Results 71 to 80 of about 186,066 (336)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
GABAB receptor, localization and regulation [PDF]
, 2009 GABAB receptors are G-protein coupled receptors for gamma-amino butyric acid, the main inhibitory neurotransmitter in the brain. Functional GABAB receptors are obligate heterodimers composed of GABAB1 and GABAB2 subunits. The GABAB1 subunit exists in two
Guetg, Nicole
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
The role of progesterone in the regulation of ciliary activity in the fallopian tube [PDF]
, 2009 The overall aim of this thesis was to investigate the distribution and regulation of membrane progesterone receptors (mPRs) that may be involved in regulating ciliary activity in the fallopian tube.
Nutu, Magdalena
core +1 more source
PLoS ONE, 2017 PurposeMutations in BRCA1 are associated with familial as well as sporadic aggressive subtypes of breast cancer, but less is known about whether BRCA1 expression or subcellular localization contributes to progression in population-based settings ...
Abeer M Mahmoud +6 more
doaj +1 more source
Structure-function analysis of barley NLR immune receptor MLA10 reveals its cell compartment specific activity in cell death and disease resistance. [PDF]
PLoS Pathogens, 2012 Plant intracellular immune receptors comprise a large number of multi-domain proteins resembling animal NOD-like receptors (NLRs). Plant NLRs typically recognize isolate-specific pathogen-derived effectors, encoded by avirulence (AVR) genes, and trigger ...
Shiwei Bai +11 more
doaj +1 more source
Identification and functional characterization of a mouse lymphotoxin beta-receptor like protein [PDF]
, 2005 Four different monoclonal rat anti mouse lymphotoxin beta-receptor (mLTbetaR) antibodies were generated in order to study the expression patterns and molecular mechanisms that follow the activation of this receptor which belongs to the TNFR superfamily ...
Seegers, Silvia
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Open Biology, 2022 Splicing factor proline- and glutamine-rich (SFPQ) is a nuclear RNA-binding protein that is involved in a wide range of physiological processes including neuronal development and homeostasis.
Jocelyn Widagdo +7 more
doaj +1 more source