Results 1 to 10 of about 389,979 (247)

Sensing microbial RNA in the cytosol [PDF]

Frontiers in Immunology, 2013
The innate immune system faces the difficult task of keeping a fine balance between sensitive detection of microbial presence and avoidance of autoimmunity.
Nicolas eVABRET, Julie Magarian eBlander
doaj   +5 more sources

Mycobacterium tuberculosis subverts the TLR-2-MyD88 pathway to facilitate its translocation into the cytosol. [PDF]

PLoS ONE, 2014
Mycobacterium tuberculosis (M.tb) has evolved mechanisms to evade its destruction in phagolysosomes, where it successfully survives and replicates within phagocytes.
Aejazur Rahman, Parveen Sobia, Neeta Gupta, Luc Van Kaer, Gobardhan Das   +4 more
doaj   +5 more sources

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

Journal of Cell Biology, 1997
Bax, a member of the Bcl-2 protein family, accelerates apoptosis by an unknown mechanism. Bax has been recently reported to be an integral membrane protein associated with organelles or bound to organelles by Bcl-2 or a soluble protein found in the ...
Richard Youle, Xu-Guang Xi, Youle Richard J   +2 more
exaly   +2 more sources

ATP compartmentation in plastids and cytosol of Arabidopsis thaliana revealed by fluorescent protein sensing

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance By studying in vivo changes of ATP levels in the plastids and cytosol of Arabidopsis thaliana using a FRET-based ATP sensor, we show that the plastidic ATP concentrations in cotyledon, hypocotyl, and root of 10-day-old seedlings are ...
Stephan Wagner, Per Gardeström, Philippe Fuchs   +2 more
exaly   +2 more sources

From vesicle to cytosol

eLife, 2018
Drugs called bisphosphonates are used to treat a range of bone diseases, but how do they reach the enzymes that are their target?
Michael J Rogers, Marcia A Munoz
doaj   +4 more sources

Live-cell tracking of biliverdin trafficking reveals metabolic exchange between plastids and peroxisomes [PDF]

Biology Open
Mone Shibata, Keiji Yoshida, Hitomi Takahashi, Yutaka Kodama   +3 more
doaj   +2 more sources

Relationship between Cytosol Tps, Tpa and Cell Proliferation [PDF]

The International Journal of Biological Markers, 1994
The serological tumor marker tissue polypeptide antigen (TPA) and the more recently identified tissue-specific polypeptide antigen (TPS) have been reported to be indicators of the proliferation rate of the tumor.
M. Gion, R. Mione, A. Becciolini, M. Balzi, M. Correale, A. Piffanelli, G. Giovannini, G. Saccani Jotti, M. Fontanesi   +8 more
doaj   +2 more sources

Endoplasmic Reticulum Calcium Regulates the Retrotranslocation of Trypanosoma Cruzi Calreticulin to the Cytosol [PDF]

PLoS ONE, 2010
For most secretory pathway proteins, crossing the endoplasmic reticulum (ER) membrane is an irreversible process. However, in some cases this flow can be reversed.
Ianina Conte, Julio J Caramelo, Armando J Parodi   +2 more
exaly   +2 more sources

Proteomic Shifts Reflecting Oxidative Stress and Reduced Capacity for Protein Synthesis, and Alterations to Mitochondrial Membranes in Neurospora crassa Lacking VDAC

Microorganisms, 2022
Voltage-dependent anion-selective channels (VDAC) maintain the bidirectional flow of small metabolites across the mitochondrial outer membrane and participate in the regulation of multiple cellular processes.
Sabbir R. Shuvo, Anna Motnenko, Oleg V. Krokhin, Victor Spicer, Deborah A. Court   +4 more
doaj   +1 more source

Sub-Cellular Metabolomics Contributes Mitochondria-Specific Metabolic Insights to a Mouse Model of Leigh Syndrome

Metabolites, 2021
Direct injury of mitochondrial respiratory chain (RC) complex I by Ndufs4 subunit mutations results in complex I deficiency (CID) and a progressive encephalomyopathy, known as Leigh syndrome.
Gunter van der Walt, Jeremie Z. Lindeque, Shayne Mason, Roan Louw   +3 more
doaj   +1 more source