Results 61 to 70 of about 186,066 (336)

Bile acids differentially regulate longitudinal smooth muscle contractility in everted mouse ileum

FASEB BioAdvances
Bile acids regulate gastrointestinal motility by mechanisms that are poorly understood. Standard isolated tissue bath assays might not recapitulate in vivo physiology if contractile responses to certain bile acids require direct application to the ...
Peace N. Dike, Krishnakant G. Soni, Diana S. Chang, Geoffrey A. Preidis   +3 more
doaj   +1 more source

Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis

Frontiers in Neuroscience
Cytoplasmic mislocalisation and nuclear depletion of TDP-43 are pathological hallmarks of amyotrophic lateral sclerosis (ALS), including mutations in the C9ORF72 gene that characterise the most common genetic form of ALS (C9ALS).
Manpreet Singh Atwal, Jerneja Nimac, Jerneja Nimac, Urša Čerček, Urša Čerček, Sarah Ricarda Goesch, Hannah Rebecca Goesch, Paraskevi Tziortzouda, Tiziana Ercolani, Anna Zatorska, Terouz Pasha, Ivo Carre, Jacqueline Mitchell, Claire Troakes, Bart Tummers, Vera Župunski, Boris Rogelj, Boris Rogelj, Tibor Hortobágyi, Tibor Hortobágyi, Frank Hirth   +20 more
doaj   +1 more source

Androgen Receptors Expression in Pituitary of Male Viscacha in relation to Growth and Reproductive Cycle

International Journal of Endocrinology, 2015
The aim of this work was to study the androgen receptors (AR) expression in pituitary pars distalis (PD) of male viscachas in relation to growth and reproductive cycle. AR were detected by immunocytochemistry and quantified by image analysis.
Verónica Palmira Filippa, Gabriela Judith Rosales, Albana Andrea Marina Cruceño, Fabian Heber Mohamed   +3 more
doaj   +1 more source

Therapeutic dissolution of aberrant phases by nuclear-import receptors

Trends in Cell Biology, 2019
Nuclear-import receptors (NIRs) bind nuclear-localization signals (NLSs) of protein cargo in the cytoplasm and transport them into the nucleus. Here, we review advances establishing that NIRs also function in the cytoplasm to prevent and reverse ...
Lin Guo, Charlotte M. Fare, J. Shorter
semanticscholar   +1 more source

ARHI (DIRAS 3), an Imprinted Tumor Suppressor Gene, Binds to Importins, and Blocks Nuclear Translocation of Stat3 [PDF]

, 2008
ARHI (DIRAS3) is an imprinted tumor suppressor gene whose expression is lost in the majority of breast and ovarian cancers. Unlike its homologs Ras and Rap, ARHI functions as a tumor suppressor.
Wenbo Lin, Yiling Lu, In Soon Chang, Robert Bast, Jr., Warren Liao, Shaoyi Huang, Zhen Lu, Tao Tao, Ke Zhang, Robert Luo, Yinhua Yu, Xiaomin Chen   +11 more
core  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Androgen-induced migration in NIH3T3 mouse fibroblasts: role of AR association with Filamin A. [PDF]

, 2010
Androgen stimulation triggers rapid activation of various signaling effectors in target cells (Migliaccio et al. 2000; Castoria et al. 2003). This occurs through a direct interaction of classical steroid receptors with proto-oncogenic tyrosine kinase ...
Giraldi, Tiziana
core   +1 more source

Functional characterisation of phagocytes in the Pacific oyster Crassostrea gigas [PDF]

PeerJ, 2016
Invertebrates lack canonical adaptive immunity and mainly rely on innate immune system to fight against pathogens. The phagocytes, which could engulf and kill microbial pathogens, are likely to be of great importance and have to undertake significant ...
Shuai Jiang, Zhihao Jia, Tao Zhang, Lingling Wang, Limei Qiu, Jinsheng Sun, Linsheng Song   +6 more
doaj   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Nuclear œstrogen receptors and treatment of breast cancer

, 1977
In an attempt to improve the predictive value of œstrogen-receptor measurements in breast-tumour biopsy specimens, œstrogen receptor was measured at both cytoplasmic and nuclear levels.
Calman, K. C., Leake, R. E., Smith, M. G., Laing, Linda, Smith, D. C.   +4 more
core   +1 more source