabé de Angelis (10007), Patricia Widmayer (180314), Breit, Andreas, Boekhoff, Ingrid, Gudermann, Thomas, Anja Voigt (173059), Marschall, S., Meyer, D., Meyer, D. ; Voigt, A. ; Widmayer, P. ; Borth, H. ; Huebner, S. ; Breit, A. ; Marschall, S. ; Hrabé de Angelis, M. ; Boehm, U. ; Meyerhof, W. ; Gudermann, T. ; Boekhoff, I.   +60 more
core   +1 more source

Cytoplasmic TRAIL-R1 is a positive prognostic marker in PDAC

BMC Cancer, 2018
Background The death receptors TRAIL-R1 and TRAIL-R2 are frequently overexpressed in cancer and there is an emerging evidence for their important role in malignant progression, also in the case of pancreatic ductal adenocarcinoma (PDAC).
Jan-Paul Gundlach, Charlotte Hauser, Franka Maria Schlegel, Christine Böger, Christian Röder, Christoph Röcken, Thomas Becker, Jan-Hendrik Egberts, Holger Kalthoff, Anna Trauzold   +9 more
doaj   +1 more source

NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription

Nature Communications, 2017
Myosin VI (MVI) is known to interact with RNA Polymerase II and to play non-cytoplasmic roles in cells. Here, the authors provide evidence that the transcription co-activator NDP52 regulates MVI binding to DNA and that MVI interacts with nuclear ...
Natalia Fili, Yukti Hari-Gupta, Ália dos Santos, Alexander Cook, Simon Poland, Simon M. Ameer-Beg, Maddy Parsons, Christopher P. Toseland   +7 more
doaj   +1 more source

Nuclear-Cytoplasmic Trafficking of NTF2, the Nuclear Import Receptor for the RanGTPase, Is Subjected to Regulation

PLoS ONE, 2012
NTF2 is a cytosolic protein responsible for nuclear import of Ran, a small Ras-like GTPase involved in a number of critical cellular processes, including cell cycle regulation, chromatin organization during mitosis, reformation of the nuclear envelope following mitosis, and controlling the directionality of nucleocytoplasmic transport.
Shawn C Chafe, Jacqueline B Pierce, Dev Mangroo   +2 more
openaire   +4 more sources

Growth Factors, and Cytokines; Understanding the Role of Tyrosine Phosphatase SHP2 in Gametogenesis and Early Embryo Development

Cells, 2020
Growth factors and cytokines have vital roles in germ cell development, gamete maturation, and early embryo development. Cell surface receptors are present for growth factors and cytokines to integrate with and trigger protein signaling in the germ and ...
Muhammad Idrees, Seon-Hwa Oh, Tahir Muhammad, Marwa El-Sheikh, Seok-Hwan Song, Kyeong-Lim Lee, Il-Keun Kong   +6 more
doaj   +1 more source

Characterization of nuclear localization signals and cytoplasmic retention region in the nuclear receptor CAR

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2005
The constitutive androstane receptor (CAR) is a ligand/activator-dependent transactivation factor that resides in the cytoplasm and forms part of an as yet unidentified protein complex. Upon stimulation, CAR translocates into the nucleus where it modulates the transactivation of target genes.
Kanno, Yuichiro, Suzuki, Motoyoshi, Nakahama, Takayuki, Inouye, Yoshio   +3 more
openaire   +2 more sources